Comparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: Examining evidence for the schizo-obsessive subtype

Docherty, Anna R.; Coleman, Michael J.; Tu, Xiawei; Deutsch, Curtis K.; Mendell, Nancy R.; Levy, Deborah L.

doi:10.1016/j.schres.2012.06.033

Cited by 9 publications

(8 citation statements)

References 26 publications

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“…In a robust sample of schizo-obsessive patients, eye tracking dysfunction was found to be elevated compared to schizophrenia and OCD patients in contrast to other traits such as craniofacial dysmorphology and thought disorder, which were not shown to be altered. 117 This study, however, did not include unaffected relatives; thus, any conclusions about intermediate phenotypes are limited.…”

Section: Schizo-obsessive Disordermentioning

confidence: 98%

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Schizo-obsessive spectrum disorders: an update

Scotti-Muzzi

Saide

2016

CNS Spectr.

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The presence of obsessive-compulsive symptoms (OCS) and obsessive-compulsive disorders (OCD) in schizophrenia is frequent, and a new clinical entity has been proposed for those who show the dual diagnosis: the schizo-obsessive disorder. This review scrutinizes the literature across the main academic databases, and provides an update on different aspects of schizo-obsessive spectrum disorders, which include schizophrenia, schizotypal personality disorder (SPD) with OCD, OCD with poor insight, schizophrenia with OCS, and schizophrenia with OCD (schizo-obsessive disorder). An epidemiological discussion on the discrepancies observed in the prevalence of OCS and OCD in schizophrenia across time is provided, followed by an overview of the main clinical and phenomenological features of the disorder in comparison to the primary conditions under a spectral perspective. An updated and comparative analysis of the main genetic, neurobiological, neurocognitive, and pharmacological treatment aspects for the schizo-obsessive spectrum is provided, and a discussion on endophenotypic markers is introduced in order to better understand its substrate. There is sufficient evidence in the literature to demonstrate the clinical relevance of the schizo-obsessive spectrum, although little is known about the neurobiology, genetics, and neurocognitive aspects of these groups. The pharmacological treatment of these patients is still challenging, and efforts to search for possible specific endophenotypic markers would open new avenues in the knowledge of schizo-obsessive spectrum.

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Section: Schizo-obsessive Disordermentioning

confidence: 98%

“…Within the schizo-obsessive spectrum, intermediate phenotype studies may help to identify its underlying pathophysiology, and eventually, they may have an impact over nosological classifications and treatment outcome. 117…”

Section: Endophenotypic Markersmentioning

confidence: 99%

Schizo-obsessive spectrum disorders: an update

Scotti-Muzzi

Saide

2016

CNS Spectr.

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“…There is a long-lasting debate about the validity of considering a subtype of schizo-obsessive patients in the schizophrenia spectrum. 26 , 27 , 30 , 31 Schizo-obsessive patients seem to have distinct clinical features, such as higher global, positive and negative symptom severity, more suicide attempts, earlier age at onset or specific cognitive deficits. 26 , 32 According to Poyurovsky et al , 26 delineation of distinct subgroups of patients on a putative schizophrenia–OCD axis has prognostic and treatment implications, as first-line medications for one disorder can exacerbate the symptoms of the other.…”

Section: Discussionmentioning

confidence: 99%

Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia

et al. 2016

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Common single-nucleotide polymorphisms (SNPs) account for a large proportion of the heritability of obsessive-compulsive disorder (OCD). Co-ocurrence of OCD and schizophrenia is commoner than expected based on their respective prevalences, complicating the clinical management of patients. This study addresses two main objectives: to identify particular genes associated with OCD by SNP-based and gene-based tests; and to test the existence of a polygenic risk shared with schizophrenia. The primary analysis was an exon-focused genome-wide association study of 370 OCD cases and 443 controls from Spain. A polygenic risk model based on the Psychiatric Genetics Consortium schizophrenia data set (PGC-SCZ2) was tested in our OCD data. A polygenic risk model based on our OCD data was tested on previous data of schizophrenia from our group. The most significant association at the gene-based test was found at DNM3 (P=7.9 × 10−5), a gene involved in synaptic vesicle endocytosis. The polygenic risk model from PGC-SCZ2 data was strongly associated with disease status in our OCD sample, reaching its most significant value after removal of the major histocompatibility complex region (lowest P=2.3 × 10−6, explaining 3.7% of the variance). The shared polygenic risk was confirmed in our schizophrenia data. In conclusion, DNM3 may be involved in risk to OCD. The shared polygenic risk between schizophrenia and OCD may be partially responsible for the frequent comorbidity of both disorders, explaining epidemiological data on cross-disorder risk. This common etiology may have clinical implications.

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“…Also the results of some other studies revealed that negative symptoms in schizophrenia with OCS are lower than those without such symptoms i.e., lower scores of flat affect subscale from the scale for the assessment of negative symptoms (SANS) in schizoobsessive subgroup (Lysaker et al, 2004;Poyurovsky et al, 1999). At the end, there is also evidence that no significant difference exists between schizophrenia with and without OCS in terms of positive/negative symptoms, clinical manifestations, and prognosis (Byerly et al, 2005;Poyurovsky et al, 2001;Poyurovsky et al, 2006;Faragian et al, 2009;Docherty et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Obsessive-Compulsive Symptoms in Schizophrenia

Nasrollahi

Abasi

Mohammadi

et al. 2016

PCP

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The relationship between obsessive compulsive disorder and schizophrenia has been a matter of dispute for ages. This study aimed to investigate the differences between schizophrenia with obsessive-compulsive symptoms (OCS) and schizophrenia without OCS in positive and negative symptoms of schizophrenia. Methods: Study participants comprised 30 patients with schizophrenia with OCS and 30 patients with schizophrenia without OCS which were enrolled through convenience sampling method from Roozbeh Hospital, Tehran, Iran. Diagnosis was made by a psychiatrist using SCID-I and the data were gathered using positive and negative syndrome scale (PANSS) and Yale-Brown obsessive-compulsive scale (Y-BOC). MANCOVA test was used for analyzing data. Results: Results indicated that there was not any difference between schizophrenia with OCS group and schizophrenia without OCS group with regard to positive symptoms, but the difference in negative symptoms between two groups was significant. Conclusion: The present study reveals that OCS may be a protective factor for schizophrenia. Further studies are needed to investigate other factors and mediators involved in this association.

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Comparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: Examining evidence for the schizo-obsessive subtype

Cited by 9 publications

References 26 publications

Schizo-obsessive spectrum disorders: an update

Schizo-obsessive spectrum disorders: an update

Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia

Protective Role of Obsessive-Compulsive Symptoms in Schizophrenia

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