Comparison of Risk Factors for Hypertrophic Osteodystrophy, Craniomandibular Osteopathy and Canine Distemper Virus Infection

Munjar, T. A.; Austin, Connie C.; Breur, Gert J.

doi:10.1055/s-0038-1632606

Cited by 31 publications

(40 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 Although most breeds are represented sporadically with regard to HOD in the veterinary medical literature, the Great Dane appears to be the most frequently affected breed. The disease has affected entire litters of Weimaraner puppies.…”

Section: Commentsmentioning

confidence: 99%

“…4 Hypertrophic osteodystrophy generally affects the radii, ulnas, and tibias; however, lesions may develop in rapidly growing long bones throughout the appendicular skeleton and occasionally in the axial skeleton (including the maxilla, mandible, costochondral junctions of the ribs, scapulas, and ilia). 1,[4][5][6] The acute onset of bilateral and symmetric lameness is associated with progressive metaphyseal enlargement, which correlates with periosteal proliferation, fibrosis, and ossification. 3 Other clinical signs include anorexia, weight loss, fever, and signs of depression and severe metaphyseal pain.…”

Section: Commentsmentioning

confidence: 99%

“…2 Typically, clinical signs develop at 3 to 4 months of age but may be observed as early as 2 months of age and as late as the time of physeal closure. [1][2][3] Clinical gait deficits directly correlate with the extent of skeletal involvement, and the range of clinical signs can vary from mild limping in minimally affected animals to reluctance to move and an inability to stand in severely affected animals. 4 Hypertrophic osteodystrophy generally affects the radii, ulnas, and tibias; however, lesions may develop in rapidly growing long bones throughout the appendicular skeleton and occasionally in the axial skeleton (including the maxilla, mandible, costochondral junctions of the ribs, scapulas, and ilia).…”

Section: Commentsmentioning

confidence: 99%

See 2 more Smart Citations

Pathology in Practice

Joiner¹,

Montgomery²

2011

javma

View full text Add to dashboard Cite

HistoryA 16-week-old sexually intact male Great Dane was evaluated at the Auburn University Small Animal Veterinary Teaching Hospital because it was nonambulatory and had signs of moderate to severe pain in all limbs. The dog had a history of a rapidly progressive, bilateral hind limb lameness accompanied by lethargy, anorexia, and intermittent fever during the preceding week; in general, the dog had become and remained recumbent. The dog was usually fed a standard ration of commercial dog food, and dietary supplements were not provided. Clinical and Gross FindingsAt the initial evaluation, the dog was non-weight bearing in all 4 limbs and breathing was labored. Radiography of all 4 limbs was performed, and bilaterally symmetric linear radiolucent zones were evident in the distal radial and ulnar metaphyses. A CBC revealed leukopenia (5.02 X 10 3 cells/ µL; reference range, 6.0 X 10 3 cells/µL to 17.0 X 10 3 cells/ µL) attributed to neutropenia (2,058 cells/µL; reference range, 3,000 to 11,400 cells/µL) with a left shift (904 bands/ µL; reference range, 0 to 300 bands/µL). Results of serum biochemical analyses were indicative of bone and muscle This report was submitted In cooperation with damage, with high activities of alkaline phosphatase (287 U/L; reference range, 3.5 to 95 U/L) and creatine kinase (1,092 U/L; reference range, 92 to 357 U/L) and high concentrations of calcium (19.6 mg/dL; reference range, 9.5 to 11.8 mg/dL) and phosphorus (10.3 mg/dL; reference range, 3.3 to 5.8 mg/dL). Within 12 hours after the initial evaluation, signs of pain in the limbs and respiratory distress intensified; rectal temperature was 40.4°C (104.8°F). The dog developed cardiopulmonary arrest, and resuscitation attempts were unsuccessful.A complete necropsy of the dog revealed bilateral enlargement of the proximal and distal physes and metaphyses of the radii, ulnas, carpal bones, tibias, fibulas, and tarsal bones. Subjacent to the physeal cartilage, the metaphyseal architecture was obscured by 1.0-to 4.0-mmwide bands of pale yellow, friable material admixed with fibrinous strands and bony spicula (Figure 1). These linear zones of fibrinonecrotic debris sometimes impinged on the overlying physes and were often surrounded by locally extensive regions of hemorrhage. A few of the physes were irregular or serpiginous, and thin finger-like extensions of cartilage projected slightly into the respective epiphysis and metaphysis. The radial, ulnar, and tibial metaphyses were surrounded by subperiosteal hemorrhage that slightly elevated the periosteum and extended along the outer bone cortex. These lesions were more severe in the distal physes of the affected bones.Formulate differential diagnoses from the history, clinical findings, and Figure 1-then turn the page → Figure 1-Photograph of a longitudinal section of the distal portion of a tibia obtained during the necropsy of a Great Dane that was evaluated because of progressive, bilateral, non-weight-bearing lameness, lethargy, anorexia, and intermittent fever. Notice that there is ...

show abstract

Section: Commentsmentioning

confidence: 99%

Section: Commentsmentioning

confidence: 99%

Section: Commentsmentioning

confidence: 99%

See 1 more Smart Citation

Pathology in Practice

Joiner¹,

Montgomery²

2011

javma

View full text Add to dashboard Cite

show abstract

“…HOD has been identified in 40 breeds of dog (Munjar and others 1998), with most breeds represented sporadically within the veterinary literature. The disease has affected entire litters of Weimaraner puppies (Abeles and others 1999) with clinical signs typically developing at three to four months of age, though they have been observed as early as two months of age and as late as the time of physeal closure (Muhlbauer and Kneller 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The disease has affected entire litters of Weimaraner puppies (Abeles and others 1999) with clinical signs typically developing at three to four months of age, though they have been observed as early as two months of age and as late as the time of physeal closure (Muhlbauer and Kneller 2013). Male dogs are at 2.3 times greater risk of developing the condition than female dogs, and the Great Dane is over-represented in the reported population (Munjar and others 1998). …”

Section: Discussionmentioning

confidence: 99%

Hypertrophic osteodystrophy in a dog imaged with CT

Hill¹,

Scudder

Glanemann

et al. 2015

Vet Record Case Reports

View full text Add to dashboard Cite

A seven-month-old male neutered cross-breed dog presented with non-specific signs of lethargy, pyrexia and pain on manipulation of the limbs, which progressed over a period of 24 hours to a non-ambulatory state with pain over multiple metaphyses. The patient underwent diagnostic imaging examinations, including radiography and CT, and arthrocentesis was performed, which demonstrated a sterile, neutrophilic infiltrate. On the basis of diagnostic tests, a diagnosis of hypertrophic osteodystrophy was made. The patient was managed initially with non-steroidal anti-inflammatory medication and adjunctive analgesia. The patient failed to respond to this protocol and hence was changed onto a tapering course of steroids initially at immunosuppressive levels to which he responded well. This case report provides the first description of hypertrophic osteodystrophy using CT and supports the use of arthrocentesis in the diagnostic plan for suspected cases of hypertrophic osteodystrophy in the dog.

show abstract

References

2018

Breed Predispositions to Disease in Dogs and Cats

View full text Add to dashboard Cite

Comparison of Risk Factors for Hypertrophic Osteodystrophy, Craniomandibular Osteopathy and Canine Distemper Virus Infection

Cited by 31 publications

References 18 publications

Pathology in Practice

Pathology in Practice

Hypertrophic osteodystrophy in a dog imaged with CT

References

Contact Info

Product

Resources

About