Comparison of reversed-phase, hydrophilic interaction, and porous graphitic carbon chromatography columns for an untargeted toxicometabolomics study in pooled human liver microsomes, rat urine, and rat plasma
Selina Hemmer,
Sascha K. Manier,
Lea Wagmann
et al.
Abstract:Introduction
Untargeted metabolomics studies are expected to cover a wide range of compound classes with high chemical diversity and complexity. Thus, optimizing (pre-)analytical parameters such as the analytical liquid chromatography (LC) column is crucial and the selection of the column depends primarily on the study purpose.
Objectives
The current investigation aimed to compare six different analytical columns. First, by comparing the chromatogr… Show more
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