Comparison of safety and efficacy of silodosin, solifenacin, tadalafil and their combinations in the treatment of double-J stent- related lower urinary system symptoms: A prospective randomized trial

Abstract

Combination therapy with silodosin and solifenacin (group E) was effective for relieving SRS with improved quality of life and less requirement of analgesic than any other groups and should be considered in patients who develop SRS.

Management of stent-related symptoms with the use of α-blockers: A meta-analysis

“…We further excluded 41 articles due to lack of the use of the USSQ or USSQ completion at several time points, no use of placebo or considerable lack of data. Overall, eight papers, published between 2006 and 2018 were eligible for the meta-analysis, including 1350 patients receiving tamsulosin 0.4 mg, alfuzosin 10 mg or placebo and were compared with silodosin 8 mg, solifenacin 5 mg, tadalafil 5 mg, or combinations [8][9][10][11][12][13][14][15]. The aforementioned stages are illustrated in detail in Figure 1 and all studies are listed in Table 1 [8][9][10][11][12][13][14][15].…”

“…The duration of treatment with α-blockers varied between 1 and 8 weeks. Multi-length JJ stents composed of polyurethane [8,[11][12][13][14], silicone [15] and proprietary co-polymer [9,10] were used.…”

“…The α-blocker used was: alfuzosin 10 mg compared to placebo [8,14]; tamsulosin compared to placebo [12,15]; tamsulosin compared to alfuzosin 10 mg and placebo [9]; tamsulosin compared to tadalafil 5 mg [11]; tamsulosin compared to solifenacin 5 mg and their combination, and placebo [10]; and silodosin 8 mg compared to several combinations of drugs including solifenacin 10 mg, tadalafil 5 mg, and placebo [13]. All studies were placebo controlled and used a JJ stent.…”

“…No patients were reported to have discontinued α-blockers due to side-effects. α-blockers side-effects were not formally evaluated in three studies [9,10,13], one study reported α-blockers side-effects as minimal without precisely naming them [11], while four studies reported side-effects [8,12,14,15]. Deliveliotis et al [8] reported dizziness and headache as the most frequent side-effects reaching 8% each, Singh et al [12] reported postural hypotension as their most frequent side-effect (13.33%), Nazim and Ather [14] reported orthostatic dizziness (7.7%), whilst Wang et al [15] reported transient hypotension, asthenia, syncope and palpitations (3.8%) as their most frequent side-effects, respectively.…”

Role of phosphodiesterase inhibitors in stent-related symptoms: a systematic review and meta-analysis

“…Only three studies fulfilled the methodological requirements, i.e., the population base of 280 patients is quite limited. The three randomized control trials collected for analysis in this study are with significant heterogeneity in study design, especially in comparison with different drugs (Aggarwal et al [2]: tadalafil 5 mg vs placebo vs tamsulosin 0.4 mg; Bhattar et al [3]: tadalafil 5 mg vs placebo vs silodosin 8 mg; Tharwat et al [4]: sildenafil 50 mg vs placebo), which made the data less comparable. 2.…”