Comparison of salivary total protein and electrolyte profile in HIV patients with and without antiretroviral therapy

Mahajan, Pratiksha; Kheur, Supriya; Mahajan, Gundappa D.; Kheur, Mohit; Raj, A. Thirumal; Patil, Shankargouda; Awan, Kamran Habib

doi:10.1016/j.disamonth.2021.101165

Cited by 2 publications

(4 citation statements)

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“…Prevalence of DC and associated risk factors are the main focus of most publications [ 17 – 20 ]. Few studies have addressed salivary parameters in PLWHA [ 12 , 16 , 23 , 24 , 29 ] and only one study has been reported about sIgA and DC in PLWHA [ 30 ]. To the best of our knowledge, this study is the first to investigate 18 biochemical salivary parameters and SFR in adult PLWHA, as well as and DC in PLWHA receiving ART.…”

Section: Discussionmentioning

confidence: 99%

“…Biocina LD et al, observed an increase in calcium levels with highly active ART [ 23 ]. However, for Mahajan PG et al the increase of calcium levels were due to the virus and the alteration of Na, K and Cl could be due to the combined effect of ART and HIV [ 12 ]. In addition, Shahar E et al showed that electrolytes, including Ca, reverted to normal in people on highly active ART [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the impairment of saliva composition by HIV infection, ART regimen and poor oral hygiene may predispose the patient to oral diseases. Affections like candidiasis, dental caries (DC), periodontal diseases, hyperpigmentation and salivary glands dysfunction are still common [ 12 – 16 ]. A part from cariogenic bacteria such as S. mutans and lactobacilli, several contributing factors are reported to be involved in DC like age, ART duration, carbohydrate-rich diet, tobacco and drugs use [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Salivary biochemical parameters in people living with HIV on ART and dental caries: a cross-sectional study in Monastir, Tunisia

Berrezouga,

Kooli,

Marrakchi

et al. 2024

BMC Oral Health

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Background Studies regarding salivary biochemical parameters and dental caries in adult people living with HIV/AIDS (PLWHA) are scanty. Aim: To investigate salivary biochemical parameters and dental caries in adult PLWHA who are on antiretroviral therapy (ART) and compare the findings with people negative for HIV infection. Methods The study included 50 HIV positive individuals as a test group (TG) and 50 HIV negative individuals as a control group (CG). Dental examination was performed according to WHO guidelines to assess DMFT. Digital panoramic radiographs were taken to detect additional infectious foci. Non-stimulated saliva was collected between 9 and 12 a. m for 5 min to evaluate 18 biochemical parameters and salivary flow rate (SFR). Parametric and non parametric tests were used according to data distribution. The level of significance was set at p < 0.05%. Results Patients’ mean ages and M/F sex ratios for TG and CG were 38.80 ± 9.69 y/o. vs. 37.98 ± 13.47 y/o. and 3.54 vs. 2.33, respectively. Higher means of decayed teeth were recorded in TG, 4.47 ± 3.00 vs. 3.88 ± 2.81 in CG with no significant difference (p = 0.41). Means of filled teeth were significantly lower in TG 2.38 ± 2.16 vs. 4.16 ± 3.35 in CG (p = 0.01), respectively. No statistical significant difference was noted in DMFT indices between the 2 groups (8.04 ± 6.90 vs. 8.52 ± 6.24, p = 0.71). The following salivary parameters were significantly lower in TG compared to CG, respectively: mean SFR 0.44 ± 0.18 ml/min vs. 0.61 ± 0.26 ml/min; median levels of sodium and chlorides, 4 mmol/L and 13.5 mmol/L vs. 9 mmol/L and 19 mmol/L (p < 0.001) and uric acid, 103.50 mmol/L vs. 163 (p = 0.009). However, higher median levels were recorded with calcium, 1.09 mmol/L vs. 0.54 (p < 0.001) and sIgA 23 mg/dl vs. 5 mg/dl (p < 0.001). In TG, a positive correlation was found between DC, potassium, urea, and chlorides (p < 0.05). Salivary renal and hepatic biomarkers were comparable between the two groups. Conclusions PLWHA have shown an alteration in some salivary parameters, more decayed teeth and less filled teeth. Preventive measures should be implemented to lower dental caries and enhance accessibility to oral care services. In addition, saliva can be utilized to monitor oral and general health status among PLWHA on ART.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salivary biochemical parameters in people living with HIV on ART and dental caries: a cross-sectional study in Monastir, Tunisia

Berrezouga,

Kooli,

Marrakchi

et al. 2024

BMC Oral Health

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“…Over the past decade, exploration of body fluid proteins has been considered as one of the plausible approaches to find candidate biomarkers for various diseases in the humans 15 – 18 . Thus, salivary proteins have been recommended as biomarkers to predict disease conditions such as Sjogren’s syndrome 19 , lung cancer 20 , oral cancer 21 , several systemic diseases 22 , HIV infection 23 , 24 , dental pellicle development 25 , hyperglycemia 26 , etc. Recently, it has been reported that salivary hormones and proteins have the potential to predict ovulation in women 27 , 28 .…”

Section: Introductionmentioning

confidence: 99%

Ectopic pregnancy: search for biomarker in salivary proteome

Priya Aarthy,

Sen,

Srinivasan

et al. 2023

Sci Rep

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Ectopic pregnancy (EP) is associated with high maternal morbidity and mortality. Ultrasonography is the only dependable diagnostic tool for confirming an ectopic pregnancy. In view of inadequate early detection methods, women suffer from a high-life risk due to the severity of EP. Early detection of EP using pathological/molecular markers will possibly improve clinical diagnosis and patient management. Salivary proteins contain potential biomarkers for diagnosing and detecting various physiological and/or pathological conditions. Therefore, the present investigation was designed to explore the salivary proteome with special reference to EP. Gel-based protein separation was performed on saliva, followed by identification of proteins using Liquid Chromatography-Tandem Mass Spectrometry (LC–MS/MS). Totally, 326 proteins were identified in the salivary samples, among which 101 were found to be specific for ruptured ectopic pregnancy (EPR). Reactome analysis revealed innate immune system, neutrophil degranulation, cell surface interactions at the vascular wall, and FCERI-mediated NF-kB activation as the major pathways to which the salivary proteins identified during EPR are associated. Glutathione-S-transferase omega-1 (GSTO1) is specific for EPR and has been reported as a candidate biomarker in the serum of EPR patients. Therefore, saliva would be a potential source of diagnostic non-invasive protein biomarker(s) for EP. Intensive investigation on the salivary proteins specific to EP can potentially lead to setting up of a panel of candidate biomarkers and developing a non-invasive protein-based diagnostic kit.

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Comparison of salivary total protein and electrolyte profile in HIV patients with and without antiretroviral therapy

Cited by 2 publications

References 15 publications

Salivary biochemical parameters in people living with HIV on ART and dental caries: a cross-sectional study in Monastir, Tunisia

Salivary biochemical parameters in people living with HIV on ART and dental caries: a cross-sectional study in Monastir, Tunisia

Ectopic pregnancy: search for biomarker in salivary proteome

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