Comparison of Propofol-Ketamine Combination with Propofol-Butorphanol Combination for Total Intravenous Anaesthesia on Short Surgical Procedures

Regmi, Nabin Kumar; Khatri, Santosh; Datta, Prashanta Kumar

doi:10.3126/jngmc.v12i2.14474

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Rao et al (2013), [22] used Butorphanol 40µg/kg & Fentanyl 2µg/kg and for induction thiopentone 5mg/kg. Regmi et al (2014), [23] used Butorphanol 20µg/kg and induction was done by 1.5mg/kg Propofol. We used Butorphanol 20µg/kg I.V.…”

Section: Resultsmentioning

confidence: 99%

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Comparison of Propofol with Butorphanoland Propofol with Fentanyl for Total Intravenous Anaesthesia in Short Surgical Procedures

Trivedi¹,

Resident²,

Patel³

et al. 2019

AAN

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Background: Total intravenous anaesthesia is a technique in which induction and maintenance of anaesthesia is achieved with intravenous drug alone. With analgesics complete anaesthesia can be achieved. Objectives: To study & compare the hemodynamic profile, intra operative analgesic adequacy, VAS score and emergence time between two groups. Subjects and Methods: Total 80 patients of ASA grade I & II, aged 18-60years old, who were posted for short surgical procedures were randomly divided into two groups. Group I received Inj.Butorphanol 20μg/kg and Group II received Inj.Fentanyl 2μg/kg body weight. Both the groups received Inj. Propofol 2mg/kg I.V. and then maintenance of anaesthesia started with Propofol as a stepped down scheme. Intra operative depth of anaesthesia was monitored using clinical signs like rise in blood pressure, pulse and respiratory rate. Post-operative sedation score was noted using Ramsay Sedation score. Visual analogue score for pain, was noted at the time of emergence time. Results: Respiratory rate, heart rate and SpO2 showed no significant differences between groups. Average systolic and diastolic BP in group I was lower as compared to group II during the surgery and post-operative at the time of emergence also. Mean emergence time in group I was significantly higher than group II. Mean VAS at the time of emergence was significant less in butorphanol group. Conclusion: From the present study it can be concluded that, Butorphanol & Fentanyl combined with Propofol are comparable in hemodynamic profile. Post-operative more time is taken for emergence in Butorphanol group. VAS score for pain at the time of emergence is more in Fentanyl group compared to Butorphanol. With conventional monitoring, depth of anaesthesia is satisfactory between groups. With both the drugs satisfactory anaesthesia can be provided for short surgical procedures which are 30 or less in duration.

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Section: Resultsmentioning

confidence: 99%

“…2014) did study in patients undergoing elective short surgical procedure less than 60 minutes. [23] Figure 1: Line diagram showing average heart rate in both the groups.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Propofol with Butorphanoland Propofol with Fentanyl for Total Intravenous Anaesthesia in Short Surgical Procedures

Trivedi¹,

Resident²,

Patel³

et al. 2019

AAN

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Comparison of Propofol-Fentanyl Versus Propofol-Ketamine Combination as Total Intravenous Anesthesia in Maxillofacial Surgical Procedures – A Prospective Randomized Controlled Study

Tusharbhai

Baliga

Kamath

et al. 2022

Biomed. Pharmacol. J.

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Background: Total intravenous anesthesia (TIVA) is a technique where drugs are administered intravenously for the induction and maintenance of anesthesia instead of volatile drugs, avoiding some of the drawbacks of inhalation anesthesia providing rapid and complete recovery making it suitable for daycare surgeries. Aim: To compare the intraoperative and postoperative hemodynamic patterns, postoperative recovery time, and unwanted consequences such as post-operative nausea and vomiting (PONV) in various maxillofacial procedures using a combination of two drug regimens, namely propofol-ketamine and propofol-fentanyl. Patient & methods: 40 patients between the age group of 18-40 years of either gender were randomly divided into two groups with propofol-ketamine (group 1, n=20) and propofol-fentanyl (group 2, n=20) who underwent various surgical procedures like cyst enucleation, open reduction and internal fixation (ORIF) of facial fractures, orthognathic procedures such as maxillary or mandibular segmental osteotomy and genioplasty with the procedure lasting 60 to 75 minutes. This study compared the total amount of propofol, time of the infusion, and hemodynamic parameters like mean pulse rate (PR), oxygen saturation level (SpO2), systolic blood pressure (SBP) & diastolic blood pressure (DBP), emergence time & recovery time, undesirable sequels like postoperative nausea and vomiting (PONV) and any other side effects between both the groups. Results were analyzed statistically using an independent t-test and chi-square test. Results: A comparison of two groups revealed a significant rise in systolic blood pressure in group 1 as compared to group 2 and group 2 showed better emergence time & recovery time with fewer incidences of postoperative nausea and vomiting and other side effects. Conclusion: Since the propofol-fentanyl provided significantly good results it can be considered as an alternative to gaseous anesthetic agents in various maxillofacial surgical procedures mentioned in the materials with the surgical procedure lasting 60-75 minutes.

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Comparison of Propofol-Ketamine Combination with Propofol-Butorphanol Combination for Total Intravenous Anaesthesia on Short Surgical Procedures

Cited by 2 publications

References 8 publications

Comparison of Propofol with Butorphanoland Propofol with Fentanyl for Total Intravenous Anaesthesia in Short Surgical Procedures

Comparison of Propofol with Butorphanoland Propofol with Fentanyl for Total Intravenous Anaesthesia in Short Surgical Procedures

Comparison of Propofol-Fentanyl Versus Propofol-Ketamine Combination as Total Intravenous Anesthesia in Maxillofacial Surgical Procedures – A Prospective Randomized Controlled Study

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