Comparison of red cell cholinesterase and plasma cholinesterase activities in early detection of organo-phosphorus toxicity in exposed industrial workers in Port Harcourt, Nigeria

Cg, Orluwene; Aa, Ejilemele

doi:10.4314/njm.v15i3.37238

Cited by 2 publications

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“…15 In contrast, others suggested that plasma cholinesterase is more useful in the early detection of organophosphate toxicity than red cell cholinesterase. 16 SChE activity has a high degree of variability from person to person. 17 SChE is subject to high degree of variation induced by hereditary deficiency of this enzyme, liver function, malnutrition, iron deficiency anaemia, drugs such as cocaine, morphine, codeine and succinylcholine making this enzyme a less-than-perfect biomarker for organophosphate poisoning if baseline levels are unknown in an individual.…”

Section: O R G a N O P H O S P H A T E S I N H I B I T T H E E N Z Y M Ementioning

confidence: 99%

Serial Serum Cholinesterase Activities as a Prognostic Factor in Organophosphate Poisoned Patients

Yun¹,

Lee

et al. 2012

Hong Kong Journal of Emergency Medicine

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Organophosphate poisoning is a serious clinical entity and of considerable morbidity and mortality. Several factors have been identified to predict outcomes of organophosphate poisoning. This investigation aims to identify the relationship between the dynamics of serum cholinesterase (SChE) activity and mortality. Methods: In this retrospective study, medical records of all patients with acute organophosphate poisoning were reviewed from January 2001 to December 2009. Clinical features, SChE activity, Glasgow Coma Scale, laboratory findings, electrocardiogram finding, management and their outcomes were examined. Results: A total of 169 patients were included in this study. A total of 55 patients were enrolled. Deceased patients were 8 in number. Absence of an increase in SChE activity was related with mortality in organophosphate poisoned patients (p value=0.036; odds ratio, 5.445; 95% confidence interval, 1.121-26.551). Conclusions: The absence of an increase in SChE activity is associated with higher mortality in organophosphate poisoning. The SChE dynamic activity can provide a guide to physicians in the evaluation and management of organophosphate poisoned patients.

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Section: O R G a N O P H O S P H A T E S I N H I B I T T H E E N Z Y M Ementioning

confidence: 99%

Serial Serum Cholinesterase Activities as a Prognostic Factor in Organophosphate Poisoned Patients

Yun¹,

Lee

et al. 2012

Hong Kong Journal of Emergency Medicine

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“…A study by Orluwene et.al (2006) showed significant reduction in mean plasma cholinesterase activity in chronically exposed subjects (4614 ± 532) when compared with that of the control group (8095 ± 575). 9 There was no statistical difference in the mean red cell cholinesterase activity of the chronically exposed group (7998 ± 948) when compared with that of control (8115 ± 712). 9 In another study by Mekonnen et al (2005) it has been shown that mean values of plasma cholinesterase were generally lower in those exposed to insecticides but this reduction was statistically significant only in sprayers.…”

Section: Discussionmentioning

confidence: 99%

“…8 Many studies have stressed the importance of plasma cholinesterase levels for monitoring OP poisoning. 9,10,11,12 It has been proved that the effect of OP poisoning occurs early and is more marked in plasma cholinesterase than in red cell cholinesterase. A study by Orluwene et.al (2006) showed significant reduction in mean plasma cholinesterase activity in chronically exposed subjects (4614 ± 532) when compared with that of the control group (8095 ± 575).…”

Section: Discussionmentioning

confidence: 99%

Cholinesterase Activity in Health Workers Involved in Handling and Spraying of Organophosphorous Insecticides

Madaan

Ghalaut

Sachdeva

et al. 2011

Int J Med Public Health

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humans, they are responsible for acute poisonings as well as for long term health effects, including cancer and adverse effects on reproduction. Therefore, it is very essential to balance needs with environment and health issues, when using insecticide and pesticide. The vast majority of insecticides targeted at insects, arthropods and nematodes are neurotoxic. They are capable of exerting a broad range of effects that ultimately results in mortality. At the whole organism level the insecticide effect may be either neuroexcitatory leading to hyperactivity, tremors and rigid paralysis or neuroinhibitory causing immobility and flaccid paralysis. 2 Organophosphates and Carbamates are, nowadays, widely used as insecticides and have been considered as potential chemical warfare agents. As an insecticide they are used widely for agriculture, vector control and domestic purpose. 3 Household and agricultural products containing Organophosphorous (OP) pesticides are widely prevalent eg. insecticidal preparations and fertilizers for gardens, surface and room sprays, baits for cockroaches and other insects, shampoos against lice, pet preparations etc. In INTRODUCTIONAn insecticide is a pesticide used against insects in all developmental forms. They may be natural or synthetic chemicals and may act either as ovicide, larvicide or a contact insecticide. The age of chemical insecticides began about 2000 years ago, with the use of natural products like pyrethrum and tobacco. Synthetic insecticides were introduced in 1940 with chemicals like Dichlorophenyl Trichloroethane (DDT). 1 In the present times insecticides are widely used in agriculture, medicine, industry and household. In fact, the boon of agricultural productivity of the present time is partly due to the availability of potent and effective insecticides. But, nearly all insecticides have potential to significantly alter ecosystem; many are toxic to humans and others are concentrated in the food chain. In Cholinesterase Activity in Health WorkersInvolved a B S t r a c tBackground: recent era of agricultural boon is partially the result of extensive use of insecticides and pesticides. But these compounds also have potential to significantly alter the ecosystem and can cause acute poisonings as well as long term detrimental health effects in humans. these compounds can cause toxicity through all routes of exposure. they exert their effect mainly by the inhibition of acetylcholinesterase (ache), which functions by removing acetylcholine (ach) from its postsynaptic receptors. Aims and Objectives: Human exposure to organophosphorous (oP) pesticides can develop lowered cholinesterase levels. the aim of the present study was to estimate the plasma levels of ache in personnel involved in handling of these compounds, during the period of active spraying operations. Methodology: the present study was conducted on 38 subjects working as Multipurpose Health Workers (MPHW groUP-1) and Field Workers (FW groUP-2) involved in the actual spraying of the insecticides, in District roht...

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Comparison of red cell cholinesterase and plasma cholinesterase activities in early detection of organo-phosphorus toxicity in exposed industrial workers in Port Harcourt, Nigeria

Cited by 2 publications

References 0 publications

Serial Serum Cholinesterase Activities as a Prognostic Factor in Organophosphate Poisoned Patients

Serial Serum Cholinesterase Activities as a Prognostic Factor in Organophosphate Poisoned Patients

Cholinesterase Activity in Health Workers Involved in Handling and Spraying of Organophosphorous Insecticides

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