Comparison of scoring tools for the prediction of in-hospital mortality in status epilepticus

Reindl, Caroline; Knappe, Ruben U.; Sprügel, Maximilian I.; Sembill, Jochen A.; Mueller, Tamara M.; Hamer, Hajo M.; Huttner, Hagen B.; Madžar, Dominik

doi:10.1016/j.seizure.2018.01.024

Cited by 24 publications

(34 citation statements)

References 23 publications

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“…The AUC of STESS and EMSE were relatively low in our study, ranged between 0.6–0.7. Most previous studies from different geographic regions reported similar figures, ranged from 0.5–0.7 [7,13,14], except two studies reported AUC ranged between 0.7–0.89 for both tests [21,22]. The reason for lower AUC may be due to the samples size and different ethnicity studied in this cohort.…”

Section: Discussionmentioning

confidence: 55%

“…Recently, a study investigated the accuracy of STESS, modified STESS, EMSE-EAL (EMSE including only etiology, age, and level of consciousness), and END-IT in outcome-prediction for in-hospital mortality. The results indicated a low specificity for STESS, balanced sensitivity-specificity ratio for END-IT, and high specificity for EMSE [7]. However, EEG data (used for EMSE outcome-predication) of the patients were excluded, and ENT-IT was not performed in every patient due to unavailable of brain image.…”

Section: Introductionmentioning

confidence: 99%

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Predicting the Functional Outcome of Adult Patients with Status Epilepticus

Lin

et al. 2019

JCM

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Patients that survive status epilepticus (SE) may suffer from neurological and cognitive deficits that cause severe disabilities. An effective scoring system for functional outcome prediction may help the clinician in making treatment decisions for SE patients. Three scoring systems, namely the Status Epilepticus Severity Score (STESS), the Epidemiology-Based Mortality Score in Status Epilepticus (EMSE), and the Encephalitis-Nonconvulsive Status Epilepticus-Diazepam Resistance-Image Abnormalities-Tracheal Intubation (END-IT), have been developed in the past decade to predict the outcomes of patients with SE. Our study aimed at evaluating the effectiveness of these scores in predicting the function outcomes both at and after discharge in SE patients. We retrospectively reviewed the clinical data of 55 patients admitted to our neurological intensive care unit between January 2017 and December 2017. The clinical outcomes at discharge and at last follow-up were graded using the modified Rankin Scale. Our research indicated that STESS was the most sensitive and EMSE was the most specific predictive scoring method for SE outcome prediction. On the other hand, END-IT predicted functional outcomes in SE patients poorly. We concluded that STESS and EMSE can accurately predict the functional outcomes in SE patients both at discharge and the follow-up period.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Predicting the Functional Outcome of Adult Patients with Status Epilepticus

Lin

et al. 2019

JCM

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“…Patients' characteristics A total of 129 adult patients with incident, first-time status epilepticus were analyzed in this study. 19.4% of the patients had an acute symptomatic cause or suffered from progressive brain disease (1 patient with Lewy body disease, all others suffered from malignant brain tumors) as defined in [31]. EEG showed SE with or without predominant motor symptoms in 78% of all patients.…”

Section: Resultsmentioning

confidence: 99%

“…In the original publication, STESS with a cut-off of ≥3 achieved the highest accuracy [5]. However, later studies suggested that a cut-off of ≥4 has a more favorable sensitivity and specificity [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology-Based Mortality Score is Associated with Long-Term Mortality after Status Epilepticus

et al. 2019

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The authors' contributions are given below. All meet the requirement for authorship. The manuscript has not been submitted elsewhere or is under consideration by another journal. Financial support: This study was supported by a grant of the Region of Southern Denmark to CPB (17/18517). This study adheres to the relevant ethical guidelines and was evaluated and approved by the local authorities as described in the Methods section of the manuscript.

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The value of serum albumin concentration in predicting functional outcome of status epilepticus: An observational study

Liao

Zeng

et al. 2023

Epileptic Disorders

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Objective: Status epilepticus (SE) is a common neurological emergency with unsatisfying prognoses, and accurate prediction of functional outcome is beneficial in clinical decision-making. The relationship between serum albumin concentration and outcome of SE patients has yet to be unveiled. Methods: Clinical profiles of SE patients admitted to Xiangya Hospital, CentralSouth University, from April 2017 to November 2020, were analyzed retrospectively. Outcomes of SE patients at discharge were divided into two groups based on the modified Rankin Scale (mRS): favorable outcome (mRS: 0-3) and unfavorable outcome (mRS: 4-6).Results: Fifty-one patients were enrolled. Unfavorable functional outcome at discharge was reported in 60.8% (31/51). Serum albumin concentration at admission and the Encephalitis-NCSE-Diazepam resistance-Image abnormalities-Tracheal intubation (END-IT) score remained independent predictors for functional outcome of SE patients. A lower albumin concentration at admission and higher END-IT score indicated a higher chance of unfavorable outcome for SE patients.The cut-off value of serum albumin to predict unfavorable outcome was 35.2 g/L, with a sensitivity of 67.7% and specificity of 85.0%, and an area under the receiver operating characteristic curve (ROC) of .738 (95% CI: .600-.876, p = .004). The preferable END-IT score with optimal sensitivity (74.2%) and specificity (60%) was 2 and the area under the ROC was .742, with 95% CI of .608-.876 (p = .004).Significance: Serum albumin concentration at admission and the END-IT score are two independent predictive factors for short-term outcome of SE patients, moreover, the serum albumin concentration is not inferior to the END-IT score in indicating functional outcome at discharge.

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Comparison of scoring tools for the prediction of in-hospital mortality in status epilepticus

Cited by 24 publications

References 23 publications

Predicting the Functional Outcome of Adult Patients with Status Epilepticus

Predicting the Functional Outcome of Adult Patients with Status Epilepticus

Epidemiology-Based Mortality Score is Associated with Long-Term Mortality after Status Epilepticus

The value of serum albumin concentration in predicting functional outcome of status epilepticus: An observational study

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