Comparison of pulp response to mineral trioxide aggregate and a bioceramic paste in partial pulpotomy of sound human premolars: a randomized controlled trial

Abstract

When treating teeth with healthy pulps, the response to partial pulpotomy treatment with both MTA and iRoot BP was favourable. However, pulps covered with iRoot BP were more sensitive to cold stimuli.

Effects of iRoot BP and white mineral trioxide aggregate on cell viability and the expression of genes associated with mineralization

“…, Azimi et al . ). Although the results varied according to dilution and time period, they revealed a similar cell viability of iRoot BP compared to WMTA.…”

“…This study evaluated the cytotoxicity and effects of iRoot BP and WMTA on the expression of mineralization-related genes. The in vitro cytotoxicity of the materials was evaluated by XTT assay, a standard assay of cytotoxicity and cell survival (Koulaouzidou et al 2008, De-Deus et al 2009, Damas et al 2011, Azimi et al 2014. Although the results varied according to dilution and time period, they revealed a similar cell viability of iRoot BP compared to WMTA.…”

“…In vitro studies have reported no significant difference between iRoot BP and MTA in terms of antimicrobial efficacy, pulp inflammation or formation of hard tissue bridges (Azimi et al . , Damlar et al . ).…”

“…Due to its calcium silicate composition, it requires the presence of moisture to set. In vitro studies have reported no significant difference between iRoot BP and MTA in terms of antimicrobial efficacy, pulp inflammation or formation of hard tissue bridges (Azimi et al 2014, Damlar et al 2014.…”

Biocompatibility and biomineralization assessment of bioceramic-, epoxy-, and calcium hydroxide-based sealers

“…Studies involving other bioceramic endodontic sealers already revealed hard tissue deposition 29 and favorable tissue response to partial pulpotomy. 30 Monobasic calcium phosphates are included in the sealer to facilitate the reaction with calcium hydroxide to produce water and hydroxyapatite upon activation of the sealer by water. 31 Previous studies on bioceramic sealers have revealed lower inflammatory mediators and better osteoblast expression, thus indicating that the bioceramic is biocompatible.…”