Autoregulation (AR) of training involves altering resistance session parameters based upon the athlete's readiness to train. One potential benefit of AR may be that training intensity can reflect an athlete's increasing strength level throughout a training program, and can be contrasted with fixed loading (FL) where the load is stipulated at the start of the program. In this study, 31 resistance trained males participated twice weekly in an AR or a FL squat program. For the FL group load was prescribed as a percentage of the pre-test one repetition maximum whereas for the AR group load was prescribed based upon the number of "repetitions in reserve", such that the intensities were theoretically the same (volume was also matched). Both groups showed a significant increase in front (FS) and back (BS) squat performance, but the magnitude of this was significantly greater for the AR program (FS: AR +11.7%, FL +8.3%, p = 0.004, ηp 2 = 0.255; BS: AR +10.8%, FL +7.1%, p = 0.006, ηp 2 = 0.233). The AR group trained at a greater intensity (average weekly intensity; FS: AR 83.2 ± 13.3%, FL 80.4 ± 10.0%, p < 0.001, ηp 2 = 0.240; BS: AR 83.6 ± 12.7%, FL 80.4 ± 10.0%, p = 0.006, ηp 2 = 0.159). The results of this study support the contention that AR can be used to accommodate the increasing strength level of the athlete during the course of a program and that such a strategy is effective in eliciting greater strength adaptations across 12 weeks.