Comparison of Real-Time Elastography and Multiparametric MRI for Prostate Cancer Detection: A Whole-Mount Step-Section Analysis

Junker, Daniel; Schäfer, Georg; Kobel, Conrad; Kremser, Christian; Bektic, Jasmin; Jaschke, Werner

doi:10.2214/ajr.13.11061

Cited by 34 publications

(25 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The enhanced accuracy of MRI/RTE fusion could be explained by the findings of other working groups evaluating the effect of RTE to MRI. 22,23 Therefore, a higher proportion of cancers could be visualized in prostates larger than 40 cm 3 even though PCa was located in the transitional zone or anterior parts.…”

Section: Discussionmentioning

confidence: 99%

Impact of Real-Time Elastography on Magnetic Resonance Imaging/Ultrasound Fusion Guided Biopsy in Patients with Prior Negative Prostate Biopsies

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of Real-Time Elastography on Magnetic Resonance Imaging/Ultrasound Fusion Guided Biopsy in Patients with Prior Negative Prostate Biopsies

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Data directly comparing SWE and MRI regarding performance rates in anterior tumors, that is, enlarged prostate glands are not available. Nonetheless, Junker et al [26] currently described better PCa DRs for MRI versus standard elastography (strain waves) in enlarged prostate glands and in the anterior part of the prostate. Nonetheless most PCa foci are located in the peripheral zone which is reachable in most cases [27].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Significant Prostate Cancer at Prostate Biopsy and Per Core Detection Rate of Targeted and Systematic Biopsies Using Real-Time Shear Wave Elastography

et al. 2015

View full text Add to dashboard Cite

Introduction: Prostate cancer (PCa) detection is accompanied by overdiagnosis and mischaracterization of PCa. Therefore, new imaging modalities like shear wave elastography (SWE) are required. Aim: The aim of this study was to evaluate per-core detection rates (DRs) of targeted biopsies and systematic biopsies and to test if SWE findings can predict presence of clinically significant PCa (csPCa) at biopsy. Patients and Methods: Overall, 95 patients scheduled for prostate biopsy in our center underwent SWE. SWE findings were classified into suspicious or normal. Targeted biopsies were taken in up to 3 SWE-suspicious areas. csPCa was defined as the presence of Gleason pattern ≥4, level of prostate-specific antigen ≥10 ng/ml or >2 positive cores. Results: Overall DR for csPCa in our study cohort was 40%. Per-core DR for exclusively SWE-targeted cores versus systematic samples cores was 10.5 vs. 8.6% (p = 0.3). In the logistic regression models, individuals with suspicious SWE findings are at 6.4-fold higher risk of harboring csPCa (p = 0.03). Gain in predictive accuracy was 2.3% (0.82 vs. 0.84, p = 0.01). Conclusions: Presence of suspicious SWE findings is an independent predictor of csPCa. Therefore, SWE may be helpful in selecting patients for biopsy. Nonetheless, per-core DR for SWE-targeted cores was not statistically significant higher than DR of systematic sampled cores. Therefore, additional systematic biopsy is mandatory.

show abstract

“…In the context of this study and aware of the possible limitations of modern ultrasound techniques for PCa diagnosis, the mpMRI analysis of the prostate at 3 Tesla was implemented as an additional tool for visualization of PCa at our institution [9]. Since 2012, every mpMRI TB at our institution has been performed with technical mpMRI/ultrasound fusion guidance rather than cognitive fusion.…”

Section: Discussionmentioning

confidence: 99%

Multiparametric Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Targeted Biopsy of the Prostate: Preliminary Results of a Prospective Single-Centre Study

Junker

Schäfer²,

Heidegger³

et al. 2015

Urol Int

Self Cite

View full text Add to dashboard Cite

Purpose: To evaluate multiparametric magnetic resonance imaging/transrectal ultrasound (mpMRI/TRUS) fusion targeted biopsy (TB) of the prostate for prostate cancer (PCa) diagnosis. Patients and Methods: From April 2013 to January 2014, 53 men were included in this prospective single-centre study. The degree of PCa suspicion from mpMRI findings was classified according to the PI-RADS scoring system. Of these, 50 patients underwent both an mpMRI/TRUS fusion TB and a 10-core systematic biopsy (SB) of the prostate and were eligible for analysis. Results: 225 targeted and 500 systematic cores were included in this study. PCa was histologically confirmed in 52.0% of patients (26/50), whereas TB revealed PCa in 46.0% (23/50) and SB in 36.0% (18/50). TB identified PCa in 16.0% of all patients (8/50) that were missed by SB. All told, the targeted core was 2.8 times more likely to be PCa-positive than the systematic core (29.3 vs. 10.4%). Conclusions: mpMRI/TRUS fusion TB of the prostate is safe, practicable and may improve PCa diagnosis using fewer biopsy cores compared to SB.

show abstract

Comparison of Real-Time Elastography and Multiparametric MRI for Prostate Cancer Detection: A Whole-Mount Step-Section Analysis

Cited by 34 publications

References 26 publications

Impact of Real-Time Elastography on Magnetic Resonance Imaging/Ultrasound Fusion Guided Biopsy in Patients with Prior Negative Prostate Biopsies

Impact of Real-Time Elastography on Magnetic Resonance Imaging/Ultrasound Fusion Guided Biopsy in Patients with Prior Negative Prostate Biopsies

Prediction of Significant Prostate Cancer at Prostate Biopsy and Per Core Detection Rate of Targeted and Systematic Biopsies Using Real-Time Shear Wave Elastography

Multiparametric Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Targeted Biopsy of the Prostate: Preliminary Results of a Prospective Single-Centre Study

Contact Info

Product

Resources

About