1959
DOI: 10.1152/ajplegacy.1959.197.6.1297
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Comparison of renal excretion of rubidium and potassium

Abstract: The simultaneous renal clearances of rubidium and potassium were studied during the infusion of solutions of rubidium chloride into intact anesthetized dogs. The effects of prior loading with potassium were studied, as were also the responses to acute administration of acetazoleamide and meralluride. It was observed that the clearance of rubidium was usually slightly less than that of potassium and tended under most circumstances to vary in parallel with it. During infusion of RbCl the clearance of rubidium wa… Show more

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Cited by 24 publications
(8 citation statements)
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“…These latter experiments revealed immediate rises in plasma potassium as rubidium entered cells (5). Increased renal excretion of potassium was shown to be the result of the hyperkalemia, there being no evidence for any direct effect of rubidium on renal tubular handling of potassium (6). Thus it would appear likely that in the present experiments transient elevations of plasma potassium were responsible for the kaluresis but had been dissipated in the 16 hours elapsing between the last load of rubidium and the time of blood sampling.…”
Section: Discussionmentioning
confidence: 92%
“…These latter experiments revealed immediate rises in plasma potassium as rubidium entered cells (5). Increased renal excretion of potassium was shown to be the result of the hyperkalemia, there being no evidence for any direct effect of rubidium on renal tubular handling of potassium (6). Thus it would appear likely that in the present experiments transient elevations of plasma potassium were responsible for the kaluresis but had been dissipated in the 16 hours elapsing between the last load of rubidium and the time of blood sampling.…”
Section: Discussionmentioning
confidence: 92%
“…It appears that Rb is less mobile than K in the kidneys, since values of Q( Rb/K)( t ) for the kidneys increase from less than 1 soon after injection to about 3 at 45 min and settle near 1.6 within a few hours (Strauss et al 1975;Love et al 1954;Kilpatrick et al 1956;Mraz and Patrick 1957). We estimate from studies comparing uptake or clearance of Rb and K by the kidneys of mice, rats, rabbits and dogs (Strauss et al 1975;Moreno and Diamond 1974;Greger 1981;Kunin et al 1959;Kilpatrick et al 1956;Mraz and Patrick 1957) that Rb is taken up by kidney cells from the lumen and peritubular capillaries at rates about 0.55-0.95 times those of K. We have assigned an Rb extraction fraction for the kidneys of 0.85 because it is in the range of values observed by Mullani et al (1986) but slightly less than the value used earlier for K. This yields an inflow rate from plasma of 240 d-' (0.85 times a plasma flow of 0.19 X 1500 plasma volumes d-') and an outflow rate to plasma of 120 d-' (the total inflow as a fraction of total-body Rb is 0.003 times 240 d-' or 0.72 d-' , and since the kidneys contain 0.006 of total-body Rb, the outflow rate must be 0.72 d-'/0.006 or 120 d-I).…”
Section: Kidneysmentioning
confidence: 99%
“…Fast muscle fibers are more permeable to K via passive transport and probably receive little K by active transport. The greater values of Q( Rb/K) for slow muscle would then result from the more favorable competition of Rb with K during active transport than during passive transport (Kernan 1969;Kernan 1972;Kernan and McDermott 1973;Kunin et al 1959).…”
Section: Muscle (Skeletal)mentioning
confidence: 99%
“…Ru bidium administered exogenously is reportedly distributed in various tissues including the brain (7-9) and is excreted very slowly (10,11). Repeated administrations of rubidium in certain doses, therefore, result in exhibiting toxic effects such as a decrease in body weight (8,12) and tetanic spasms or convulsion (12)(13)(14)(15).…”
Section: Discussionmentioning
confidence: 99%