Comparison of remnant cholesterol levels estimated by calculated and measured LDL-C levels in Chinese patients with coronary heart disease

Xiang, Qunyan; Tian, Feng; Lin, Qiuzhen; Du, Xiao; Zhang, Shilan; Gui, Yajun; Guo, Liling; Xu, Jin; Zhu, Liyuan; Wen, Tie; Liu, Ling

doi:10.1016/j.cca.2019.09.020

Cited by 23 publications

(21 citation statements)

References 35 publications

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“…Blood samples were analyzed as described previously ( 11 , 18 ). Briefly, serum levels of TC, triglyceride (TG), and HDL-C were measured by a laboratory technician who had no knowledge of this study.…”

Section: Methodsmentioning

confidence: 99%

Change in Postprandial Level of Remnant Cholesterol After a Daily Breakfast in Chinese Patients With Hypertension

et al. 2021

Front. Cardiovasc. Med.

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Background: Hypertension (HBP) is usually accompanied by hypertriglyceridemia that represents the increased triglyceride-rich lipoproteins and cholesterol content in remnant lipoproteins [i.e., remnant cholesterol (RC)]. According to the European Atherosclerosis Society (EAS), high RC (HRC) is defined as fasting RC ≥0.8 mmol/L and/or postprandial RC ≥0.9 mmol/L. However, little is known about postprandial change in RC level after a daily meal in Chinese patients with HBP.Methods: One hundred thirty-five subjects, including 90 hypertensive patients (HBP group) and 45 non-HBP controls (CON group), were recruited in this study. Serum levels of blood lipids, including calculated RC, were explored at 0, 2, and 4 h after a daily breakfast. Receiver operating characteristic (ROC) curve analysis was used to determine the cutoff point of postprandial HRC.Results: Fasting TG and RC levels were significantly higher in the HBP group (P < 0.05), both of which increased significantly after a daily meal in the two groups (P < 0.05). Moreover, postprandial RC level was significantly higher in the HBP group (P < 0.05). ROC curve analysis showed that the optimal cutoff point for RC after a daily meal to predict HRC corresponding to fasting RC of 0.8 mmol/L was 0.91 mmol/L, which was very close to that recommended by the EAS, i.e., 0.9 mmol/L. Fasting HRC was found in 31.1% of hypertensive patients but not in the controls. According to the postprandial cutoff point, postprandial HRC was found in approximately half of hypertensive patients and ~1-third of the controls.Conclusion: Postprandial RC level increased significantly after a daily meal, and hypertensive patients had higher percentage of HRC at both fasting and postprandial states. More importantly, the detection of postprandial lipids could be helpful to find HRC.

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Section: Methodsmentioning

confidence: 99%

Change in Postprandial Level of Remnant Cholesterol After a Daily Breakfast in Chinese Patients With Hypertension

et al. 2021

Front. Cardiovasc. Med.

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“…All blood samples were centrifuged at 4 ℃ 3000 rpm for 15 min. Serum levels of TC and triglyceride(TG) were measured by automated enzymatic assays, and that of HDL-C were measured by a commercially available direct method, on a HITACHI 7170A analyzer(Instrument Hitachi Ltd., Tokyo, Japan) by a laboratory technician who had no idea of this study [9,16]. LDL-C level was calculated using the…”

Section: Laboratory Assaysmentioning

confidence: 99%

Change in Postprandial Level of Remnant Cholesterol After a Daily Breakfast in Chinese Patients With Hypertension

et al. 2021

Preprint

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Background: Hypertension(HBP) is usually accompanied by hypertriglyceridemia that represents the increased triglyceride-rich lipoproteins(TRLs) and their cholesterol content(i.e. remnant cholesterol, RC). According to the European Atherosclerosis Society(EAS), high RC(HRC) is defined as fasting RC ≥ 0.8mmol/L or/and postprandial RC ≥ 0.9mmol/L. However, little was known about postprandial change in RC level after a daily meal in Chinese patients with HBP. Methods: One hundred and thirty-five subjects, including 90 hypertensive patients(HBP group) and 45 non-HBP controls(CON group), were recruited in this study. Serum levels of blood lipids, including calculated RC, were explored at 0, 2, and 4 h after a daily breakfast. Receiver operating characteristic(ROC) curve analysis was used to determine the cut-off point of postprandial HRC.Results: TG and RC levels increased significantly after a daily meal in two groups(P<0.05). However, postprandial RC level was significantly higher in HBP group( P<0.05). ROC curve analysis showed that the optimal cut-off point for RC after a daily meal to predict HRC in corresponding to fasting RC 0.8 mmol/L was 0.91 mmol/L, which was very close to that recommended by the EAS, i.e. 0.9mmol/L. Fasting HRC was found in 31.1% hypertensive patients but not in the controls. According to the postprandial cut-off point, postprandial HRC was found in about half of hypertensive patients and about one third of controls. Conclusion: Postprandial RC level increased significantly after a daily meal and hypertensive patients had higher percentage of HRC. More importantly, the detection of postprandial lipids is helpful to find HRC.

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“…Confirmatory reports have been published in Chinese populations [23] and in selected groups as exemplified by type 2 diabetes [24]. Nonetheless, the strength of the evidence is limited by methodological issues, as the concentration of remnant particles was estimated indirectly using levels of either plasma triglycerides or calculated remnant cholesterol (as total cholesterol -LDLcholesterol -HDL-cholesterol).…”

Section: Epidemiologic Studies Of Remnant Cholesterolmentioning

confidence: 99%

“…Plasma triglyceride is not an ideal marker, as it may be determined in part by the presence of other particles that are not strongly associated with atherosclerosis (ie. chylomicrons and large VLDLs); a similar comment applies to determination of remnant cholesterol levels when measured in a corresponding manner (14,19,20,21,(22)(23)(24). In addition, the contribution of remnants could be under-represented in many studies, as determinations have frequently been performed under fasting conditions.…”

Section: Epidemiologic Studies Of Remnant Cholesterolmentioning

confidence: 99%

Remnant lipoproteins: are they equal to or more atherogenic than LDL?

Aguilar-Salinas

Chapman

2020

Current Opinion in Lipidology

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Purpose of review To critically appraise new insights into the biology of remnant lipoproteins and their putative role in the pathophysiology of atherosclerotic cardiovascular disease, and to compare the atherogenicity of remnant particles with that of LDL. Recent findings New in vivo stable isotope tracer studies of the kinetics of apoB48-and apoB100-containing lipoproteins in postprandial conditions have revealed that apoB48-containing VLDL accumulated markedly in hypertriglyceridemic subjects. These intestinally-derived particles were cleared slowly, and represented up to 25% of circulating VLDL; as part of the remnant particle population, they may increase cardiovascular risk. Importantly, the PCSK9 inhibitor, evolocumab, was shown to reduce remnant levels (-29%) during the postprandial period in diabetic subjects on statin therapy, an effect which may be additive to that of LDL cholesterol reduction in conferring cardiovascular benefit. In recent Mendelian randomization studies, the effect of lowering triglyceride-rich lipoproteins or LDL cholesterol translated to similar clinical benefit per unit of apoB. Finally, in randomized trials involving statin-treated patients with ASCVD, remnant cholesterol levels were associated with coronary atheroma progression independently of LDL cholesterol. Summary Overall, data from observational studies in large cohorts, Mendelian randomization studies, metaregression analyses and post-hoc analyses of randomized trials are consistent with the contention that remnants are highly atherogenic particles and contribute to the atherosclerotic burden in an equivalent manner to that of LDL.

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Comparison of remnant cholesterol levels estimated by calculated and measured LDL-C levels in Chinese patients with coronary heart disease

Cited by 23 publications

References 35 publications

Change in Postprandial Level of Remnant Cholesterol After a Daily Breakfast in Chinese Patients With Hypertension

Change in Postprandial Level of Remnant Cholesterol After a Daily Breakfast in Chinese Patients With Hypertension

Change in Postprandial Level of Remnant Cholesterol After a Daily Breakfast in Chinese Patients With Hypertension

Remnant lipoproteins: are they equal to or more atherogenic than LDL?

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