Comparison of Preoperative DOI Estimation in Oral Tongue Cancer With cN0 Disease

Au, Vivienne H.; Miller, Lauren E.; Deschler, Daniel G.; Lin, Derrick T.; Richmon, Jeremy D.; Varvares, Mark A.

doi:10.1002/ohn.314

Cited by 3 publications

(8 citation statements)

References 20 publications

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“…Two studies made comparisons between IOUS and histopathology regarding the deep margin. 16,19,23,25,32 Songra et al reported a Pearson correlation coefficient of 0.648 (P < .01) between the deep margin measured by IOUS and histopathology. 16 Baek et al compared the deep margin clearance in IOUS-assisted resection cases to that of conventional resection, and a student's t test revealed a significant difference favoring IOUS-assisted resection (P < .001).…”

Section: Ious Measurements Correlate With Final Histopathologymentioning

confidence: 99%

Intraoperative Ultrasound for the Management of Oral Tongue Cancer: a Systematic Review and Meta‐Analysis

Spence,

Au,

Zhao

et al. 2024

OTO Open

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ObjectiveTo evaluate for correlation between intraoperative ultrasound (IOUS)‐measured tumor thickness (TT) (uTT) and histopathological TT (hTT), and to compare IOUS‐assisted resection with conventional resection in patients with oral tongue cancers.Data SourcesOvid MEDLINE (1946‐2023), Embase.com (1947‐2023), and Web of Science (All Databases 1900‐2023).Review MethodsInclusion criteria were the use of IOUS for the management of oral tongue cancer. Studies that did not report quantitative data were excluded. Additionally, studies that were not contributory to meta‐analysis, or a narrative analysis of pooled results were excluded. Selection was carried out by 2 reviewers. A total of 2417 studies were initially identified, with 12 ultimately being included in this review, and 7 included in the meta‐analysis. Data were extracted by 2 investigators and were pooled using a random‐effects model.ResultsOur meta‐analysis reveals a pooled correlation coefficient of 0.92 (95% confidence interval: 0.80‐0.96) for studies comparing uTT to hTT. Studies comparing IOUS‐assisted resection to conventional resection found IOUS‐assisted resection yielded wider nearest margins in all studies reporting this outcome.ConclusionIOUS reliably measures TT, similarly to that of histopathology measurement. IOUS‐assisted resection, which allows the surgeon to view the deep extent of tumor invasion, may increase closest radial margin distance compared to conventional resection. IOUS‐assisted resection may represent a more reliable approach to achieving clear margins than conventional resection.

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Section: Ious Measurements Correlate With Final Histopathologymentioning

confidence: 99%

Intraoperative Ultrasound for the Management of Oral Tongue Cancer: a Systematic Review and Meta‐Analysis

Spence,

Au,

Zhao

et al. 2024

OTO Open

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“…Full text analysis was performed on the remaining 33 articles, and 17 articles were further excluded. The final review included 16 articles [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28], which all met the criteria for inclusion in the meta-analysis (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…In 13 studies [13,[15][16][17][20][21][22][23][24][25][26][27][28], ultrasonography was performed preoperatively. The frequencies employed ranged between a minimum of 5 and a maximum of 70 MHz (Table 1).…”

Section: Population and Studies Characteristicsmentioning

confidence: 99%

“…Au et al [27] performed intraoral ultrasound assessment of biopsy-confirmed OSCC of the tongue in clinically nodal-negative patients treated with resection. In total, 19 patients were assessed with intraoral ultrasonography, and a strong correlation between ultrasonography and histology was found (p < 0.001), with a 90% sensitivity and 78% specificity.…”

Section: Synthesis Of the Main Findings Of The Included Studiesmentioning

confidence: 99%

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The Reliability of Ultrasonographic Assessment of Depth of Invasion: A Systematic Review with Meta-Analysis

Nisi,

Gennai,

Graziani

et al. 2023

Diagnostics

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Depth of invasion (DOI) has been recognized to be a strong prognosticator for oral squamous cell carcinoma (OSCC). Several diagnostic techniques can be employed for DOI assessment, however intraoral ultrasonography has been increasingly applied for the intraoral evaluation of OSCCs. The aim of the present study is to review the evidence on the application of intraoral ultrasonography to the assessment of DOI in patients affected by OSCC. A systematic electronic and manual literature search was performed, and data from eligible studies were reviewed, selected, and extracted. The studies had to report the correlation between DOI estimated with ultrasonography versus histopathology. A meta-analysis was conducted on the quantitative data available. Sixteen articles were included in the review following the screening of the initial 228 studies retrieved from the literature. The meta-analysis showed a significant correlation between ultrasonographic and histopathologic measurements (p < 0.01). The studies were all at low/moderate risk of bias. Ultrasonography appears a valuable tool for DOI assessment.

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“…Similar to full-thickness biopsies [15], US has diagnostic value for small OSCC. However, in the case of extensive tumors, these methods do not demonstrate high DOI imaging efficiency.…”

Section: Introductionmentioning

confidence: 96%

Efficacy of Computed Tomography and Magnetic Resonance Imaging in the Assessment of Depth of Invasion in Oral Squamous Cell Carcinoma: Analysis of 125 Clinical Cases

Michcik,

Polcyn,

Garbacewicz

et al. 2023

Diagnostics

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Radiological diagnosis of oral squamous cell carcinoma (OSCC) is one of the main steps in treatment planning. T (tumor size), DOI (depth of invasion) (AJCC 8th edition), and nodal metastases (N+) were evaluated using CT and MRI to assess the most effective imaging method. The effectiveness of the radiological imaging methods was compared with histopathological results. Imaging diagnostic studies were performed and retrospectively analyzed in 125 patients with OSCC (CT n = 54 and MRI n = 71). Histopathology evaluated T, DOI, and N+. The radiological T results of CT in comparison with histopathological examination showed agreement in 62.5% of cases for T1, 56.25% for T2, 25% for T3, and 42.8% for T4 (p-value = 0.07), and regarding MRI, 52.2% for T1, 36.4% for T2, 33.3% in T3, and 33.3% for T4. The DOI results of CT and MRI juxtaposed against the histopathological findings were as follows: for CT, n = 18 for DOI ≤ 10 mm and n = 36 for >10 mm; for MRI, n = 29 for DOI ≤ 10 mm and n = 42 for >10 mm (DOI CT vs. DOI hist. pat. p-value = 0.23; DOI MRI vs. DOI hist. pat. p-value = 0.006). Regarding nodal metastasis, n = 21 for N0 and n = 32 for N+ for CT (p-value = 0.02), and n = 49 for N0 and n = 22 for N+ for MRI (p-value = 0.1). In the radiological N+ group, the histopathological findings coincided with the results of MRI and CT in 27% and 62.5% of cases, respectively (N0: 83.6% for MRI; 85.7% for CT). Upon evaluating T, a decreasing percentage of overlapping results with an increasing tumor size was observed. The accuracy of both imaging studies was at a similar level, with a slight advantage for MRI. Among the patients on whom CT was performed, DOI analysis did not show statistically significant differences. This led to the conclusion that, in most cases, the DOI results based on CT overlapped with those described via histopathological examination. However, among the group of patients with MRI as the imaging method of choice, the differences proved to be statistically significant (p-value = 0.006). The results of this study indicate that CT is a more accurate method for DOI assessment. The results of the radiologic metastasis evaluation (N+ group) overlapped more in the CT group, while the percentage of corresponding results in the radiologic N0 vs. hist. pat. N0 group was high and similar in both groups. These results indicate that it is easier to confirm the absence of a metastasis than its presence.

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Comparison of Preoperative DOI Estimation in Oral Tongue Cancer With cN0 Disease

Cited by 3 publications

References 20 publications

Intraoperative Ultrasound for the Management of Oral Tongue Cancer: a Systematic Review and Meta‐Analysis

Intraoperative Ultrasound for the Management of Oral Tongue Cancer: a Systematic Review and Meta‐Analysis

The Reliability of Ultrasonographic Assessment of Depth of Invasion: A Systematic Review with Meta-Analysis

Efficacy of Computed Tomography and Magnetic Resonance Imaging in the Assessment of Depth of Invasion in Oral Squamous Cell Carcinoma: Analysis of 125 Clinical Cases

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