“…In fact, if one were to take a large population of patients and gather an aggregate of filling pressures, the low CVP and PaOP would likely predict volume responsiveness among this large group; however, when caring for the individual patient, these filling pressures do not predict with enough accuracy or reliability that a low value translates to volume responsiveness. Not only are the absolute values of CVP and PaOP poor surrogates for volume responsiveness, but also several studies have shown that changes in CVP and PaOP after a fluid challenge do not correlate with changes in CO (9,13,15,16). Kumar et al (13) demonstrated this concept definitively in a study of healthy volunteers.…”