Comparison of pregnancy rates following in vitro fertilization?embryo transfer between the donors and the recipients in a donor oocyte program

Check, Jerome H.; Nowroozi, Kosrow; Chase, Jeffrey S.; Nazari, Ahmad; Braithwaite, Carolyn

doi:10.1007/bf01203822

Cited by 44 publications

(29 citation statements)

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“…These data have relevance not only for oestrous synchronisation programs in cattle involving GNRH-induced ovulation but also for assisted human reproduction where oocytes derived from women undergoing COH are recovered by transvaginal preovulatory follicle aspiration and routinely replaced in the uterus of the same women during the same cycle, in contrast to the situation in cattle, where transfer to unstimulated surrogate recipients is the norm. The negative effect of ovarian stimulation on the uterine environment is highlighted by the fact that high-quality embryos transferred into unstimulated women involved as embryo recipients in a surrogacy procedure have a higher likelihood of implanting than if they are transferred back into the donors (Check et al 1992, Stafford-Bell & Copeland 2001.…”

Section: Discussionmentioning

confidence: 99%

Effect of follicular aspiration just before ovulation on corpus luteum characteristics, circulating progesterone concentrations and uterine receptivity in single-ovulating and superstimulated heifers

O'Hara

Scully²,

Maillo³

et al. 2012

Reproduction

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The aim of this study was to investigate, in unstimulated and superstimulated heifers, the effect of follicle aspiration just before ovulation on corpus luteum (CL) development, circulating progesterone (P 4 ) concentrations and the ability of the uterus to support embryo development. Following follicle aspiration or ovulation timed from GNRH administration, CL development was assessed by daily ultrasonography, and CL function was assessed in terms of the capacity to produce P 4 and the expression of genes involved in steroidogenesis in luteal tissue. The capacity of the uterine environment to support conceptus development was assessed following transfer and recovery of in vitro-produced embryos. Follicular aspiration just before the expected time of ovulation leads to a significant reduction in CL diameter, CL area and area of luteal tissue. This was associated with a decrease in circulating P 4 in both unstimulated and superstimulated heifers. Follicle aspiration leads to a reduction in conceptus length and area on day 14 in unstimulated heifers only. Follicle aspiration leads to a reduction in the expression of LHCGR in luteal tissue from unstimulated heifers compared with those in which the CL formed after ovulation. Superstimulation significantly reduced the expression of STAR in luteal tissue in both ovulated and follicle-aspirated heifers. In conclusion, in stimulated and unstimulated heifers, aspiration of the preovulatory dominant follicle(s) just before expected ovulation interferes with the subsequent formation and function of the CL, in terms of size and P 4 output and this, in turn, is associated with a reduced capacity of the uterus to support conceptus elongation in unstimulated heifers.

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Section: Discussionmentioning

confidence: 99%

Effect of follicular aspiration just before ovulation on corpus luteum characteristics, circulating progesterone concentrations and uterine receptivity in single-ovulating and superstimulated heifers

O'Hara

Scully²,

Maillo³

et al. 2012

Reproduction

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“…Current regulations in the UK are designed to ensure an equal distribution of available eggs (subject to a minimum number of eggs being available in any one cycle) between the donor and a single recipient, although eggs may be shared with a maximum of two recipients in any single cycle [48]. Although studies have shown higher pregnancy and live-birth rates for recipients than for donors, the reported results do not always achieve statistical significance [17,[26][27][28]30,31,34,36,38,49]; however, the evidence is contradictory. Research conducted by Kolibianakis et al found no significant difference in delivery rates between donors and recipients [14], while Thum et al found that both pregnancy and live-birth rates were similar for donors, egg-share recipients and women using their own gametes undergoing standard IVF [26].…”

Section: Concerns Regarding Egg Sharingmentioning

confidence: 44%

“…Egg sharing has been reported in Australia [12], Belgium [13][14][15], Canada [16], Greece [12], Spain [12], the UK [12,[17][18][19][20][21][22][23][24][25][26]103,104] and the USA [27][28][29][30][31][32][33][34][35][36][37], and was practiced in Italy until legislation passed in 2004 that prohibited all forms of donor and third-partyassisted-conception procedures [38][39]. It is the sole legally permissible form of egg donation in Denmark [3,105] and Israel [40].…”

Section: Egg Sharingmentioning

confidence: 99%

“…Several reports provide no information regarding outcomes for donors at all [29,[32][33][34]37]. Others, while providing outcome data for both donors and recipients, are restricted to pregnancy -or to pregnancy and implantation outcomes only -and provide no information regarding live births [19,28,30,31,35,36,38]. Only five studies provide data regarding live-birth outcomes for donors [14,17,25,26,34].…”

Section: Concerns Regarding Egg Sharingmentioning

confidence: 99%

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Egg sharing: a practical and ethical option in IVF?

Blyth¹,

Golding²

2008

Expert Review of Obstetrics & Gynecology

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Egg sharing is a procedure in which a woman who is herself undergoing assisted-conception treatment receives subsidized treatment in exchange for sharing her eggs with another woman. It has become increasingly prevalent in the UK and is the major source of donor eggs in the UK; however, its practice is controversial. Available evidence concerning the outcomes of egg sharing is limited. To date, while this has failed to provide strong empirical support for concerns that have been raised regarding egg sharing, continuing significant gaps in information regarding clinical and psycho-social outcomes remain, which mean that an informed judgment on empirical grounds cannot yet be made. Ongoing key ethical controversies focus on the impact of egg sharing on the commodification of human gametes and whether women can genuinely consent to donating their eggs under an egg-sharing scheme. KEYWORDS: commodification of gametes • decision making • donors • egg donation • egg sharing • informed consentTechnological developments in reproductive healthcare have increased the options available to people seeking to overcome fertility impairments -including treatments using gametes provided by a third party. In practice, although some jurisdictions prohibit donor remuneration, payment to 'donors' is common. Such payment necessarily confounds the accepted definition of 'donor'. In accordance with common usage in the assisted reproductive technologies (ART) literature, we have employed the terms 'donor' and 'donation' in this paper, but the reader should be aware of this caveat. While insemination of donor sperm has been used as a medicalized procedure for well over a century [1], IVF using donor eggs is a much more recent phenomenon; the first birth from such a procedure was reported in Australia in 1984, using an egg provided by an IVF patient [2]. It is quite possible, although the authors do not provide details of the arrangements under which the donation took place, therefore, that the very first reported birth through egg donation was in fact the result of egg sharing. Use of donor eggs is clinically indicated for women seeking to conceive who have experienced primary or secondary ovarian failure, who have functioning ovaries but for whom standard ovarian stimulation drug regimes have failed or where there is a risk of transmitting a serious genetic disorder to a child [3].Use of donor eggs has become especially prevalent in ART procedures for older women (i.e., women aged over 40 years), for two inter-related reasons; first, because of the significant decline in female fertility once women reach their mid30s [4] and the more rapid decline after the age of 40 years [101], and second, because the likelihood of successful embryo implantation is related to the age of the woman providing the egg rather than to the age of the woman in whom the embryo is implanted [5]. US data show that while fewer than 3% of all women undergoing an ART procedure during 2005 used donor eggs, 22% of women aged 41-42 years, 55% of women aged over 42 yea...

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“…Early studies showed a markedly higher pregnancy rate in the older recipients than in the younger donors [24,25]. One explanation for the difference in pregnancy rates was that the COH regimen created an adverse uterine environment [24,25].…”

Section: High Dose Vs Low Dose Gonadotropins Stimulation For Ivf-et mentioning

confidence: 99%

Mild ovarian stimulation

Check

2007

J Assist Reprod Genet

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Purpose To evaluate the efficacy of using only mild ovarian stimulation protocols for in vitro fertilization. Both groups with decreased and normal ovarian reserve were evaluated. Methods Three different mild stimulation protocols were evaluated: natural with no exogenous follicle stimulation hormone (FSH) drugs at all, natural with a boost of low dose FSH to complete follicular maturation, and minimal stimulation with low dose (75-150IU) FSH from day 3-5 of the menstrual cycle. Ethinyl estradiol was sometimes used to lower high day 3 serum FSH. Results Good pregnancy and implantation rates were found even in those women with elevated serum FSH that could only generate one follicle. Conclusions Mild ovarian stimulation seems preferable to high dose FSH regimens in women with elevated day 3 serum FSH based on previous poor reported pregnancy rates with the latter protocols. Comparable pregnancy rates to high dose regimen were seen in women with normal egg reserve at much lower risk and cost.Background leading to minimal stimulation protocol

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Comparison of pregnancy rates following in vitro fertilization?embryo transfer between the donors and the recipients in a donor oocyte program

Cited by 44 publications

References 4 publications

Effect of follicular aspiration just before ovulation on corpus luteum characteristics, circulating progesterone concentrations and uterine receptivity in single-ovulating and superstimulated heifers

Effect of follicular aspiration just before ovulation on corpus luteum characteristics, circulating progesterone concentrations and uterine receptivity in single-ovulating and superstimulated heifers

Egg sharing: a practical and ethical option in IVF?

Mild ovarian stimulation

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