Comparison of quiet breathing and controlled ventilation in the high-resolution CT assessment of airway disease in infants with cystic fibrosis

Long, Frederick R.; Williams, Roger; Adler, Brent H.; Castile, Robert G.

doi:10.1007/s00247-005-1541-4

Cited by 53 publications

(26 citation statements)

References 16 publications

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“…These gating techniques are already being applied in human studies and will become more prevalent as scanner technology allows visualization of larger and larger volumes of the lung with each acquisition (20). However, even static whole lung images obtained from helical scans during breath-holds at two volumes will yield useful results (7) and provide a unique description of regional lung static mechanical properties that could be applied clinically to quantitate regional lung properties in patients already receiving this type of imaging, such as patients with severe emphysema being considered for lung volume reduction surgery or cystic fibrosis (2,5,17).…”

Section: Discussionmentioning

confidence: 99%

CT-measured regional specific volume change reflects regional ventilation in supine sheep

Fuld¹,

Easley²,

Saba³

et al. 2008

Journal of Applied Physiology

100

105

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Section: Discussionmentioning

confidence: 99%

CT-measured regional specific volume change reflects regional ventilation in supine sheep

Fuld¹,

Easley²,

Saba³

et al. 2008

Journal of Applied Physiology

100

105

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“…The most important variable that requires standardisation during CT scanning is lung volume [26]. Most young children are not able to do a voluntary breath hold at the correct volume level and at the correct moment.…”

Section: Chest Ctmentioning

confidence: 99%

Early intervention studies in infants and preschool children with cystic fibrosis: are we ready?

et al. 2013

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Cystic fibrosis (CF) lung disease starts early in life and progresses even in the absence of clinical symptoms. Therefore, sensitive outcome measures to quantify and track these early abnormalities in infants and young children are needed; both for clinical care and interventional trials. Currently, the efficacy of most therapeutic interventions in CF has not been tested in children under the age of 6 years and drug development programmes have focused on assessing safety rather than efficacy in this age group. This article summarises the current status for outcome measures that can be utilised in clinical trials in infants and children with CF. Two methodologies are specifically highlighted in this review; chest computed tomography to assess structural damage of the lung and multiple breath washout as a technique to quantify ventilation inhomogeneity. While not all questions regarding the utility of these outcome measures in infants and young children have been resolved, significant advances have been made and it now appears feasible to design and conduct adequately powered efficacy studies in this age group. This could be a crucial step to further improve outcomes in CF patients as initiating effective treatment early is considered essential to prevent permanent lung damage. @ERSpublications Crucial to CF outcome is early effective treatment, hence intervention studies in infants and preschool children are a must

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“…In a study of infants with ''new'' nCLD, MAHUT et al [33] reported a dissociation between airway function, as measured by maximal flow at function residual capacity, and computed tomographic abnormalities, suggesting a decreased airway involvement in the pathology of ''new'' nCLD. Studies combining new lung imaging approaches in young children [34] and lung function methods sensitive to peripheral mechanics, such as FOT, are required to address these issues in detail. In particular, techniques capable of determining alveolar surface area in vivo are likely to be informative.…”

Section: Resistance and Reactancementioning

confidence: 99%

Forced oscillations in the clinical setting in young children with neonatal lung disease

Udomittipong

Sly²,

Patterson³

et al. 2008

European Respiratory Journal

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The extent of respiratory dysfunction is not well characterised in children with neonatal chronic lung disease (nCLD) too young to perform spirometry. Forced oscillations are easily performed by healthy young children; however, they may be more difficult for those with nCLD. The present study aimed to describe the feasibility of using the forced oscillation technique in children with nCLD in a routine clinical setting and to investigate the influence of neonatal factors on subsequent lung function.Respiratory function tests were attempted in 64 patients with nCLD aged 3.2-6.6 yrs. Respiratory resistance and reactance at 6, 8 and 10 Hz were expressed as z-scores derived from a healthy reference population. The within-test variation and between-test repeatability were also assessed.Technically, satisfactory data were obtained from 77% of children. On grouped data, z-scores for all oscillatory indices were different from zero and related to hospital oxygen administration in the neonatal period.In conclusion, the forced oscillation technique was feasible in preschool children with neonatal chronic lung disease in the clinical outpatient setting. These children had lung function significantly worse than that predicted from healthy children. Respiratory function assessed using forced oscillations appeared to reflect the severity of lung disease during the neonatal period.

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Comparison of quiet breathing and controlled ventilation in the high-resolution CT assessment of airway disease in infants with cystic fibrosis

Abstract: In infants with CF, fully inflating the lung improved the ability to diagnose early BE, and obtaining motion-free images at end exhalation enhanced the detection of AT.

Cited by 53 publications

References 16 publications

CT-measured regional specific volume change reflects regional ventilation in supine sheep

CT-measured regional specific volume change reflects regional ventilation in supine sheep

Early intervention studies in infants and preschool children with cystic fibrosis: are we ready?

Forced oscillations in the clinical setting in young children with neonatal lung disease

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