Comparison of reactive chromatography and reactive distillation for the synthesis of C1–C4 acetates

Reddy, Bhoja; Bhat, Rahul; Agrawal, Amit; Patidar, Prafull; Mahajani, Sanjay M.

doi:10.1016/j.cep.2015.05.006

Cited by 4 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Distillation, chromatography and membrane separations are the most studied separation processes integrated with reactors to facilitate in-situ product removal for shifting reaction equilibrium in forward direction. Recently Reddy et al [24] compared two multifunctional reactors, reactive distillation and chromatographic reactors, for the production of C1-C4 carboxylic esters. There are several examples of reactive distillation including the celebrated methyl acetate process by Eastman [4].…”

Section: Overcoming Equilibrium Limitations By Combining Reaction Andmentioning

confidence: 99%

Intensifying Multiphase Reactions and Reactors: Strategies and Examples

Utikar

Ranade²

2017

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Intensification is intrinsic to better chemical and process engineering and has always been used in practice. Multiphase reactions and reactors are ubiquitous in chemical and allied industries and are of great economic and ecological importance. There is a great scope for intensifying multiphase reactions and reactors for realizing productivity enhancements, which are crucial for sustainable manufacturing. These enhancements can be in terms of increased throughput; better yield, conversion, and selectivity; smaller environmental footprint; and intrinsically safer operations. The advances in intensified reactors especially micro-reactors and microfluidic devices have created significant awareness about intensification in recent decades. In this note, we discuss different strategies for intensifying multiphase reactions and reactors based on the published information. Variety of tools and examples are presented to showcase the potential of intensification. We have found the efforts towards intensification of multiphase reactions and reactors very rewarding academically as well as professionally. We hope that this note will further stimulate interest in this area and pave the way towards realizing next generation productivity for chemical and allied industries.

show abstract

Section: Overcoming Equilibrium Limitations By Combining Reaction Andmentioning

confidence: 99%

Intensifying Multiphase Reactions and Reactors: Strategies and Examples

Utikar

Ranade²

2017

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…It is crucial to recognize that the performance of SMBR is comparable to that of conventional reactive distillation techniques in several esterification reactions, which asseverates the potential of this technology and makes this proposition worth exploring. 17,18 Even though the process development phases could be identical, the viability of each reacting system depends on its properties, such as reaction kinetics and adsorption behavior. Additionally, it is known that polymerization takes place when the reaction mixture of many esterification reactions is subjected to higher temperatures under low moisture content and acidic conditions for a prolonged period, consequently leading to a loss in product yield.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is essential to broaden the feasibility study of this technology to as many reactions and processes as possible in fine and specialty sectors. It is crucial to recognize that the performance of SMBR is comparable to that of conventional reactive distillation techniques in several esterification reactions, which asseverates the potential of this technology and makes this proposition worth exploring. , …”

Section: Introductionmentioning

confidence: 99%

Transforming Ethyl Chloroacetate Production─Leveraging Reactive Chromatography with Amberlyst-15

Gupta,

Mahajani

2024

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Esterification reactions are the archetype of equilibriumlimited reactions that can be advantageously conducted in multifunctional reactors (e.g., reactive chromatography and reactive distillation) to enhance the per-pass reaction conversion. Ethyl chloroacetate (ECA) is an ester utilized as a precursor in many fine chemical industries, produced by esterification of monochloroacetic acid (MCA) with ethanol (EtOH). This work explores the potential of employing reactive chromatography (RC) for the continuous production of ECA in the presence of ion-exchange resin, Amberlyst-15, as a catalyst and an adsorbent. A fixed-bed chromatographic reactor (FBCR) is used to evaluate the performance of the reaction, wherein Amberlyst-15 plays a dual role of adsorbent for the separation of water and catalyst to expedite the reaction. To mathematically model the system, relevant studies such as batch kinetic experiments at different reaction conditions and thermodynamic adsorption experiments in FBCR were performed to obtain appropriate parameters. This model is further validated with reactive breakthrough and elution profiles in FBCR. The model predicted and experimental results are found to accord reasonably well even for the regenerated catalyst/adsorbent bed. The experimentally validated RC model can be further used to design a simulated moving bed reactor (SMBR), which could prove to be competitive for the continuous production of ECA, if it is designed astutely and optimized well.

show abstract