Comparison of Preoperative Inflammation-based Prognostic Scores in Patients With Colorectal Cancer

Suzuki, Yoshiyuki; Okabayashi, Koji; Hasegawa, Hirotoshi; Tsuruta, Masashi; Shigeta, Kohei; Kondo, Takayuki; Kitagawa, Yuko

doi:10.1097/sla.0000000000002115

Cited by 110 publications

(117 citation statements)

References 24 publications

Supporting

Mentioning

108

Contrasting

Order By: Relevance

“…Most frequently evaluated prognostic factors include those directly associated to the neoplasm per se, that is, morphologic, proteomic, genomic or epigenomic, while the patient's immune and nutritional status have been often overlooked . There is an increasing evidence that systemic inflammation plays a critical role in carcinogenesis and the invasion or metastatic processes in CRC . The tumor‐associated inflammatory response has been recognized to exert a contradictory effect, enhancing tumorigenesis and progression, and actually aiding incipient neoplasms to acquire hallmark capabilities .…”

Section: Discussionmentioning

confidence: 99%

Association of the prognostic nutritional index and overall survival in patients with colorectal cancer: A STROBE compliant retrospective cohort study

et al. 2019

View full text Add to dashboard Cite

Background The TNM classification does not completely reflect the prognosis of patients with colorectal cancer (CRC). Several clinical factors have been used to increase its prognostic value, but factors pertaining to the patient's immunonutritional status have not usually been addressed. The aim of this study is to evaluate the role of Prognostic nutritional index (PNI) and other well‐known prognostic factors by multivariate analysis in a cohort of patients with CRC. Methods This is a retrospective cohort study of consecutive patients with CRC managed in a cancer center between January 1992 and December 2016. Cox's model was used to define the association of the PNI and other factors with Overall survival (OS). Results A total of 3301 patients were included: 47.7% were female and 52.3% were male, with a mean age of 58.7 years. By bivariate analysis, PNI was strongly associated with OS (Risk ratio [RR] 0.968, 95% Confidence interval [CI] 0.962‐0.974; P < 0.001). On multivariate analysis, PNI was an independent explanatory variable (as continuous variable and as categorized variable; RR 0.732, 95% CI 0.611‐0.878; RR 0.656, 95% CI 0.529‐0.813 and RR 0.646, 95% CI 0.521‐0.802, for quintiles 2, 3, and 4‐5, respectively); a biological gradient effect was demonstrated. The final prognostic model included PNI, location of the neoplasia in the colorectum, basal hemoglobin, lymphocyte count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, TNM stage, differentiation degree, R classification, and postoperative complications. Conclusions PNI is a significant and independent prognostic factor in patients with CRC. Its prognostic value adds precision to the TNM staging system including specific subgroups of patients with CRC; it should be evaluated in prospective clinical studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of the prognostic nutritional index and overall survival in patients with colorectal cancer: A STROBE compliant retrospective cohort study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The clinical utility of new diagnostic markers of malignancies must be evaluated to identify potentially useful methods for prognosis and treatment monitoring. In recent years, accumulating evidence has elucidated the role of inflammation-based prognostic scores, including PNI, NLR, PLR, PI, mGPS and GPS in cancer patient prognosis (12)(13)(14)(15). Although several studies have identified CAR as a prognostic factor for patients with various types of tumors (6)(7)(8), the prognostic value in patients with ESCC remained unclear (16).…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of the C‑reactive protein‑to‑albumin ratio for the prognosis of patients with esophageal squamous cell carcinoma

et al. 2017

View full text Add to dashboard Cite

“…1 a). The mGPS scores were calculated by assigning a score of 2 to patients with elevated serum CRP levels (>0.5 mg/dL) and decreased serum albumin levels (<3.5 g/dL), by assigning a score of 1 to patients with one abnormal value, and by assigning a score of 0 to patients with no abnormal values [14] . The PNI was calculated as 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm 3 ) [19] .…”

Section: Measurements Of Inflammation-and Nutrition-based Markersmentioning

confidence: 99%

“…Systemic inflammation in cases of malignancy is characterized by an imbalance between pro-and anti-inflammatory cytokines, and inflammatory markers can be used to predict prognosis in various malignancies. For example, the prognostic markers for urogenital cancer and multiple myeloma include elevated values for C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and the Glasgow Prognostic Score (GPS) [4,9,13,14] . Moreover, several reports have indicated that systemic inflammation plays a critical role in the pathogenesis of malnutrition, weight loss, and muscle loss in cachexia cases [15][16][17][18] .…”

mentioning

confidence: 99%

Integrative Assessment of Pretreatment Inflammation-, Nutrition-, and Muscle-Based Prognostic Markers in Patients with Muscle-Invasive Bladder Cancer Undergoing Radical Cystectomy

Miyake¹,

Morizawa²,

Hori³

et al. 2017

Oncology

View full text Add to dashboard Cite

Objective: The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). Methods: The analysis enrolled 117 patients and the variables included age, body mass index (BMI), neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, modified Glasgow Prognostic Score (mGPS), prognostic nutritional index (PNI), Controlling Nutritional Status score, psoas muscle index (PMI), and peak expiratory flow (PEF). The correlations among the variables were evaluated and their prognostic values after RC were tested. Results: Three inflammation markers (ratios of blood cell counts) were positively correlated (p < 0.0001). The PNI and the BMI were positively correlated (p = 0.04), although they were inversely correlated with the three inflammation markers (p < 0.0001). Age was not significantly correlated with the inflammation markers and PMI, although older age was associated with lower PNI and lower PEF. The disease-specific survival was independently predicted by T4 tumor, positive N status, and decreased PNI. Overall survival was independently predicted by T4 tumor, mGPS, and pretreatment sarcopenia status. Conclusions: The inflammation-, nutrition-, and muscle-based markers would be useful risk assessment tools for MIBC.

show abstract

Comparison of Preoperative Inflammation-based Prognostic Scores in Patients With Colorectal Cancer

Abstract: The SIS is a novel prognostic factor in CRC patients. Additionally, the SIS is an alternative inflammation-based biomarker, which may improve the prediction of clinical outcomes.

Cited by 110 publications

References 24 publications

Association of the prognostic nutritional index and overall survival in patients with colorectal cancer: A STROBE compliant retrospective cohort study

Association of the prognostic nutritional index and overall survival in patients with colorectal cancer: A STROBE compliant retrospective cohort study

Clinical significance of the C‑reactive protein‑to‑albumin ratio for the prognosis of patients with esophageal squamous cell carcinoma

Integrative Assessment of Pretreatment Inflammation-, Nutrition-, and Muscle-Based Prognostic Markers in Patients with Muscle-Invasive Bladder Cancer Undergoing Radical Cystectomy

Contact Info

Product

Resources

About