Comparison of retinal thickness measurements and segmentation performance of four different spectral and time domain OCT devices in neovascular age-related macular degeneration

Mylonas, Georgios; Ahlers, C.; Malamos, Panagiotis; Golbaz, I.; Deák, Gábor; Schuetze, C.; Sacu, Stefan; Schmidt‐Erfurth, Ursula

doi:10.1136/bjo.2008.153643

Cited by 71 publications

(57 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the use of custom-built segmentation algorithms along with open-source image applications could also facilitate the transformation of data obtained by different devices. 33 In view of the higher price of FD-OCT systems and the use of TD-OCT worldwide, we believe our OCTRIMA software can be of substantial value in future studies of macular pathophysiology and might also perform well for FD-OCT images in the future.…”

Section: Discussionmentioning

confidence: 99%

Comparison of retinal thickness by Fourier-domain optical coherence tomography and OCT retinal image analysis software segmentation analysis derived from Stratus optical coherence tomography images

et al. 2011

View full text Add to dashboard Cite

Abstract. Purpose: To compare thickness measurements between Fourier-domain optical coherence tomography (FD-OCT) and time-domain OCT images analyzed with a custom-built OCT retinal image analysis software (OCTRIMA). Methods: Macular mapping (MM) by StratusOCT and MM5 and MM6 scanning protocols by an RTVue-100 FD-OCT device are performed on 11 subjects with no retinal pathology. Retinal thickness (RT) and the thickness of the ganglion cell complex (GCC) obtained with the MM6 protocol are compared for each early treatment diabetic retinopathy study (ETDRS)-like region with corresponding results obtained with OCTRIMA. RT results are compared by analysis of variance with Dunnett post hoc test, while GCC results are compared by paired t-test. Results: A high correlation is obtained for the RT between OCTRIMA and MM5 and MM6 protocols. In all regions, the StratusOCT provide the lowest RT values (mean difference 43 ± 8 μm compared to OCTRIMA, and 42 ± 14 μm compared to RTVue MM6). All RTVue GCC measurements were significantly thicker (mean difference between 6 and 12 μm) than the GCC measurements of OCTRIMA. Conclusion: High correspondence of RT measurements is obtained not only for RT but also for the segmentation of intraretinal layers between FD-OCT and StratusOCT-derived OCTRIMA analysis. However, a correction factor is required to compensate for OCT-specific differences to make measurements more comparable to any available OCT device. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of retinal thickness by Fourier-domain optical coherence tomography and OCT retinal image analysis software segmentation analysis derived from Stratus optical coherence tomography images

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Abban minden szerző egyetért, hogy spectral-domain készülékkel nagyobb retinavastagsági értékeket kapunk, mint time-domain készülékkel [5,7,8,9,10,11,12,13,14,15,16]. Ez a különbség az egyes rendszerek különböző szegmentációs algoritmusainak különbségeiből adódik.…”

Section: Megbeszélésunclassified

Comparison of thickness values in nine macular subfields using time-domain and spectral-domain optical coherence tomography

et al. 2013

View full text Add to dashboard Cite

Célkitűzés: Retinavastagság-értékek összehasonlítása spectral-domain (Cirrus HD-OCT) és time-domain (Stratus OCT) optikai koherencia tomog ráfi ás készülékkel. Módszer: Retinavastagság-mérések történtek a kilenc ETDRS macularis almezőben 20 egészséges személy azonos oldali szemén mindkét készülékkel. A Cirrus HD-OCT eseté-ben a Macular Cube 512×128 és a Macular Cube 200×200 protokollt, a Stratus OCT készülékkel a Fast Macular Thickness Map protokollt használtuk. Vizsgáltuk mindhárom mérési sorozat reprodukálhatóságát, és a mérések át-lagértékeit minden almezőben összehasonlítottuk egymással. Eredmények: A Stratus OCT-vel végzett mérési eredmé-nyek minden almezőben szignifi kánsan alacsonyabbak voltak, mint a Cirrus esetében (p<0,001). A Cirrus HD-OCT két különböző protokolljával végzett mérések eredményei között a korrelációs együttható 0,977 volt. Következtetések: A Cirrus HD-OCT használatával lényegesen jobb reprodukálhatóságot fi gyeltünk meg, mint a Stratus OCT eseté-ben. A Cirrus HD-OCT használatával a mérési értékek szignifi kánsan magasabbak minden almezőben, mint a Stratus OCT esetében. Különböző OCT-készülékek használatával jelentősen különböző mérési eredményekhez juthatunk, ezért az adatok összehasonlításakor óvatosság szükséges. Orv. Hetil., 154(52), 2059-2064. Kulcsszavak: optikai koherencia tomográfi a, macula, retina, vastagság Comparison of thickness values in nine macular subfi elds using time-domain and spectral-domain optical coherence tomographyAim: To compare macular thickness measurements with spectral-domain (Cirrus HD-OCT) and time-domain (StratusOCT) optical coherence tomography. Method: Macular thickness was measured in nine ETDRS subfi elds in the same eye of 20 healthy subjects using both instruments. Using Cirrus HD-OCT both the Macular Cube 512×128 and Macular Cube 200×200 protocol, using StratusOCT the Fast Macular Thickness Map protocol was performed. Reproducibility of all three measurement series was assessed and the average of the measurement series was compared on each fi eld. Results: Measurement values obtained by StratusOCT were signifi cantly lower than those obtained by Cirrus HD-OCT (p<0.001) in all subfi elds. Correlation coeffi cient between the results obtained by the two protocols of Cirrus HD-OCT was 0.977. Conclusions: By using Cirrus HD-OCT we could observe better repeatability than

show abstract

“…Clinical ophthalmic imaging system manufacturers like Heidelberg and Topcon provide both OCT [9,10] and AF [11,12] instruments and have the option to combine these two imaging modalities. In non-ophthalmic imaging field, several groups have investigated the combination of OCT with AF imaging in different applications including cancer detection [13][14][15][16], heart imaging [17], morphological and biochemical tissues characterization [18,19], lung tissue imaging [20], and tissue imaging with needle probes [7,8,[13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous optical coherence tomography and lipofuscin autofluorescence imaging of the retina with a single broadband light source at 480nm

Jiang

Liu

et al. 2014

Biomed. Opt. Express

View full text Add to dashboard Cite

Abstract:We accomplished spectral domain optical coherence tomography and auto-fluorescence microscopy for imaging the retina with a single broadband light source centered at 480 nm. This technique is able to provide simultaneous structural imaging and lipofuscin molecular contrast of the retina. Since the two imaging modalities are provided by the same group of photons, their images are intrinsically registered. To test the capabilities of the technique we periodically imaged the retinas of the same rats for four weeks. The images successfully demonstrated lipofuscin accumulation in the retinal pigment epithelium with aging. The experimental results showed that the dual-modal imaging system can be a potentially powerful tool in the study of age-related degenerative retinal diseases. 1178-1181 (1991). 2. A. F. Fercher, "Optical coherence tomography," J. Biomed. Opt. 1(2), 157-173 (1996). 3. N. Ramanujam, "Fluorescence spectroscopy of neoplastic and non-neoplastic tissues," Neoplasia 2(1-2), 89-117 (2000). 4. W. Denk, J. H. Strickler, and W. W. Webb, "Two-photon laser scanning fluorescence microscopy," Science 248(4951), 73-76 (1990 7144-7158 (2006). 6. C. J. Kennedy, P. E. Rakoczy, and I. J. Constable, "Lipofuscin of the retinal pigment epithelium: a review," Eye (Lond.) 9(6), 763-771 (1995) 19653-19659 (2011). 31. S. Jiao, R. Knighton, X. Huang, G. Gregori, and C. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13(2), 444-452 (2005). 32. D. Grotte, V. Mattox, and R. Brubaker, "Fluorescent, physiological and pharmacokinetic properties of fluorescein glucuronide," Exp. Eye Res. 40(1), 23-33 (1985). 33. H. Xu, M. Chen, A. Manivannan, N. Lois, and J. V. Forrester, "Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice," Aging Cell 7(1), 58-68 (2008).

show abstract

Comparison of retinal thickness measurements and segmentation performance of four different spectral and time domain OCT devices in neovascular age-related macular degeneration

Cited by 71 publications

References 20 publications

Comparison of retinal thickness by Fourier-domain optical coherence tomography and OCT retinal image analysis software segmentation analysis derived from Stratus optical coherence tomography images

Comparison of retinal thickness by Fourier-domain optical coherence tomography and OCT retinal image analysis software segmentation analysis derived from Stratus optical coherence tomography images

Comparison of thickness values in nine macular subfields using time-domain and spectral-domain optical coherence tomography

Simultaneous optical coherence tomography and lipofuscin autofluorescence imaging of the retina with a single broadband light source at 480nm

Contact Info

Product

Resources

About