Comparison of postoperative plasma D‐dimer levels between patients undergoing laparoscopic resection and conventional open resection for colorectal cancer

Kubota, Yawara; Okuyama, Takashi; Oi, Haruka; Takeshita, Emiko; Mitsui, Takashi; Noro, Takuji; Sameshima, Shinichi; Noie, Tamaki; Oya, Mototsugu

doi:10.1111/ases.12796

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…26 However, the diagnostic threshold of D-dimer used to predict postoperative VTE in cancer patients is considered to be controversial. 27 Studies have shown that a postoperative D-dimer level of 1 μg/mL is an independent risk factor for VTE in urological tumors. 28 Intravenous ultrasonography in patients with D-dimer levels exceeding 3.3 μg/mL after brain tumor surgery may increase the detection rate of VTE.…”

Section: Clinical Application Value Of the Nomogram Predictive Modelmentioning

confidence: 99%

Establishment and Validation of a Postoperative VTE Prediction Model in Patients with Colorectal Cancer Undergoing Radical Resection: CRSPOT Nomogram

Wu,

Wang,

Yin

et al. 2023

Clin Appl Thromb Hemost

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Venous thromboembolism (VTE) is a life-threatening postoperative complication of malignant tumors. We identified risk factors for postoperative VTE in patients undergoing radical resection of colorectal cancer (CRC) and constructed and validated a clinical prediction model. Clinical data of 982 patients undergoing radical resection of CRC from September 1, 2020, to March 31, 2022, in Ningxia Medical University General Hospital were analyzed retrospectively. Patients were randomly divided into training ( n = 617) and validation groups ( n = 264). Data included baseline characteristics, preoperative complications, examination results, and intraoperative and postoperative indicators. Logistic regression analysis was used to determine risk factors, build a predictive model, and draw a predictive nomogram (CRSPOT). Receiver operating characteristics (ROC) curve was used to calculate the area under the curve (AUC) for evaluating the model's predictive ability. Independent risk factors for postoperative VTE were as follows: postoperative hemoglobin of <10 g/L (odds ratio [OR] 0.413, 95% confidence interval [CI] 0.220–0.777), postoperative D-dimer of ≥3.5μg/mL (OR 2.156, 95% CI 1.145–4.061), BMI of ≥25 kg/m2 (OR 2.313, 95% CI 1.225–4.369), operation time of ≥4 h (OR 2.292, 95% CI 1.232–4.262), lower extremity varicose veins (OR 4.499, 95% CI 1.764–11.476), postoperative ileus (OR 5.760, 95% CI 2.031–16.337), and postoperative hypoxemia (OR 9.230, 95% CI 4.562–18.672). The nomogram's AUC was 0.826, demonstrating a reliable predictive ability. The CRSPOT nomogram reliably predicts postoperative VTE in patients undergoing radical resection of CRC, identifying high-risk patients early, allowing early implementation of antithrombotic strategies, and helping to reduce the incidence and mortality of postoperative VTE.

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Section: Clinical Application Value Of the Nomogram Predictive Modelmentioning

confidence: 99%

Establishment and Validation of a Postoperative VTE Prediction Model in Patients with Colorectal Cancer Undergoing Radical Resection: CRSPOT Nomogram

Wu,

Wang,

Yin

et al. 2023

Clin Appl Thromb Hemost

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“…Colorectal cancer is the third most common cancer worldwide [1]. En bloc radical excision of primary tumor and regional lymph nodes by open or laparoscopic surgery, with or without neoadjuvant chemo-radiotherapy, remains the gold-standard treatment, providing cure or longterm disease-free survival with a good quality of life [2,3]. After resection, anastomotic reconstruction to restore colorectal continuity is a general procedure to realize its physiological function in complex gastrointestinal surgery.…”

Section: Introductionmentioning

confidence: 99%

Optimizing electrode design to minimize thermal spread in radiofrequency-induced colonic anastomosis

2023

PMD

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Objective: To study temperature distribution in different electrodes and to evaluate thermal spread during colonic anastomosis induced by radiofrequency energy through finite element modeling, aiming to provide the basis for optimizing the design of new electrodes with improved effectiveness of electrosurgical welding. Methods: Three electrodes with the feature of concave-convex (CC), rail coupled concave-convex (rail-CC), and cross rail coupled concave-convex (cross rail-CC) were designed for radiofrequency-induced serosa-to-serosa colonic anastomoses to evaluate the thermal spread process by finite element modeling using COMSOL Multiphysics. Parameters used in the modeling were set with a peak voltage of 45 V, a duty cycle of 10% and a repetition rate of 1 s. Additionally, a three-dimensional finite element model of the cross rail-CC electrode was further constructed to compare temperature variation and distribution when the voltage Fwas applied to ridges of upper electrode alternately. Results: The electrode with CC design produced similar temperature between 'gap' and 'compressed' areas, whereas the electrode with rail-CC design exhibited the highest temperature at 'gap' and 'compressed' areas compared with those with CC and cross rail-CC designs. Moreover, the cross rail-CC electrode, by tightly occluding the upper and lower electrodes, could create uniform compression and temperature variation. When electric voltage was applied to ridges of upper electrode of the cross rail-CC electrode alternately, the temperature at 'gap' was half of that at the 'compressed' section, which was comparable to the temperature at 'compressed' area in the rail-CC electrode (p=0.241). Conclusion: Alternating application of voltage to ridges of upper electrode of the cross rail-CC electrode can potentially produce an optimal fusion zone by reducing thermal damage with low 'gap' temperature while keeping the 'compressed' temperature high.

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“…Severe elevation is associated with a worse outcome and elevated D-Dimer levels represent a poor prognostic factor [10,11]. D-Dimer is a fibrin degradation product and elevated D-Dimer levels can be observed during deep vein thrombosis (DVT) and pulmonary embolism (PE), but also in other clinical conditions such as injuries, after surgery, during infection and inflammation or cancer [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

D-Dimer Levels Are Not Elevated in SARS-CoV-2 IgG Positive Patients Undergoing Elective Orthopedic Surgery

Jungwirth-Weinberger

Oezel

Morgenstern

et al. 2021

JCM

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Introduction: In acute COVID-19, D-Dimer levels can be elevated and those patients are at risk for thromboembolic events. This study aims to investigate differences in preoperative D-Dimer levels in SARS-CoV-2 IgG positive and negative patients undergoing primary total knee and total hip replacement (TJA) or spine surgery. Methods: D-Dimer levels of 48 SARS-CoV-2 IgG positive and 718 SARS-CoV-2 IgG negative spine surgery patients were compared to those of 249 SARS-CoV-2 IgG positive and 2102 SARS-CoV-2 IgG negative TJA patients. Patients were assigned into groups based on D-Dimer levels as follows: <200 ng/mL, 200–400 ng/mL, and >400 ng/mL D-Dimer Units (DDU). Results: D-Dimer levels did neither differ significantly between SARS-CoV-2 IgG positive spine surgery patients and TJA patients (p = 0.1), nor between SARS-CoV-2 IgG negative spine surgery and TJA patients (p = 0.7). In addition, there was no difference between SARS-CoV-2 IgG positive and negative spine surgery patients and SARS-CoV-2 IgG positive and negative TJA patients (p = 0.3). Conclusions: There is no difference in D-Dimer levels between SARS-CoV-2 IgG positive and negative patients and there does not seem to be any difference for different orthopedic specialty patients. Routine testing of D-Dimer levels is not recommended for patients undergoing elective orthopedic surgery.

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Comparison of postoperative plasma D‐dimer levels between patients undergoing laparoscopic resection and conventional open resection for colorectal cancer

Cited by 4 publications

References 23 publications

Establishment and Validation of a Postoperative VTE Prediction Model in Patients with Colorectal Cancer Undergoing Radical Resection: CRSPOT Nomogram

Establishment and Validation of a Postoperative VTE Prediction Model in Patients with Colorectal Cancer Undergoing Radical Resection: CRSPOT Nomogram

Optimizing electrode design to minimize thermal spread in radiofrequency-induced colonic anastomosis

D-Dimer Levels Are Not Elevated in SARS-CoV-2 IgG Positive Patients Undergoing Elective Orthopedic Surgery

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