Comparison of ropivacaine 0.5% (in glucose 5%) with bupivacaine 0.5% (in glucose 8%) for spinal anaesthesia for elective surgery †

Abstract

Ropivacaine 15 mg in glucose 50 mg ml(-1) provides reliable spinal anaesthesia of shorter duration and with less hypotension than bupivacaine. The recovery profile for ropivacaine may be of interest given that more surgery is being performed in the day-case setting.

A double blind prospective study of effect of intrathecal ropivacaine 0.75% and bupivacaine 0.5% for lower limb orthopedic surgery in young patients

“…Difference in the onset of motor blockade in both groups was also found to be statistically significant (P <0.05). These findings of present study are similar with the findings stated by Van [17][18][19][20][21][22] The duration of sensory blockade was defined as time elapsed between injection of study drug and return of the pin prick sensation whereas duration of motor blockade was defined as time between drug injections to complete return of motor power with movement of all lower limb joints. It was found that longer duration of sensory and motor blockade in bupivacaine group as against in ropivacaine group and difference was statistically significant (P <0.05).…”

“…However, in other studies no significant defference was foud in haemodynamics in both ropivacaine and bupivacaine groups when given intrathecally. [18][19][20][23][24][25] In present study no rescue analgesia was required in any of the patients in any group and quality of anesthesia obtained was adequate with both the groups. No signs of central nervous system toxicity (like restlessness, anxiety, incoherent speech, lightheadedness, dizziness, blurred vision, tremors, drowsiness, convulsions) or cardiovascular system toxicity (hypotension, bradycardia, hypertension, tachycardia, vasovagal reaction, arrhythmias like extra-systoles, atrial fibrillation, ST segment changes and myocardial infarction); severe allergic reactions (rash, itching, difficulty in breathing, tightness in the chest, swelling of the mouth, face, lips or tongue); nausea; vomiting noted in both groups.…”

“…The findings correlate with the different studies. [17][18][19][21][22][23][24][25][26] The average highest level of sensory blockade which was achieved by giving either 3.5 ml of 0.75% isobaric ropivacaine or 3.5 ml of 0.5% hyperbaric bupivacaine was compared. The average highest level of sensory blockade in both the groups was T6 which was comparable (P=0.879).…”

“…Similar results were observed by various authors in their studies. 17,[19][20][21]23,26 No significant change in heart rate in ropivacaine group was found but there was significant fall in heart rate after 60 minutes of the induction in bupivacaine group by paired 't' test. The maximum fall in heart rate was 7% at 120 minutes in bupivacaine group while it was 3% at 60 minutes in ropivacaine group.…”

Comparative study of ropivacaine (0.5%) plain versus levobupivacaine (0.5%) plain in gynecological surgeries

“…18 Whiteside et al who found the time to maximum degree of motor block in bupivacaine was significantly less (P<0.001) than ropivacaine group whereas Chung et al found that the both drugs ropivacaine and bupivacaine took similar time to complete motor block. 17,19 In present study in Group R motor block onset time is significantly higher (P=0.030) than Group L. In our study duration of sensory block and motor block is significantly more in Group L than Group R (P=0.037). Breebart et al compared 10 mg levobupivacaine and 15 mg ropivacaine for out patients knee arthroscopy and found the same results, where ropivacaine group moved early and need for postoperative analgesia was less in levobupivacaine but they discharged home late.…”