Comparison of recombinant and urinary follicle-stimulating hormones over 2000 gonadotropin-releasing hormone antagonist cycles: a retrospective study

Pan, Wei; Tu, Haiting; Jin, Lei; Hu, Cheng; Xiong, Jianwu; Pan, Wei; Yu, Dongyang; Wang, Renjie; Li, Yuehan; Huang, Wei‐Ming; Liao, Shujie

doi:10.1038/s41598-019-41846-2

Cited by 10 publications

(5 citation statements)

References 37 publications

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“…A logistic regression model was used to assess the relationship between FSH regimens and CLBR after adjusting for age, BMI, baseline FSH, and AFC. We selected confounders based on the associations reported with the outcomes of interest [ 6 , 14 – 16 ]. A 1:2 propensity score matching (PSM) was also used to balance factors, including age, BMI, basic FSH, and AFC.…”

Section: Methodsmentioning

confidence: 99%

The cumulative live birth rate of recombinant follicle-stimulating hormone alfa verse urinary human follicle-stimulating hormone for ovarian stimulation in assisted reproductive technology cycles

Chao

Dong

et al. 2022

J Ovarian Res

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Background Infertility remains a significant public health concern. An issue with controlled ovarian stimulation (COS) is the selection of an exogenous gonadotropin (Gn) regimen, which is mainly based on urinary follicle-stimulating hormone (uFSH), recombinant follicle-stimulating hormone alfa (rFSH-alfa), and human menopausal gonadotropin (HMG). In addition, most previous studies focused on the clinical pregnancy rates or live birth rates (LBR) per transfer cycle, but not on the cumulative live birth rate (CLBR) per started cycle. The CLBR, appears to be a more comprehensive and accurate universal measure of IVF treatment success. Therefore, this study aimed to compare the cumulative live birth rate (CLBR) between rFSH-alfa and uFSH regimens for ovarian stimulation. Methods This retrospective cohort study included patients who underwent assisted reproductive technology (ART) with gonadotropin-releasing hormone (GnRH) agonist long protocol between March 2009 and December 2018. Patients were grouped according to the Gn regimen received (rFSH-alfa or uFSH). The main outcome was CLBR, which defined as the first live birth following the use of all fresh and frozen embryos derived from a single COS cycle. Results A total of 1078 cycles were analyzed (314 with rFSH-alfa and 764 with uFSH). The rFSH-alfa group was characterized by a higher number of retrieved oocytes (13.3 vs. 11.0) and transferable embryos (5.0 vs. 4.0), a higher fresh embryo transfer rate (35.0% vs. 26.3%), and a higher multiple birth rate among the fresh embryo transfer cycles (8.2% vs. 2.5%) (P < 0.05). There were no differences in pregnancy rate (32.7% vs. 33.8%) and LBR (25.5% vs. 26.9%) per transfer cycle (P > 0.05). No significant difference was found in clinical outcomes among the frozen embryo transfer cycles (P > 0.05). The CLBR per started cycle in the rFSH-alfa group was higher than in the uFSH group (53.5% vs. 43.1%, P < 0.05). After adjustment, rFSH-alfa was independently associated with a higher CLBR (OR = 1.56; 95%CI = 1.18–2.05; P = 0.0018). Conclusions rFSH-alfa and uFSH have similar pregnancy rates and LBR per transfer cycle, rFSH-alfa might achieve more transferrable blastocysts and higher CLBR per started cycle compared to uFSH.

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Section: Methodsmentioning

confidence: 99%

The cumulative live birth rate of recombinant follicle-stimulating hormone alfa verse urinary human follicle-stimulating hormone for ovarian stimulation in assisted reproductive technology cycles

Chao

Dong

et al. 2022

J Ovarian Res

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“…Ovarian stimulation protocols, including the long agonist protocol, short agonist protocol, and prolonged agonist protocol, were carried out as previously described [ 11 , 12 ],Ai et al [1] . The long agonist protocol (GnRH agonist protocol) was as follows: 0.1 mg/d Triptorelin (Diphereline, IPSEN, Paris, France) was subcutaneously injected from the midluteal phase of the last menstrual cycle.…”

Section: Methodsmentioning

confidence: 99%

“…The study was approved by the ethics committees at the Reproductive Medicine Center of Tongji Hospital, and informed consent was signed before patient participation. According to the IRB of Tongji Hospital, our study did not require an ethics review because all women participating in the study received routine IVF treatment in the hospital and no additional intervention or sampling was performed [ 11 , 12 ].…”

Section: Methodsmentioning

confidence: 99%

Analysis of endometrial thickness patterns and pregnancy outcomes considering 12,991 fresh IVF cycles

Liao

Wang

et al. 2021

BMC Med Inform Decis Mak

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Background Different endometrial patterns have an important effect on the relationship between endometrial thickness (EMT) and clinical pregnancy rate. There is a significant difference in age, selection of cycle protocols, and clinical pregnancy rates among four groups with diverse endometrial patterns. Methods This retrospective study aimed to assess the association between EMT on human chorionic gonadotropin (HCG) administration day and the clinical outcome of fresh in vitro fertilization (IVF). The 5th, 50th, and 95th percentiles for EMT were determined as 8, 11, and 14 mm, respectively. Patients were sub-divided into four groups based on their EMT in different endometrial patterns (Group 1: < 8 mm; Group 2: ≥ 8 and ≤ 11 mm; Group 3: > 11 and ≤ 14 mm; Group 4: > 14 mm). We divided patients into three groups based on their endometrial pattern and evaluated the correlation between EMT and clinical pregnancy rate. Results We found a positive correlation between pregnancy rates and EMT in all endometrial patterns. Multiple logistic regression analysis proved age, duration of infertility, cycle protocols, number of embryos transferred, progesterone on HCG day, endometrial patterns, and EMT have significant effects on clinical pregnancy rates. Meanwhile, there was a significant difference in age, selection of cycle protocols, and clinical pregnancy rates among four groups with diverse endometrial patterns. Conclusions Different endometrial patterns have an important effect on the relationship between EMT and clinical pregnancy rate.

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“…In the last decades, numerous studies have compared recombinant FSH (r-FSH) and urinary FSH (HMG or uFSH) preparations for ovarian stimulation and clinical efficacy [4][5] .These gonadotropins vary according to the amount of LH activity.While human menopausal gonadotropin (HMG) contains both hCG and LH in addition to FSH and 1:1 ratio of FSH and LH bioactivities (e.g, 75 IU each), and uFSH, with less than 1 IU of LH per 75 IU FSH, recombinant follicle stimulation hormone (rFSH) was produced using recombinant DNA technology and has no LH activity [6] .…”

Section: Introductionmentioning

confidence: 99%

The efficiency of recombinant vs. urinary gonadotropin in women of advanced reproductive age

Wang,

Lin,

Zhang

et al. 2024

Preprint

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Purposes: The following study was conducted to determine the efficiency of recombinant vs. urinary gonadotropin in women of advanced reproductive age. Materials and Methods: In our study,we retrospectively compared three ovarian stimulation regimens,HMG(n=199),uFSH(n=198),and rFSH(n=103), in the treatment of 500 infertile women≥35 years old who were subjected to in vitro fertilization/intracytoplasmic sperm injection cycles during a gonadotropin-releasing hormone (GnRH) antagonist protocol. Results: Overall, the mean number of retrieved oocytes was lower in the HMG group compared with uFSH and rFSH groups(P=0.000),while the clinical pregnancy per started cycle (P=0.367), implantation and live birth rate per started cycles were not significantly different.Data were further analyzed by performing separate comparisons of subpopulations in different age range groups, i.e.,35-37,38-40,and>40. Major differences between the three regimens were observed in women who were older than 40 years of age.In this subpopulation,not only the implantation rate was higher in the uFSH group compared with HMG and rFSH groups (P<0.05), but the live birth rate was also significantly higher (P<0.05).In addition,the cost-effectiveness ratio was $434.2 in HMG group, $2,331.1 in uFSH group and $3,284.5 in rFSH group. Conclusions: In women aged 35-39, three gonadotrophins showed no differences in pregnancy outcomes,however,HMG is less expensive and worth recommending.In addition,the implantation rate and live birth rate showed a tendency toward improvement in the woman of advanced reproductive age (age>40) in the uFSH group compared with HMG and rFSH groups.Similarly, this more beneficial effect was also reflected in people with AFC<5.

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Comparison of recombinant and urinary follicle-stimulating hormones over 2000 gonadotropin-releasing hormone antagonist cycles: a retrospective study

Cited by 10 publications

References 37 publications

The cumulative live birth rate of recombinant follicle-stimulating hormone alfa verse urinary human follicle-stimulating hormone for ovarian stimulation in assisted reproductive technology cycles

The cumulative live birth rate of recombinant follicle-stimulating hormone alfa verse urinary human follicle-stimulating hormone for ovarian stimulation in assisted reproductive technology cycles

Analysis of endometrial thickness patterns and pregnancy outcomes considering 12,991 fresh IVF cycles

The efficiency of recombinant vs. urinary gonadotropin in women of advanced reproductive age

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