Comparison of Receptor-Defined Breast Cancer Subtypes Between German and Sudanese Women: A Facility-Based Cohort Study

Sengal, Asmerom T.; Mukhtar, Nada Suliman Haj; Vetter, Martina; Elhaj, Ahmed; Bedri, Shahinaz; Hauptmann, Steffen; Thomssen, Christoph; Mohamedani, Ahmed Abdalla; Wickenhauser, Claudia; Kantelhardt, Eva Johanna

doi:10.1200/jgo.2017.010082

Cited by 15 publications

(26 citation statements)

References 42 publications

(69 reference statements)

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“…Our data revealed that the average age of the Iraqi patients at the time of diagnosis was 12 years younger than their British counterparts. Similar observations were reported in comparative studies on the characteristics of breast cancer among Saudi versus Swiss women [25], and Sudanese versus German [26] and Italian women [27]. In our study, 43.4% of the British patients were diagnosed after the age of 65 years compared to 6.6% among Iraqis.…”

Section: Discussionsupporting

confidence: 91%

“…Cohort studies that compared the clinical and pathological characteristics of breast cancer between Sudanese and German women [26] and between Africans from Central Sudan and Europeans from Northern Italy [27] reported that Sudanese patients were diagnosed at advanced stages exhibiting aggressive breast cancer behavior illustrated in very large tumor sizes and poorly differentiated grades than the German and Italian patients who had significantly lower proportion of positive lymph nodes. A former survey conducted to identify potential molecular differences between breast cancers in Europe and the Middle East demonstrated that the incidence of low-grade disease was 14 times lower in Saudi than Swiss women suggesting differences in genetic susceptibility [25].…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study on the Clinicopathological Profiles of Breast Cancer Among Iraqi and British Patients

Alwan¹,

Kerr²,

Al-Okati³

et al. 2018

TOPHJ

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Background:Breast cancer is the most common cancer in Iraq and the United Kingdom. While the disease is frequently diagnosed among middleaged Iraqi women at advanced stages accounting for the second cause of cancer-related deaths, breast cancer often affects elderly British women yielding the highest survival of all registered malignancies in the UK. Objective:To compare the clinical and pathological profiles of breast cancer among Iraqi and British women; correlating age at diagnosis with the tumor characteristics, receptor-defined biomarkers and phenotype patterns. Methods:This comparative retrospective study included the clinical and pathological characteristics of (1,940) consecutive female patients who were diagnosed with invasive breast cancer from 2014 to 2016 in Iraq (Medical City Teaching Hospital, Baghdad: 635 cases) and UK (John Radcliffe, Oxford and Queen's, BHR University Hospitals: 1,305 cases). The studied parameters in both groups comprised the age of the patient at the time of diagnosis, breast cancer histologic type, grade, tumor size, lymph node status, clinical stage at presentation, Estrogen Receptor (ER), Progesterone Receptor (PR) and HER2 positive tumor contents and the receptordefined breast cancer surrogate subtypes. Results:The Iraqi patients were significantly younger than their British counterparts and exhibited higher trend to present at advanced stages; reflected by larger size tumors and frequent lymph node involvement compared to the British (p<0.00001). They also had worse receptor-defined breast cancer subtypes manifested by higher rates of hormone receptor (ER/PR) negative, HER2 positive tumor contents, Triple Positive and Triple Negative phenotypes (p<0.00001). Excluding HER2 status, the significant differences in the clinical and tumor characteristics between the two populations persisted after adjusting for age among patients younger than 50 years. Conclusion:The remarkable differences in the clinical and tumor characteristics of breast cancer between the Iraqi and British patients suggest heterogeneity in the underlying biology of the tumor which is exacerbated in Iraq by the dilemma of delayed diagnosis. The significant ethnic disparities in breast cancer profiles recommend the prompt strengthening of the national cancer control plan in Iraq as a principal approach to the management of the disease. This comparative retrospective descriptive study included the clinical and pathological characteristics of (1,940) female patients diagnosed with invasive breast cancer in two countries; Iraq (635 cases) and UK (1,305 cases). The Iraqi GroupThis group enrolled 635 consecutive female patients who were diagnosed with breast cancer at the Referral Training Center for Early Detection of Breast Tumors, Medical City Teaching Hospital in Baghdad over a three-year period from 2014 to 2016. Data was extracted from an established information system database developed by the principal investigator under the direct supervision of the International Agency for Research on Cancer (IARC); utili...

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparative Study on the Clinicopathological Profiles of Breast Cancer Among Iraqi and British Patients

Alwan¹,

Kerr²,

Al-Okati³

et al. 2018

TOPHJ

View full text Add to dashboard Cite

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“…Many studies have reported that TNBC are the dominant phenotype in native African women [37][38][39][40] and African Americans [5,41,42] compared with white women but in our patients, Luminal A subtype was slightly dominant. The TNBC are considered more common in younger women and associated with aggressive clinicopathologic characteristics [27,38]. Our ndings corroborate with these reports.…”

Section: Discussioncontrasting

confidence: 67%

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

ADANI-IFE¹,

AMEGBOR²,

DOH³

et al. 2020

Preprint

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Background Molecular classification of breast cancer is an important factor for prognostic and clinical outcome. There are no data regarding molecular breast cancer subtypes among Togolese women. The objective of this study was to evaluate the expression of ER, PR, HER2 and molecular subtypes of breast cancer receptor in Togolese patients and to establish the correlation between clinical and histological data and molecular types. Methods Clinicopathologic data of patients were collected from clinical records. Immunohistochemistry biomarkers (ER, PR and HER2) were assessed in patients who have been diagnosed with invasive breast cancer from March 2016 to March 2020 in the department of oncology. The analysis of variance and the Chi-square Test were used to analyze the data. Results A total of 117 cases were collected. Mean age of patients was 52.05 ± 12.38 with an age range of 30 to 85 years. Half of patients were over 50 years old and majority (70.9%) was postmenopausal. More than half of patients (52.1%) presented with T3-T4tumors.The most common histologic subtype of breast cancer was invasive ductal carcinoma of no special type (95.7%). Tumors grade 2 were predominant (51.3%) followed by grade 3 (42.7%). Advanced carcinomas were found in 69 patients (59%). The percentage of ER+, PR + and HER2 positive tumors was 50.4%, 37.6% and 15.4% respectively. The predominant molecular subtype was Luminal A (42.7%) followed by Triple negative (41.9%), Luminal B subtype (9.4%) and HER2 enriched (6%). There was significant association between tumor size and breast cancer subtypes (p = 0.026) but no correlation was found with age, stage, menopausal status and histologic grade. Conclusion Breast carcinoma in our patients are high grade tumors and are diagnosed at advanced stage. Luminal A and triple negative are the two predominant breast cancer subtypes in Togolese women. Consequently, Receptor testing availability should be a priority in order to offer the best breast cancer treatment.

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“…Many studies have reported that TNBC is the dominant phenotype in native African women [ 37 – 40 ] and African Americans [ 5 , 41 , 42 ] compared with white women. The TNBC is considered more common in younger women and is associated with aggressive clinicopathologic characteristics [ 27 , 38 ]. Our findings corroborate these reports.…”

Section: Discussionmentioning

confidence: 99%

Breast cancer in togolese women: immunohistochemistry subtypes

et al. 2020

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Background Molecular classification of breast cancer is an important factor for prognostic and clinical outcomes. There are no data regarding molecular breast cancer subtypes among Togolese women. The objective of this study was to evaluate the expression of ER, PR, HER2, and molecular subtypes of breast cancer receptors in Togolese patients and to establish the correlation between clinical and histological data and molecular types. Methods Clinicopathologic data of patients were collected from clinical records. Immunohistochemistry biomarkers (ER, PR, and HER2) were assessed in patients who have been diagnosed with invasive breast cancer from March 2016 to March 2020 in the department of oncology. The analysis of variance and the Chi-square Test was used to analyze the data. Results A total of 117 cases were collected. The mean age of patients was 52.05 ± 12.38 with an age range of 30 to 85 years. Half of the patients were over 50 years old and the majority (70.9%) was postmenopausal. More than half of patients (52.1%) presented with T3-T4tumors.The most common histologic subtype of breast cancer was invasive ductal carcinoma of no special type (95.7%). Tumors grade 2 were predominant (51.3%) followed by grade 3 (42.7%). Advanced carcinomas were found in 69 patients (59%). The percentage of ER+, PR+, and HER2 positive tumors was 54.7%, 41%, and 15.4% respectively. The predominant molecular subtype was Triple negative (37.6%), followed by Luminal A (30.8.7%), Luminal B subtype (23.9%), and HER2 enriched (7.7%). There was a significant association between stage and breast cancer subtypes (p 0.025), histologic grade, and subtype (p < 0.0001) but no correlation was found with age, menopausal status, and tumor size. Conclusion Breast carcinoma in our patients are high grade tumors and are diagnosed at an advanced stage. Triple negative and Luminal A are the two predominant breast cancer subtypes in Togolese women. Consequently, Receptor testing availability should be a priority to offer the best breast cancer treatment.

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Comparison of Receptor-Defined Breast Cancer Subtypes Between German and Sudanese Women: A Facility-Based Cohort Study

Cited by 15 publications

References 42 publications

Comparative Study on the Clinicopathological Profiles of Breast Cancer Among Iraqi and British Patients

Comparative Study on the Clinicopathological Profiles of Breast Cancer Among Iraqi and British Patients

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

Breast cancer in togolese women: immunohistochemistry subtypes

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