Comparison of <scp>CT</scp>‐based volumetric dosimetry with traditional prescription points in the treatment of cervical cancer with <scp>PDR</scp> brachytherapy

Lowrey, Nicola; Nilsson, Sanna; Moutrie, Zoë; Chan, Philip; Cheuk, Robyn

doi:10.1111/1754-9485.12341

Cited by 1 publication

(2 citation statements)

References 22 publications

(36 reference statements)

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“…Therefore, even though IMRT provides a more homogenous dose distribution, this aspect could not be an advantage for tumour control, taking into account that a physical dose delivered by ICBRT could not yield the same biological effects. Moreover, when applying IMRT in place of ICBRT, the crucial key should be the prescription of the dose to the high-risk CTV (CTV-HR) [43,44] as heterogeneous as possible, in order to copycat brachytherapy dosimetry. This could allow delivering more than 80-85Gy EQD2 to CTV-HR [43,44].…”

Section: Discussionmentioning

confidence: 99%

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IMRT and brachytherapy comparison in gynaecological cancer treatment: thinking over dosimetry and radiobiology

Pinzi

Landoni

Cattani

et al. 2019

ecancer

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Background: The role of radiotherapy and brachytherapy in the management of locally advanced cervical and endometrial cancer is well established. However, in some cases, intracavitary brachytherapy (ICBRT) is not recommended or cannot be carried out. We aimed to investigate whether external-beam irradiation delivered by means of intensitymodulated radiation therapy (IMRT) might replace ICBRT in gynaecological cancer when the standard ICBRT boost delivering cannot be administered for technical or clinical reasons. Materials and methods: Fifteen already delivered treatments for gynaecological cancer patients were analysed. The treatments were performed through 3-dimensional conformal radiotherapy (3D-CRT) to the whole-pelvis up to the dose of 45-50.4 Gy followed by a boost dose administered with ICBRT in high-dose-rate or pulsed-dose-rate modality. For each patient, IMRT plans were elaborated to mimic the ICBRT. We analysed the ICBRT boost versus IMRT boost in terms of dosimetric and radiobiological aspects. Results: Mean conformity index value calculated on boost volume was 0.73 for ICBRT and 0.97 for IMRT. Mean conformation number was 0.24 for ICBRT boost and 0.78 for IMRT boost. Mean normal tissue complication probability (NTCP) values for 3D-CRT plus ICBRT and for IMRT (pelvis plus boost) were, respectively, 28% and 5% for rectum; 1.5% and 0.1% for urinary bladder and 8.9% and 6.1% for bowel. Conclusions: Our findings suggest that IMRT may represent a viable alternative in delivering the boost in patients diagnosed with gynaecological cancer not amenable to ICBRT.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, when applying IMRT in place of ICBRT, the crucial key should be the prescription of the dose to the high-risk CTV (CTV-HR) [43,44] as heterogeneous as possible, in order to copycat brachytherapy dosimetry. This could allow delivering more than 80-85Gy EQD2 to CTV-HR [43,44].…”

Section: Discussionmentioning

confidence: 99%

IMRT and brachytherapy comparison in gynaecological cancer treatment: thinking over dosimetry and radiobiology

Pinzi

Landoni

Cattani

et al. 2019

ecancer

View full text Add to dashboard Cite

show abstract

Comparison of CT‐based volumetric dosimetry with traditional prescription points in the treatment of cervical cancer with PDR brachytherapy

Abstract: This study confirms that the regionally relevant practice of CT-based 3D-optimised planning results in improved tumour dose coverage compared with traditional points-based planning methods and also improves dose to the rectum and bladder.

Cited by 1 publication

References 22 publications

IMRT and brachytherapy comparison in gynaecological cancer treatment: thinking over dosimetry and radiobiology

IMRT and brachytherapy comparison in gynaecological cancer treatment: thinking over dosimetry and radiobiology

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