Comparison of progesterone measurement on day of, and day after, HCG administration in IVF–embryo transfer cycles

Liu, Liu; Zhao, Lijuan; Li, Tin‐Chiu; Zhu, Haiyan; Lin, Xiaona; Jin, Xiaoying

doi:10.1016/j.rbmo.2014.10.017

Cited by 16 publications

(14 citation statements)

References 21 publications

(39 reference statements)

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“…Several previous studies (Al-Azemi et al, 2012;Bosch et al, 2010;Huang et al, 2012;Lahoud et al, 2012;Ochsenkühn et al, 2012;Papanikolaou et al, 2012;Wu et al, 2012;Xu et al, 2012) and one recent meta-analysis (Venetis et al, 2013) suggest that elevated progesterone on the day of human chorionic gonadotropin (HCG) (PHCG) administration was associated with adverse pregnancy outcomes in women undergoing IVF and embryo transfer treatment. Our recent study (Liu et al, 2014) confirmed previous observations, and more importantly, we found that elevated progesterone on the day after HCG administration (PHCG+1) was also associated with a decreased pregnancy rate. Our findings were consistent with a recent report in unstimulated cycles, which showed that the progesterone elevation for 2 days or more before the LH surge impaired the clinical pregnancy rate of frozen-thawed embryo transfers in natural cycles, whereas progesterone elevation only on the day of LH surge did not have such an adverse effect, suggesting that serial progesterone measurements around the time of LH surge or HCG administration is more informative than a single measurement (Lee et al, 2014).…”

Section: Introductionsupporting

confidence: 92%

“…According to our recently published study (Liu et al, 2014), the 90% percentile of progesterone level before oocyte retrieval derived from the data consisting of a total of 1457 fresh embryo transfers between 2011and 2013 in our hospital was used as the cut-off to define high progesterone level, which was 1.7 ng/ml on the day of HCG administration (PHCG) and 9.5 ng/ml on the day after HCG administration (PHCG+1).…”

Section: Definition Of High Progesteronementioning

confidence: 99%

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The effect of a high progesterone concentration before oocyte retrieval on the peri-implantation endometrium

Liu

Sailan

et al. 2015

Reproductive BioMedicine Online

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In this single-centre, prospective cohort study, the effect of high progesterone level before oocyte retrieval on endometrial morphology and uterine natural killer cell (uKN) count in the peri-implantation period was investigated. A total of 106 women undergoing IVF treatment who did not proceed to fresh embryo transfer were included. Endometrial samples were obtained 7 days after HCG administration. Multiple regression analysis was used to identify factors affecting the results of histological staging and uNK cell count. Progesterone level on the day after HCG administration was the only significant variable associated with the results of histological staging (P = 0.004). Endometrial development in women with high progesterone level was significantly (P < 0.001) more advanced than that of women with normal progesterone; progesterone level on the day of HCG administration was the only significant variable associated with uNK cell count. The median (range) of uNK cell count of 9.6% (2.3-21.6%) in women with high progesterone was significantly (P < 0.001) higher than the median (range) of uNK cell count of 5.7% (1.4-18.7%) in women with normal progesterone. High progesterone level before oocyte retrieval was correlated with advancement in endometrial development as well as increased uNK cell count.

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Section: Introductionsupporting

confidence: 92%

Section: Definition Of High Progesteronementioning

confidence: 99%

The effect of a high progesterone concentration before oocyte retrieval on the peri-implantation endometrium

Liu

Sailan

et al. 2015

Reproductive BioMedicine Online

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“…Investigators continue to seek for more sensitive and specific tests to predict cycle outcome and optimize treatment of couples undergoing IVF-ICSI and embryo transfer. In relation to this, the associations of elevated P-values and P-valuesoestradiol ratio on day of, or day after, HCG administration with cycle outcomes have been extensively investigated (Keltz et al, 2012;Liu et al, 2015;Santos-Ribeiro et al, 2014;Sonntag et al, 2013), whereas the relationship of HCG value after trigger and cycle outcomes was seldomly studied.…”

Section: Discussionmentioning

confidence: 99%

The value of HCG serum concentrations after trigger in predicting pregnancy and live birth rates in IVF–ICSI

Zhou¹,

Wang²,

Wang

et al. 2015

Reproductive BioMedicine Online

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The aim of this study was to determine if an association existed between serum human chorionic gonadotrophin (HCG) level at 12 h after trigger and IVF and intracytoplasmic sperm (ICSI) treatment outcomes. Women undergoing initial IVF-ICSI and embryo transfer treatment using the long luteal phase gonadotrophin-releasing hormone agonist protocol between April 2012 and March 2013 for tubal factor were included (n = 699). In the clinical pregnancy group, HCG after trigger was significantly elevated (276.0 ± 5.1 versus 198.5 ± 6.1 mIU/mL; P < 0.001). The optimal cut-off value proposed by the receiver operating characteristic analysis (area under curve = 0.730) for HCG was 201.2 mIU/ml. Compared with the lower HCG group, the clinical pregnancy rate in the higher HCG group was increased in obese and non-obese patients (77.8% versus 57.3%, P < 0.05; 85.6% versus 53.0%, P < 0.01, respectively). Adjusted for age and body mass index, an increase of HCG was associated with a better IVF-ICSI treatment outcome (OR 4.39, 95% CI 2.99 to 6.45). Clinical pregnancy rate was significantly higher across increasing quartiles of HCG. An elevated level of serum HCG at 12 h after trigger was associated with a better IVF-ICSI outcome.

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“…Previous study analyzed the additive value of progesterone level determination 24 hours after recombinant-HCG administration and revealed an improved predictive value compared with a single measurement on the day of recombinant-HCG administration, the authors concluded that the high progesterone levels on both days resulted in low implantation rates compared with normal levels in IVF/ICSI cycles (22% vs. 36%) ( 17 ) . There is also some evidence that basal progesterone levels may be used to predict premature progesterone elevation in IVF/ICSI cycles ( 18 ) .…”

Section: Discussionmentioning

confidence: 99%

The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles

Kutlu

Özkaya

Sanverdi

et al. 2016

tjod

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Objective:To assess the relationship between the estrogen-progesterone alterations before and after ovulation trigger and treatment success in intrauterine insemination (IUI) cycles.Materials and Methods:Two hundred fifty-one women with infertility underwent ovulation induction followed by IUI. For all subjects, estradiol and progesterone concentrations were evaluated on the trigger and IUI day. The results were analyzed to assess the relationship between hormone levels and positive pregnancy test.Results:There were 34 women with a positive pregnancy test following controlled ovarian stimulation and IUI cycle. Estradiol and progesterone levels on the trigger day and the day of IUI were compared within groups with and without positive pregnancy tests. The comparison revealed significantly increased levels of progesterone after trigger in both groups; however, although there were estradiol level drops in both groups, the drop in the group with negative pregnancy tests was statistically significant.Conclusion:Significant drops in estradiol concentrations after ovulation trigger are associated with IUI cycle treatment failure.

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Comparison of progesterone measurement on day of, and day after, HCG administration in IVF–embryo transfer cycles

Cited by 16 publications

References 21 publications

The effect of a high progesterone concentration before oocyte retrieval on the peri-implantation endometrium

The effect of a high progesterone concentration before oocyte retrieval on the peri-implantation endometrium

The value of HCG serum concentrations after trigger in predicting pregnancy and live birth rates in IVF–ICSI

The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles

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