Comparison of Quality of Life in Advanced Laryngeal Cancer Patients after Concurrent Chemoradiotherapy vs Total Laryngectomy

Trivedi, Nirav; Swaminathan, Dhanya Kalathungal; Thankappan, Krishnakumar; Chatni, Shilpa; Kuriakose, Moni Abraham; Iyer, Subramania

doi:10.1016/j.otohns.2008.06.002

Cited by 51 publications

(70 citation statements)

References 26 publications

(4 reference statements)

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“…Tivedi et al found no difference in global QOL between surgery and chemoradiotherapy for treatment of advanced laryngeal cancers. 20 Xerostomia was significantly worse in the chemoradiotherapy group but surgically treated patients reported more difficulty with communication.…”

Section: Discussionmentioning

confidence: 87%

Quality of life after treatment of laryngeal carcinoma: a single centre cross-sectional study

Williamson

Ingrams

Jones

2011

annals

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The mainstays of treatment for head and neck cancers include surgery, chemotherapy and radiotherapy given alone or in combination. However, the side effects of these treatments are multifactorial in nature, causing substantial physical as well as psychosocial morbidity.1,2 Their location inherently affects life's basic and vital functions including breathing, feeding and oral communication. Furthermore, altered appearance, difficulty in swallowing and pain as a result of treatment can cause problems with social function and have a further effect on a patient's quality of life (QOL). 3A number of studies have revealed QOL is affected by T and N stage, 4,5 time after treatment and treatment modality. [5][6][7] Investigation into the effect of these factors on specific aspects of QOL such as saliva production and swallowing has yielded varying conclusions. 7-10The aim of this study was to identify whether factors including patient age, treatment modality, tumour stage and nodal status significantly affect quality of life in patients treated for laryngeal cancer. It was hypothesised that patients with advanced T stage and nodal disease would experience poorer QOL. Furthermore, patients undergoing surgical treatment with or without chemoradiotherapy would experience poorer QOL than those undergoing primary radiotherapy.We aimed to identify those aspects of QOL that are significantly affected in order to counsel patients regarding the significant risks and benefits of treatment with uncertain curative outcomes. Furthermore, we aimed to identify patients at risk of significant side effects before treatment in order to effectively prepare them for their treatment experience and focus support from health professionals on the appropriate patients. MethodsThe University of Washington Quality of Life (UW-QOL) questionnaire is a validated tool for determining QOL outcomes in patients treated for head and neck cancer.9,11,12 We used version 3 of the questionnaire (the most current at the time), which consists of ten domain specific questions that ask patients regarding their experiences of pain, appearance, activity level, recreation, swallowing, chewing, speech, shoulder function, taste and saliva production in the last seven days, compared to the month before they de- . We aimed to identify which aspects of QOL and which patients are most affected by the various treatment options. METHODS The University of Washington Quality of Life (UW-QOL) questionnaire was administered to all patients with laryngeal cancer treated at a single institution over a seven-year period (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010). RESULTS In total, 41 patients responded. All had been treated for squamous cell carcinoma of the larynx. Questionnaires were completed at a median of 18.5 months after treatment. The overall quality of life was 81.1/100 as assessed by the UW-QOL scale, with only 4.9% reporting 'poor' or worse QOL. Neither patient age nor time after treatment significantly affected any aspect of QOL. Patients undergoing primary r...

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Section: Discussionmentioning

confidence: 87%

Quality of life after treatment of laryngeal carcinoma: a single centre cross-sectional study

Williamson

Ingrams

Jones

2011

annals

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“…The TAs along with the malignancy itself affect the QOL [16][17][18]. Since TA is a distressing side effect of chemotherapy and can greatly affect the nutrition of the patients, great care must be taken from the initiation of the therapy to prevent the progression of the distress.…”

Section: Resultsmentioning

confidence: 99%

Taste Alteration and Quality of Life of Patients Receiving Chemotherapy

Antony

Pavithran

2017

Asian J Pharm Clin Res

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Objective: The study was conducted with the aim to determine the taste alteration (TA) and its relation with quality of life (QOL) of patients receiving chemotherapy. Methods:The present study was undertaken among 100 patients receiving cancer chemotherapy with the aim of identifying the commonly experienced TA and its relation with QOL of the patients. The patients were selected by convenience sampling from a selected Cancer Institute in Kerala.Results: The study reported that TA was present in all the patients receiving chemotherapy ranging from mild to severe where 50% had moderate and 9% had severe alteration in taste. There were 19% patients who had poor and 45% who had average QOL. The TAs had a moderately negative correlation with QOL (r=−0.51) indicating that an increase in TA decreases the QOL. Conclusion:The study evinces that TA is a common side effect of chemotherapy which often impacts the QOL negatively. Hence, it is essential to understand the types of TA and the specific drug causing it. This will enable the health-care team members to develop treatments for these conditions and educate patients regarding the strategies to be adopted to manage the problem, thereby improving patients' QOL.

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“…A literatura apresenta vários estudos que visam avaliar a QV de pessoas com câncer de cabeça e pescoço por meio da utilização de questionários específicos (LIST et al, 1996;LOTEMPIO et al, 2005;FURIA 2005;SCHINDLER et al, 2006;AARSTAD et al, 2006; Discussão 57 ___________________________________________________________________________ DORNFELD et al, 2007;VAN DER SCHROEFF et al, 2007;DONATELLI-LASSIG et al, 2008;THOMAS et al, 2008;TRIVEDI et al, 2008) permitindo avaliar a qualidade de vida tanto na fase do pré, quanto no pós tratamento da doença.…”

Section: Avaliação Da Qualidade De Vida Relacionada à Saúdeunclassified

“…No presente estudo, a QVRS dos sujeitos com câncer de cabeça e pescoço foi avaliada pelo instrumento FACT-H&N em consonância com estudos encontrados na literatura (FURIA 2006;TRIVEDI et al, 2008;LIST et al, 1996). Este instrumento foi escolhido por ser (por exemplo, cerveja, vinho, etc.…”

Section: Avaliação Da Qualidade De Vida Relacionada à Saúdeunclassified

“…Os resultados do FACT-H&N mostraram de maneira geral, que as pessoas de ambos os grupos (G1 e G2) avaliaram como satisfatória sua qualidade de vida global, o que se assemelha ao estudo realizado por Trivedi et al (2008), que buscou investigar a QV de pessoas laringectomizadas totais comparados com as tratadas apenas com radioquimioterapia.…”

Section: Avaliação Da Qualidade De Vida Relacionada à Saúdeunclassified

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Qualidade de vida relacionada à saúde e uso de tecnologia de comunicação alternativa por pessoas com câncer de cabeça e pescoço

Gomes¹

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Comparison of Quality of Life in Advanced Laryngeal Cancer Patients after Concurrent Chemoradiotherapy vs Total Laryngectomy

Abstract: Long-term overall QOL remains similar in all the patients treated for advanced carcinoma of the larynx irrespective of treatment modality.

Cited by 51 publications

References 26 publications

Quality of life after treatment of laryngeal carcinoma: a single centre cross-sectional study

Quality of life after treatment of laryngeal carcinoma: a single centre cross-sectional study

Taste Alteration and Quality of Life of Patients Receiving Chemotherapy

Qualidade de vida relacionada à saúde e uso de tecnologia de comunicação alternativa por pessoas com câncer de cabeça e pescoço

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