Comparison of recovery times from rocuronium-induced muscle relaxation after reversal with three different doses of sugammadex and succinylcholine during electroconvulsive therapy

Abstract

This study demonstrates the efficacy of rocuronium-sugammadex as an alternative to SCC for muscle relaxation during ECT, and indicates that 8 mg/kg sugammadex produces equally rapid recovery from rocuronium muscular relaxation compared with spontaneous recovery from 1 mg/kg SCC during ECT.

Does Rocuronium-Sugammadex Reduce Myalgia and Headache After Electroconvulsive Therapy in Patients With Major Depression?

“…4 In our study, the doses of rocuronium and sugammadex used were half the dose level of that of Kadoi et al 4 The recovery times were similar to their study. 4 In our study, the doses of rocuronium and sugammadex used were half the dose level of that of Kadoi et al 4 The recovery times were similar to their study.…”

“…4 At a dose of 0.3 mg/kg, rocuronium provides optimal conditions for intubation in many patients. They compared the recovery time and time to onset of spontaneous breathing with that of 1 mg/kg of succinylcholine.…”

“…1 The exact cause of headache and myalgia after ECT is unknown, but they may result from the muscle damage caused by succinylcholine-induced fasciculations. 3 Kadoi et al 4 reversed the deep neuromuscular blockade using various doses (4,8, and 16 mg/kg, respectively) of sugammadex in patients who were treated with 0.6 mg/kg of rocuronium and showed that rocuronium may be a good alternative for succinylcholine during ECT. 3 Kadoi et al 4 reversed the deep neuromuscular blockade using various doses (4,8, and 16 mg/kg, respectively) of sugammadex in patients who were treated with 0.6 mg/kg of rocuronium and showed that rocuronium may be a good alternative for succinylcholine during ECT.…”

“…2 Sugammadex is a new drug of cyclodextrin structure, which can rapidly reverse the neuromuscular blockade induced by the steroidal neuromuscular blockers by selectively encapsulating the blocker molecules. 4 The aim of this study was to investigate the effect of succinylcholine and rocuronium-sugammadex complex on the incidence and severity of headaches and myalgia that occur after ECT and to compare the anesthetic recovery time of the patients. 4 The aim of this study was to investigate the effect of succinylcholine and rocuronium-sugammadex complex on the incidence and severity of headaches and myalgia that occur after ECT and to compare the anesthetic recovery time of the patients.…”

Sugammadex as a reversal agent for neuromuscular block: an evidence-based review

“…However, the combination of rocuronium and sugammadex is a promising new clinical alternative. A single-center study showed that the efficacy of rocuronium followed by 8 mg/kg sugammadex at the end of the ECT treatment was equally effective regarding recovery time compared with succinylcholine alone 33,75…”