Comparison of reversed-phase and ion-pair chromatography for the determination of strychnine in animal tissues

Johnston, John J.; Petty, Eric E.; Okuno, Iwao; Nolte, Dale L.

doi:10.1016/0378-4347(95)00156-d

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…Several methods are described for the determination of strychnine, using paper chromatography after dissolution of the alkaloidal extract from Nux-vomica seed in chloroform [8], or liquid-liquid extraction followed by either thin-layer chromatography [9], high performance thin-layer chromatography [10], gas chromatography [2,6,[11][12][13][14][15] or liquid chromatography [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Application of solid phase microextraction to the determination of strychnine in blood

Barroso¹,

Gallardo²,

Margalho³

et al. 2005

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Application of solid phase microextraction to the determination of strychnine in blood

Barroso¹,

Gallardo²,

Margalho³

et al. 2005

Journal of Chromatography B

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“…Numerous methods exist for quantifying strychnine using HPLC in baits [9,10], animal tissues, vomitus, or stomach contents [9,11,12], and a few exist for analyzing hu- man urine or blood samples as strychnine has been used to treat non-ketotic hyperglycinemic infants [13,14] or human forensic applications [15]. Methods using both normal phase chromatography [12][13][14] and reverse phase chromatography with [10,11,16,17] or with out an ion-pairing reagent [9,16] have been developed.…”

Section: Introductionmentioning

confidence: 99%

Development of a high performance liquid chromatography/mass spectroscopy method for the determination of strychnine concentrations in insects used to assess potential risks to insectivores

Stahl

ARJO²,

WAGNER³

et al. 2004

Journal of Chromatography B

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A high performance liquid chromatography/mass spectrometry (HPLC/MS) method was developed in support of a study to assess potential tertiary risks posed to insectivores by strychnine baited pocket gophers (Thomomys sp.). Necropholous insects are primary consumers of pocket gopher carcasses. A field study was conducted to collect insects from strychnine-baited and control pocket gopher carcasses. The majority of the insects collected were from the orders Diptera (flies, assayed separately as adults and larvae), Coleoptera (beetles), and Hymenoptera (ants and wasps, assayed separately). Samples (0.5 g) were extracted in acetic acid (2%) and analyzed with the mass spectrometer configured for tandem mass spectrometry. For most of the samples the strychnine concentrations were less than the method limit of detection. However, strychnine concentrations as high as 0.338, 0.341, 0.698, and 0.034 g/g were detected in ants, fly adults, fly larvae, and beetles, respectively. This information collected with the HPLC/MS method is critical for assessing potential non-target hazards for insectivores.

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“…Analytical methods were developed and applied to determine purity of technical materials, concentrations of toxicants in baits, and residues in carcasses of test animals or nontarget animals experimentally exposed. Important papers include Johns and Thompson (1979), Kimball and Mishalanie (1993), Johnston et al (1995), Mauldin et al (1996), Johnston et al (1997), Goldade et al (1998), andMauldin et al (1999). As equipment and technology for chemical analyses continued to improve, the need for such information also continued to increase -particularly for pesticide registration and other regulatory purposes related to environmental exposure and human or animal safety (Bullard et al 1975, Bruggers et al 1995, Goodall et al1998).…”

Section: Analytical Chemistry Methodsmentioning

confidence: 99%

Rats! Foiled Again: A History of Rodent Control Methods Development at the National Wildlife Research Center

Fagerstone¹,

Fall²,

Witmer³

et al. 2012

vertebrate_pest_conference

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The National Wildlife Research Center (NWRC) and its predecessor laboratories have a long history of developing materials and methods for managing rodents and the damage they cause. The NWRC has been influential in exploring, developing, and maintaining legal uses of many traditional field rodenticides such as strychnine and zinc phosphide. Products have been developed for managing rodents in a variety of locales, and for managing a variety of species, from commensal rodents in urban areas, to pocket gophers and mountain beaver in forests, prairie dogs and ground squirrels on rangelands, and nutria and beaver in wetlands. Considerable research has also been conducted on developing methods of managing rodents in underdeveloped countries. Recent efforts by NWRC have focused on development of tools for managing invasive rodents in conservation areas such as island ecosystems and development of alternative, nonlethal control methods.

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Comparison of reversed-phase and ion-pair chromatography for the determination of strychnine in animal tissues

Cited by 11 publications

References 4 publications

Application of solid phase microextraction to the determination of strychnine in blood

Application of solid phase microextraction to the determination of strychnine in blood

Development of a high performance liquid chromatography/mass spectroscopy method for the determination of strychnine concentrations in insects used to assess potential risks to insectivores

Rats! Foiled Again: A History of Rodent Control Methods Development at the National Wildlife Research Center

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