Comparison of radiolabeled choline and ethanolamine as probe for cancer detection

Mintz, Akiva; Wang, Limin; Ponde, Datta E.

doi:10.4161/cbt.7.5.5746

Cited by 21 publications

(23 citation statements)

References 18 publications

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“…As reported for other matrices, metabolomics studies in PCa also revealed that PCa cells experience alterations in membrane metabolism with changes, for example, in choline metabolite levels (Table 5) [98], [101]. Androgen signaling has an important role in the development and progression of PCa.…”

Section: Altered Metabolism Of Pca Cellsmentioning

confidence: 54%

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Biomarker Discovery in Human Prostate Cancer: an Update in Metabolomics Studies

Lima

Bastos

Carvalho

et al. 2016

Translational Oncology

120

116

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Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on prostate biopsies; however, this approach can lead to false-positive and false-negative results. Therefore, it is important to discover new biomarkers for the diagnosis of PCa, preferably noninvasive ones. Metabolomics is an approach that allows the analysis of the entire metabolic profile of a biological system. As neoplastic cells have a unique metabolic phenotype related to cancer development and progression, the identification of dysfunctional metabolic pathways using metabolomics can be used to discover cancer biomarkers and therapeutic targets. In this study, we review several metabolomics studies performed in prostatic fluid, blood plasma/serum, urine, tissues and immortalized cultured cell lines with the objective of discovering alterations in the metabolic phenotype of PCa and thus discovering new biomarkers for the diagnosis of PCa. Encouraging results using metabolomics have been reported for PCa, with sarcosine being one of the most promising biomarkers identified to date. However, the use of sarcosine as a PCa biomarker in the clinic remains a controversial issue within the scientific community. Beyond sarcosine, other metabolites are considered to be biomarkers for PCa, but they still need clinical validation. Despite the lack of metabolomics biomarkers reaching clinical practice, metabolomics proved to be a powerful tool in the discovery of new biomarkers for PCa detection.

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Section: Altered Metabolism Of Pca Cellsmentioning

confidence: 54%

“…Androgen-nonresponsive cell lines and androgen-responsive cell lines also have differences in their glycolytic metabolism profiles. Androgen-dependent PCa cells and androgen-independent PCa cells also show differences in membrane lipid synthesis (Table 5) [97], [100], [101].…”

Section: Altered Metabolism Of Pca Cellsmentioning

confidence: 99%

Biomarker Discovery in Human Prostate Cancer: an Update in Metabolomics Studies

Lima

Bastos

Carvalho

et al. 2016

Translational Oncology

120

116

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“…ethanolamine labelled with 11 C or 18 F) is a potential new probe in oncology PET-CT imaging for assessment of tumour proliferation [93]. 14 C-ethanolamine has been used in a variety of tumour cell types (i.e.…”

Section: Introductionmentioning

confidence: 99%

Transbilayer phospholipids molecular imaging

Belhocine

Prato

2011

EJNMMI Research

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Nuclear medicine has become a key part of molecular imaging. In the present review article, we focus on the transbilayer phospholipids as exquisite targets for radiolabelled probes in molecular imaging. Asymmetry of phospholipid distribution is a characteristic of mammalian cell membranes. Phosphatidylcholine and sphyngomyelin cholinophospholipids are primarily located within the external leaflet of the cell membrane. Phosphatidylserine and phosphatidylethanolamine aminophospholipids, and also phosphatidylinositol are primarily located within the internal leaflet of the cell membrane. New radiolabelled tracers have been designed in preclinical and clinical research for PET-CT and SPECT-CT molecular imaging of transbilayer phospholipids.

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“…21 However, given the higher abundance of PE in plasma membranes, it was only a matter of time before the uptake of ethanolamine was determined in tumor cells. In the current issue of Cancer Biology and Therapy, Mintz et al 22 evaluate the uptake and retention of ethanolamine, N-N dimethylethanolamine and choline in a variety of tumor cell lines, including prostate and cerebral tumors. The authors show that across the spectrum of cell lines tested, tumor cells concentrated ethanolamine 2 to 7 fold higher than choline when incubated with these tracers.…”

mentioning

confidence: 99%

“…Stimulation of prostate cancer cell proliferation with androgens enhanced uptake of the labeled substrates even further. Given the recent success with 11 C-choline imaging of tumors 20,21 and the results reported by Mintz et al 22 , it is clear that the next step will be in vivo studies with tumor xenografts to directly compare the two radiolabels in a more clinically relevant setting. The half-life of 11 C (20.38 minutes) may limit the availability of radiotracers based on this isotope and the longer path length of the emitted positron compared to that from 18 F can have a negative impact on image resolution.…”

mentioning

confidence: 99%