Comparison of relative forced expiratory volume of one second with dynamic magnetic resonance imaging parameters in healthy subjects and patients with lung cancer

Plathow, Christian; Fink, Christian; Sandner, A.; Ley, Sebastian; Puderbach, Michael; Eichinger, Monika; Schmähl, A.; Kauczor, Hans‐Ulrich

doi:10.1002/jmri.20255

Cited by 19 publications

(15 citation statements)

References 35 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obvious dependence of lung motion and tumor mobility on tumor localization recently has been proposed to be due to reduced compliance of the tissue surrounding the tumor [17,[27][28][29]. Unfortunately, compliance itself still is not sufficiently locally quantifiable on the basis of imaging techniques.…”

Section: Discussionmentioning

confidence: 99%

Therapy monitoring using dynamic MRI: Analysis of lung motion and intrathoracic tumor mobility before and after radiotherapy

et al. 2006

Self Cite

View full text Add to dashboard Cite

A frequent side effect after radiotherapy of lung tumors is a decrease of pulmonary function accompanied by dyspnea due to developing lung fibrosis. The aim of this study was to monitor lung motion as a correlate of pulmonary function and intrathoracic tumor mobility before and after radiotherapy (RT) using dynamic MRI (dMRI). Thirty-five patients with stage I non-small-cell lung carcinoma were examined using dMRI (trueFISP; three images/s). Tumors were divided into T1 and T2 tumors of the upper, middle and lower lung region (LR). Maximum craniocaudal (CC) lung dimensions and tumor mobility in three dimensions were monitored. Vital capacity (VC) was measured and correlated using spirometry. Before RT, the maximum CC motion of the tumor-bearing hemithorax was 5.2 +/- 0.9 cm if the tumor was located in the lower LR (middle LR: 5.5 +/- 0.8 cm; upper LR: 6.0 +/- 0.6 cm). After RT, lung motion was significantly reduced in the lower LR (P < 0.05). Before RT, the maximum CC tumor mobility was significantly higher in tumors of the lower LR 2.5 +/- 0.6 vs. 2.0 +/- 0.3 cm (middle LR; P < 0.05) vs. 0.7 +/- 0.2 cm (upper LR; P < 0.01). After RT, tumor mobility was significantly reduced in the lower LR (P < 0.01) and in T2 tumor patients (P < 0.05). VC showed no significant changes. dMRI is capable of monitoring changes in lung motion that were not suspected from spirometry. This might make the treatment of side effects possible at a very early stage. Changes of lung motion and tumor mobility are highly dependent on the tumor localization and tumor diameter.

show abstract

Section: Discussionmentioning

confidence: 99%

Therapy monitoring using dynamic MRI: Analysis of lung motion and intrathoracic tumor mobility before and after radiotherapy

et al. 2006

Self Cite

View full text Add to dashboard Cite

show abstract

“…[8][9][10] It has been reported that chest wall motion evaluated by MRI is a surrogate marker of pulmonary function tests (PFTs). 11,12 Previous studies using MRI showed fl attening of the diaphragm and its limited and/or paradoxical movement in COPD patients compared with normal subjects. 13,14 MRI can also detect the infl uence of a local lung tumor on chest wall motion.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 MRI can also detect the infl uence of a local lung tumor on chest wall motion. 10,12 We postulated that MRI can visualize slight differences in chest wall motion between predominantly upper and lower emphysema.…”

Section: Introductionmentioning

confidence: 99%

Influence of the distribution of emphysema on diaphragmatic motion in patients with chronic obstructive pulmonary disease

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Dynamic magnetic resonance imaging (dMRI) has been proven to be a reliable tool for visualisation and evaluation of local chest wall movement and respiratory mechanics in healthy volunteers [1][2][3] and patients with lung cancer [4].…”

mentioning

confidence: 99%

Magnetic resonance-compatible-spirometry: principle, technical evaluation and application

Eichinger¹,

Puderbach²,

Smith³

et al. 2007

European Respiratory Journal

View full text Add to dashboard Cite

The aim of this study was to assess the feasibility and accuracy of a novel magnetic resonance-compatible (MRc)-spirometer. The influence of body posture, magnetic resonance (MR)-setting and image acquisition on lung function was evaluated. Dynamic MR imaging (dMRI) was compared with simultaneously measured lung function.The development of the MRc-spirometer was based on a commercial spirometer and evaluated by flow-generator measurements and forced expiratory manoeuvres in 34 healthy nonsmokers (17 females and 17 males, mean age 32.9 yrs). Mean differences between forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated and a sample paired t-test and Bland-Altman plots were generated. A total of 11 subjects underwent different subsequent MRc-spirometric measurements to assess the influence of the components of the MR system on lung function.The mean (95% confidence interval) difference of FEV1 and FVC between the two systems was 0.004 (-0.04-0.04) L and 0.018 (-0.05-0.09) L, respectively. In the subgroup analysis, an influence of the MR-system on FEV1 was found. FEV1 correlated well with the dMRI measurement of the apico-diaphragmatic distance-change after the first second of forced expiration (r50.72).In conclusion, magnetic resonance-compatible-spirometry is feasible, reliable and safe. The magnetic resonance-setting only has a small influence on simultaneously measured forced expiratory volume in one second. Dynamic magnetic resonance imaging measurements correlate well with simultaneously acquired lung function parameters.

show abstract

Comparison of relative forced expiratory volume of one second with dynamic magnetic resonance imaging parameters in healthy subjects and patients with lung cancer

Cited by 19 publications

References 35 publications

Therapy monitoring using dynamic MRI: Analysis of lung motion and intrathoracic tumor mobility before and after radiotherapy

Therapy monitoring using dynamic MRI: Analysis of lung motion and intrathoracic tumor mobility before and after radiotherapy

Influence of the distribution of emphysema on diaphragmatic motion in patients with chronic obstructive pulmonary disease

Magnetic resonance-compatible-spirometry: principle, technical evaluation and application

Contact Info

Product

Resources

About