Comparison of resistance to protein adsorption and stability of thin films derived from α-hepta-(ethylene glycol) methyl ω-undecenyl ether on HSi(111) and HSi(100) surfaces

Si–C linked oligo(ethylene glycol) layers in silicon-based photonic crystals: Optimization for implantable optical materials

“…Cai [26] and Hamers [30] have independently reported evidence for improved resistance against nonspecific adsorption of proteins on silicon with increasing number of ethylene glycol (EG) units. EG 3 containing monolayers were found to be protein resistant on gold but failed to adequately protect silver and silicon surfaces [29,33]. Work by Herrwerth et al [34] on metal surfaces confirmed the importance of chain conformation in protein resistance and attributed protein resistance to internal and external hydrophilicity (via water binding within OEG chains and terminal hydroxyl groups).…”

“…Since the pioneering work of Whitesides et al [24], oligo(ethylene glycol) (OEG) moieties in self assembled monolayers have proven a robust and versatile approach to combat non-specific adsorption. The interest in silicon as a sensor material has led to significant research effort into employing OEG molecules in conjunction with hydrosilylation chemistry [22,[25][26][27][28][29][30][31][32]. Cai [26] and Hamers [30] have independently reported evidence for improved resistance against nonspecific adsorption of proteins on silicon with increasing number of ethylene glycol (EG) units.…”

“…To develop a suitable strategy for protecting the underlying silicon surface from oxidation whilst resisting nonspecific protein adsorption, we used a single step method reported previously [22,[25][26][27][28][29][30][31][32] as a starting point. Hydrosilylation of undecenyl tri(ethylene glycol) and undecenyl hexa(ethylene glycol) monomethyl ethers (C11EG n Me, n ¼ 3, 6) are compared to dodecene (C12) as a model hydrophobic interface for protein adsorption within the porous filter (Fig.…”

Forming Antifouling Organic Multilayers on Porous Silicon Rugate Filters Towards In Vivo/Ex Vivo Biophotonic Devices

“…[24] For the former, covalent modification of surfaces with molecules containing oligo(ethylene oxide) (OEO) moieties has been demonstrated as a robust chemical methodology to reduce biofouling [25] and recently, derivatization of silicon surfaces with OEO molecules has been demonstrated. [26][27][28][29][30][31] No reports on this antifouling chemistry in porous silicon structures have yet been made.…”

Preparation, characterization, resistance to protein adsorption, and specific avidin–biotin binding of poly(amidoamine) dendrimers functionalized with oligo(ethylene glycol) on gold

“…Recently, we have demonstrated a new method for nanopatterning of biomolecules on surfaces, based on OEG monolayers covalently bonded to silicon surfaces via robust Si-C bonds, which can reduce the adsorption of fibrinogen to less than 3% monolayer [39][40][41]. Upon conductive atomic force microscopy (c-AFM) nanolithography on such films, high density nanometric spots presenting carboxylic acid groups that serve as templates for attaching biomolecules were generated [40].…”