Comparison of Safety and Effectiveness of Two Different Transfusion Rates in Children With Severe Anemia

Olgun, Haşim; Büyükavcı, Mustafa; Sepetcigil, Oguzhan; Yıldırım, Zühal; Karacan, Mehmet; Ceviz, Naci

doi:10.1097/mph.0b013e3181b27073

Cited by 7 publications

(5 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rate of transfusion in this study is higher than that of Jayabose et al Tolerance to higher rates of blood transfusion has been demonstrated in an earlier study. [27] The reduction in the parameters except O 2 sat and blood pressure in response to blood transfusion in this study is consistent with previous reports in adult and children. [11,12,28,29] The HR and RR had the most easily measurable reduction compared with change in liver size.…”

Section: Discussionsupporting

confidence: 93%

Cardiovascular responses to blood transfusion in children with anemic heart failure

Sadoh

Okposio

2012

Niger J Clin Pract

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Cardiovascular responses to blood transfusion in children with anemic heart failure

Sadoh

Okposio

2012

Niger J Clin Pract

View full text Add to dashboard Cite

show abstract

“…5 6 7 8 9 10 11 12 13 15 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 72 73 Three identified records provided data from the same trial 4546 47 We excluded a total of 26 records,46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 the primary reasons being a lack of well defined haemoglobin or haematocrit levels guiding the intervention (six records),48 49 50 51 52 53 the inclusion of preterm or very low birth weight neonates (seven records),54 55 56 57 58 59 60 71 and secondary publications or subgroup analyses (nine records) 4647 60 61 62 63 64 65 66 Three records related to ongoing trials 67…”

Section: Resultsmentioning

confidence: 99%

Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis

Holst

Petersen

Haase

et al. 2015

BMJ

379

261

View full text Add to dashboard Cite

ObjeCtive To compare the benefit and harm of restrictive versus liberal transfusion strategies to guide red blood cell transfusions. DesignSystematic review with meta-analyses and trial sequential analyses of randomised clinical trials. Data sOurCesCochrane central register of controlled trials, SilverPlatter Medline (1950 to date), SilverPlatter Embase (1980 to date), and Science Citation Index Expanded (1900 to present). Reference lists of identified trials and other systematic reviews were assessed, and authors and experts in transfusion were contacted to identify additional trials.trial seleCtiOn Published and unpublished randomised clinical trials that evaluated a restrictive compared with a liberal transfusion strategy in adults or children, irrespective of language, blinding procedure, publication status, or sample size. Data extraCtiOnTwo authors independently screened titles and abstracts of trials identified, and relevant trials were evaluated in full text for eligibility. Two reviewers then independently extracted data on methods, interventions, outcomes, and risk of bias from included trials. random effects models were used to estimate risk ratios and mean differences with 95% confidence intervals. results 31 trials totalling 9813 randomised patients were included. The proportion of patients receiving red blood cells (relative risk 0.54, 95% confidence interval 0.47 to 0.63, 8923 patients, 24 trials) and the number of red blood cell units transfused (mean difference −1.43, 95% confidence interval −2.01 to −0.86) were lower with the restrictive compared with liberal transfusion strategies. Restrictive compared with liberal transfusion strategies were not associated with risk of death (0.86, 0.74 to 1.01, 5707 patients, nine lower risk of bias trials), overall morbidity (0.98, 0.85 to 1.12, 4517 patients, six lower risk of bias trials), or fatal or non-fatal myocardial infarction (1.28, 0.66 to 2.49, 4730 patients, seven lower risk of bias trials). Results were not affected by the inclusion of trials with unclear or high risk of bias. Using trial sequential analyses on mortality and myocardial infarction, the required information size was not reached, but a 15% relative risk reduction or increase in overall morbidity with restrictive transfusion strategies could be excluded. COnClusiOnsCompared with liberal strategies, restrictive transfusion strategies were associated with a reduction in the number of red blood cell units transfused and number of patients being transfused, but mortality, overall morbidity, and myocardial infarction seemed to be unaltered. Restrictive transfusion strategies are safe in most clinical settings. Liberal transfusion strategies have not been shown to convey any benefit to patients. trial registratiOn PROSPERO CRD42013004272.

show abstract

“…Increases in ABP occur following transfusion of NLR-pRBCs in adult humans (Shoemaker and Wo, 1998; Saugel et al, 2013) and after transfusion of LR-pRBCs in premature and low birth-weight infants (Rankova and Beshinska, 1989; Bauer et al, 1993; Alkalay et al, 2003) and neonates (Rashid et al, 2013) but not always in children with severe anemia (Grant et al, 2003; Olgun et al, 2009). Transfusions of LR-pRBCs do not always impact ABP because of lower pRBC volumes and transfusion rates (Nelle et al, 1994, 1997) and because increases in total peripheral resistance are matched by decreases in cardiac output (CO) (Nelle et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Effects of non-leukocyte-reduced and leukocyte-reduced packed red blood cell transfusions on oxygenation of rat spinotrapezius muscle

Sundararajan

Dodhy

Pittman

et al. 2014

Microvascular Research

View full text Add to dashboard Cite

Leukoreduction of blood used for transfusion alleviates febrile transfusion reactions, graft versus host disease and alloimmunization to leukocyte antigen. However, the actual clinical benefit of leukoreduction in terms of microcirculatory tissue O2 delivery after packed red blood cell (pRBC) transfusion has not been investigated. As such, the aim of this study was to determine the effects of non-leukoreduced (NLR) and leukoreduced (LR) fresh pRBC transfusion on interstitial oxygenation in anesthetized male Sprague-Dawley rats. Interstitial fluid PO2 and arteriolar diameters in spinotrapezius muscle preparations were monitored before and after transfusion with NLR- or LR-pRBCs. The major findings were that (1) transfusion of NLR-pRBCs significantly decreased interstitial oxygenation whereas transfusion of LR-pRBCs did not, and (2) transfusion with LR-pRBCs elicited a substantially greater increase in arterial blood pressure (ABP) than did transfusion with NLR-pRBCs. These changes in PO2 and ABP were not associated with changes in the diameters of resistance arterioles in the spinotrapezius muscle. These data suggest that transfusion of fresh NLR-pRBCs may negatively affect tissue oxygenation via enhanced leukocyte influx and decreased O2 delivery. They also suggest that leukocytes diminish the capability of transfused pRBCs to increase cardiac output. As such, transfusion of LR-pRBCs may be less deleterious on tissue PO2 levels than NLR-pRBCs although a concomitantly greater increase in ABP may accompany transfusion of LR-pRBCs.

show abstract

Comparison of Safety and Effectiveness of Two Different Transfusion Rates in Children With Severe Anemia

Cited by 7 publications

References 3 publications

Cardiovascular responses to blood transfusion in children with anemic heart failure

Cardiovascular responses to blood transfusion in children with anemic heart failure

Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis

Effects of non-leukocyte-reduced and leukocyte-reduced packed red blood cell transfusions on oxygenation of rat spinotrapezius muscle

Contact Info

Product

Resources

About