Comparison of rosuvastatin versus atorvastatin in patients with heterozygous familial hypercholesterolemia

Clinical Efficacy and Safety of Rosuvastatin in Japanese Patients With Heterozygous Familial Hypercholesterolemia

“…Some insight into the clinical implications of the results for rosuvastatin from the current trial can also be gained from clinical studies in similar patient populations from different geographic regions. Most notable is a recent randomized, double-blind, dose-titration study in Western patients by Stein et al that featured a similar design (i.e., dose titration every 6 weeks) and the same lipid entry criteria as the current study (11). A total of 623 patients with heterozygous FH were randomized to receive either rosuvastatin or atorvastatin at 20/40/80 mg daily.…”

Recommendations for the management of patients with homozygous familial hypercholesterolaemia: Overview of a new European Atherosclerosis Society consensus statement

“…[11] The effect of high dose statin therapy on LDL-C levels in patients with HoFH is less than one-half that seen in patients with heterozygous disease [10,12]. As shown in Table 4, in heterozygotes high doses of the most potent statins resulted in a mean reduction in LDL-C levels of around 50%, while patients with HoFH the reduction achieved was slightly less than 20% (18 and 19% with atorvastatin and rosuvastatin, respectively).…”

“…Percentage change in low-density lipoprotein cholesterol levels with high doses of rosuvastatin and atorvastatin in patients with heterozygous familial hypercholesterolaemia[12] and homozygous familial hypercholesterolaemia[10].…”

Early onset of coronary heart disease in a young woman with familial hypercholesterolemia: coronary findings and effect of short term treatment with high dose atorvastatin

“…C-reactive protein influences shear stress-dependent platelet adhesion in patients with FH [12]. Therapy with statins is usually recommended [13], both high dose atorvastatin and rosuvastatin [14]. For more severe cases, LDL apheresis is often required [15], since it was shown to be able to stop the progression of coronary atherosclerosis [16].…”