Comparison of Ropivacaine 0.75 % and Lignocaine 2 % with 1:200,000 Adrenaline in Dental Extractions: Single Blind Clinical Trial

Abstract

SDC/MISC/2013/239.

Clinical efficacy of 0.75% ropivacaine vs. 2% lignocaine hydrochloride with adrenaline (1:80,000) in patients undergoing removal of bilateral maxillary third molars: a randomized controlled trial

“…In our study, none of the participants from either group experienced any pain throughout the procedure, but they withstood the procedure well with comfort, indicating adequate pain control. These findings are similar to those of other studies, such as Budharapu et al [ 1 ], Bansal et al [ 14 ], Brković et al [ 20 ], and Reddy et al [ 4 ].…”

“…The onset of anesthesia for lignocaine and ropivacaine varied from 1 to 2 min and 2 to 3 min, respectively, indicating that 2% lignocaine hydrochloride had the quickest onset of anesthesia. In a similar study by Reddy KV et al [ 4 ] and Bansal V et al [ 14 ], lignocaine was faster to act compared to ropivacaine. In our study, the mean onset of anesthesia was statistically insignificant for the ropivacaine group compared with the lignocaine with adrenaline group.…”

“…After its commercial release, ropivacaine has been extensively used for perioperative pain relief in the medical field, with consistently better outcomes than other local anesthetic agents [ 4 ]. Its use in the dental discipline has expanded to studies on periodontic procedures to evaluate its anesthetic efficacy [ 11 ], topical anesthesia of the oral mucosa [ 12 ], simple extraction procedures [ 3 13 14 ], lower third molar surgeries[ 1 4 5 15 16 17 18 19 ], surgical removal of the upper third molars[ 20 ], surgical removal of chronic periapical lesions [ 21 ], oral aphthosis [ 22 ], mandibular osteotomy [ 23 ], and postoperative pain control after elective cleft palate repair in children [ 24 ].…”

Comparison of clinical efficacy of ropivacaine and lignocaine with adrenaline for implant surgery anesthesia: a split-mouth randomized controlled clinical trial

“…In a randomized single-blind study, Bansal and Kumar in terms of quality of anesthesia had reported that ropivacaine 0.75% had a longer duration of action and effective diffusion property than that of lignocaine 2% with adrenaline 1:200000. Additionally, in our study, a comparison of VAS scores at different time points between the two groups demonstrated that the scores in the ropivacaine group were consistently lower than those in the lignocaine group [ 13 ]. Furthermore, the difference in the scores was statistically significant at all time points.…”

Confounding Factors on the Comparison of Diclofenac Versus Ketoprofen as a Transdermal Drug Delivery System

“…The authors conducted a randomized clinical trial involving 50 patients undergoing maxillofacial surgery and concluded that ketoprofen transdermal patch was slightly better than diclofenac transdermal patch with respect to analgesic efficacy. The authors should be applauded for performing a well-designed study in an important topic (e.g., acute pain) in patients undergoing elective surgery [2,3]. The need to improve postoperative recovery by reducing moderate/severe postoperative pain makes the topic very important in maxillofacial surgery [4,5].…”