Comparison of preoperative neutrophil–lymphocyte, lymphocyte–monocyte, and platelet–lymphocyte ratios in patients with upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy

Abstract

PurposeThe aim of this study was to investigate the prognostic value of preoperative neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and lymphocyte–monocyte ratio (LMR) in patients with upper urinary tract urothelial carcinoma (UUTUC).MethodsWe retrospectively analyzed the clinical data of 140 patients with UUTUC who underwent radical nephroureterectomy from January 2005 to December 2011. We plotted receiver operating characteristic curves of NLR, PLR, and LMR for the diagnosis of tumor recurrence. Survival analysis was performed using the Kaplan–Meier method and log-rank test. Independent risk factor analysis was performed using a Cox proportional hazards regression model.ResultsReceiver operating characteristic curves showed that NLR was superior to PLR and LMR as a predictive factor in patients with UUTUC undergoing radical nephroureterectomy. Univariate analysis revealed that NLR (P<0.001 and P<0.001), PLR (P=0.01 and P<0.001), and LMR (P<0.001 and P<0.001) were significantly associated with disease-free survival and progression-free survival (PFS), respectively. Multivariate analysis identified NLR and LMR as independent prognostic factors for disease-free survival (P=0.035 and P=0.002) and PFS (P=0.005 and P=0.002), respectively.ConclusionNLR and LMR could be independent predictors of disease-free survival and PFS, and NLR is a superior predictive factor to LMR.

Prognostic significance of platelet–lymphocyte ratio in patients receiving first-line tyrosine kinase inhibitors for metastatic renal cell cancer

“…Recently, several biomarkers and hematological indices representative of systemic inflammatory responses, including the neutrophil–lymphocyte ratio (NLR), the platelet–lymphocyte ratio (PLR), and the combination of the C-reactive protein (CRP) and albumin known as the Glasgow prognostic score (GPS) were introduced as prognostic factors in various cancers. For example, the NLR and PLR have been suggested as prognostic indicators for lung, colorectal, breast, gastric and pancreatic cancer, as well as urinary cancers such as RCC, and urothelial carcinoma (Feng et al 2014; Raungkaewmanee et al 2012; Hu et al 2015; Song et al 2016; Nakano et al 2014). Templeton et al (2014a, b) investigated the prognostic role of NLR and PLR in solid tumors.…”

Predictive role of neutrophil-to-lymphocyte ratio on upstaging of organ-confined invasive urothelial bladder cancer to non-organconfined disease

“…Some novel inflammatory indicators can be established by combining peripheral blood cell counts, such as NLR, PLR, and LMR, which have been investigated for their predictive prognostic values in malignant tumors. [12] Based on the numbers of circulating inflammatory cells, some indexes have been calculated and used as valuable prognostic predictors. [12] In this study, our purpose is to determine the predictive value of preoperative inflammatory markers for upstaging of bladder cancer in patients who underwent RC.…”

“…[12] Based on the numbers of circulating inflammatory cells, some indexes have been calculated and used as valuable prognostic predictors. [12] In this study, our purpose is to determine the predictive value of preoperative inflammatory markers for upstaging of bladder cancer in patients who underwent RC.…”

“…[9,10] But precystectomy parameters which are used for extravesical upstaging at the time of RC are not very reliable and sufficient to guide clinical decision making process. [11,12] For this reason, other reliable pretreatment prognostic factors are urgently needed. [12] Cancer-related inflammation is the seventh hallmark of cancer, with inflammatory cells and mediators being an essential component of the tumor micro-environment.…”

“…[11,12] For this reason, other reliable pretreatment prognostic factors are urgently needed. [12] Cancer-related inflammation is the seventh hallmark of cancer, with inflammatory cells and mediators being an essential component of the tumor micro-environment. [13] Changes in host inflammatory responses and tumor relations have been increasingly recognized in various tumor types and inflammatory cells around the tumor cells play a significant role in the progress and prognosis of tumors.…”