Comparison of reflectance confocal microscopy and line‐field optical coherence tomography for the identification of basal cell carcinoma

Cinotti, Élisa; Bertello, Martina; Dragotto, Martina; Cartocci, Alessandra; Tognetti, Linda; Cappilli, Simone; Peris, Ketty; Perrot, Jean; Marmol, Véronique Del; Rubegni, Pietro; Suppa, Mariano

doi:10.1111/jdv.19155

Acad Dermatol Venereol

2023

DOI: 10.1111/jdv.19155

|View full text |Cite

Comparison of reflectance confocal microscopy and line‐field optical coherence tomography for the identification of basal cell carcinoma

Élisa Cinotti

Martina Bertello

Martina Dragotto

et al.

Abstract: Dear Editor, Reflectance confocal microscopy (RCM) and line-field confocal optical coherence tomography (LC-OCT) are non-invasive imaging techniques that can help the clinical diagnosis of basal cell carcinoma (BCC). [1][2][3][4][5][6] Although LC-OCT and RCM have been compared for the identification of squamous cell carcinomas, 4 no comparative studies on BCC diagnostic criteria are available. Our study aimed to compare BCC features under RCM and LC-OCT. For this purpose, a retrospective multicentre study was… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article3

Relationship

Self Cite1

Independent2

Authors

Journals

Cited by 3 publications

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Digital imaging of ink spot lentigo: Confocal microscopy and line‐field confocal optical coherence tomography assessment

Salvi,

Cappilli,

Ricci

et al. 2024

JEADV Clinical Practice

View full text Add to dashboard Cite

Dear Editor, The reticulated black solar lentigo was initially described by Bolognia et al. in 1992 as a type of solar lentigo. 1 Ink spot lentigo (ISL), as commonly known, clinically presents as a solitary dark pigmented macule with illdefined margins occurring on the back of fair skin individuals. Due to the peculiar appearance and the common association with multiple solar lentigos, ISL may be difficult to differentiate from melanoma. 1,2 Dermoscopy may show criteria similar to those observed in melanocytic lesions as an irregular thick pigment network, angulated lines and rhomboidal structures, and in these cases biopsy should be considered to rule out malignancy. 2,3 The use of noninvasive imaging techniques, like reflectance confocal microscopy (RCM), increases the diagnostic accuracy of equivocal skin lesions, allowing to obtain greater performances than dermoscopy alone. 4,5 A new digital tool, Line-field confocal optical coherence tomography (LC-OCT), is capable to acquire images/videos of skin lesions in multimodal view (vertical and horizontal), creating also immediate 3D cubes. 6 Pivotal studies reported promising preliminary data for the in vivo diagnosis of skin cancers. [6][7][8] We report RCM and LC-OCT morphological features of consecutive ISLs, correlating in vivo imaging to histopathology. Twenty-five histopathologically confirmed ISLs of 24 patients (14 M, 10 F, mean age: 48 years old, range: 19-82 years old) were investigated by RCM and LC-OCT from January 2023 to January 2024. ISLs were located on the trunk (10/25, 40%), on the face (7/25, 28%), on the lower extremities (4/25, 16%) and upper extremities (4/25, 16%). Dermoscopy showed atypical (thick, unevenly distributed) pigment network with sharp margins (23/25, 92%), and angulated lines (5/

show abstract

Digital imaging of ink spot lentigo: Confocal microscopy and line‐field confocal optical coherence tomography assessment

Salvi,

Cappilli,

Ricci

et al. 2024

JEADV Clinical Practice

View full text Add to dashboard Cite

show abstract

Surgery after sonidegib treatment achieves complete response in locally advanced basal cell carcinoma of the face

Paradisi,

Piccerillo,

Bocchino

et al. 2023

The Journal of Dermatology

Self Cite

View full text Add to dashboard Cite

Basal cell carcinoma accounts for 75% of skin cancers worldwide and is the most common malignancy in Caucasians. Since chronic ultraviolet exposure is the major risk factor for its development, sun‐exposed areas such as the face are frequently affected. The gold‐standard treatment is surgical excision. Radiotherapy may be considered in selected cases such as unresectable primary tumors. In some patients, when the risk of a significant functional/cosmetic deficit advises against both surgery and radiotherapy, target therapy (hedgehog pathway inhibitors) can be administered alone or in a neoadjuvant setting, to reduce the tumor size and make it eligible for surgery. Vismodegib as a neoadjuvant treatment before surgery has been investigated in a single, multicentre, open‐label, phase II trial (VISMONEO); however, sonidegib has not yet been evaluated in this setting. We report the cases of two patients with locally advanced basal cell carcinoma of the face who achieved complete remission with sonidegib followed by a more limited surgical excision than would have been needed without target therapy.

show abstract

Line-Field Confocal Optical Coherence Tomography: A New Skin Imaging Technique Reproducing a “Virtual Biopsy” with Evolving Clinical Applications in Dermatology

Cappilli,

Paradisi,

Di Stefani

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Background: Line-field confocal optical coherence tomography is a novel technology able to reproduce a “virtual biopsy” of the skin. The aim of this review is to explore the application of line-field confocal optical coherence tomography (LC-OCT) in various skin diseases, covering skin cancers, inflammatory and infectious skin diseases, genetic diseases, cosmetic procedures, and less common disorders. Methods: Study selection was conducted based on LC-OCT and using pertinent MeSh terms, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines from inception to March 2024; to evaluate the quality and risk of bias of studies, Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used. Results: the search retrieved 154 papers according to the selection criteria; after removing publications by one or more of the exclusion criteria, a total of 96 studies were found to be suitable for the analysis. Conclusions: Increasing evidence supports the use of LC-OCT as an adjunctive diagnostic tool for the in vivo diagnosis of a variety of skin tumors. As this device can be considered a “bridge” between dermoscopy and histopathology, widening applications in numerous fields of clinical dermatology, including inflammatory skin disease treatment, presurgical mapping, cosmetic procedures, and monitoring of non-invasive therapies, have been explored.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Comparison of reflectance confocal microscopy and line‐field optical coherence tomography for the identification of basal cell carcinoma

Cited by 3 publications

References 10 publications

Digital imaging of ink spot lentigo: Confocal microscopy and line‐field confocal optical coherence tomography assessment

Digital imaging of ink spot lentigo: Confocal microscopy and line‐field confocal optical coherence tomography assessment

Surgery after sonidegib treatment achieves complete response in locally advanced basal cell carcinoma of the face

Line-Field Confocal Optical Coherence Tomography: A New Skin Imaging Technique Reproducing a “Virtual Biopsy” with Evolving Clinical Applications in Dermatology

Contact Info

Product

Resources

About