Comparison of postoperative pain and inflammation reaction in dogs undergoing preventive laparoscopic-assisted and incisional gastropexy

Haraguchi, Tomoya; Kimura, Shiho; Itoh, Harumichi; Nishikawa, Shimpei; Hiyama, Masato; Tani, Kenji; Iseri, Toshie; Itoh, Yoshiki; Nakaichi, Munekazu; Taura, Yasuho; Itamoto, Kazuhito

doi:10.1292/jvms.17-0103

Cited by 22 publications

(23 citation statements)

References 30 publications

(33 reference statements)

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“…This finding is comparable to IL‐6 concentrations reported recently in healthy dogs using the same assay (mean, 3.0 pg/mL) . In our study population, the highest IL‐6 concentration was found, unexpectedly, in a single healthy dog with a mildly abnormal fibrosis score (F1; Table ).…”

Section: Resultssupporting

confidence: 90%

“…Since our research was conducted, a study of serum CRP in 46 dogs with PSS, CH, or hepatic neoplasia was published that found no differences in CRP by disease group, but did find a significant correlation between CRP and necroinflammatory activity, albeit with substantial overlap among histopathologic scores. Serum CRP is a nonspecific inflammatory marker that can increase in hospitalized dogs with a wide variety of diseases, including pancreatitis, bacterial pneumonia, and postoperative inflammation . However, CRP has been used successfully to follow response to therapy in dogs with inflammatory bowel disease or immune‐mediated polyarthritis .…”

Section: Discussionmentioning

confidence: 99%

“…Serum CRP is a nonspecific inflammatory marker that can increase in hospitalized dogs with a wide variety of diseases, 43 including pancreatitis, bacterial pneumonia, and postoperative inflammation. 25,44,45 However, CRP has been used successfully to follow response to therapy in dogs with inflammatory bowel disease or immune-mediated polyarthritis. 23,29 C-reactive protein should be evaluated as a possible tool for longitudinal monitoring in individual dogs with chronic hepatopathies without comorbidities.…”

Section: Biomarker Datamentioning

confidence: 99%

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Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease

Raghu

Ekena

Cullen

et al. 2018

Veterinary Internal Medicne

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BackgroundSerum interleukin 6 (IL‐6), chemokine ligand 2 (CCL2), C‐reactive protein (CRP), and the ratio of aspartate transaminase to alanine transaminase (AST:ALT) have been correlated with fibrosis and necroinflammatory activity in humans with various hepatopathies.Hypothesis/ObjectivesTo determine whether increases in serum IL‐6, CCL2, CRP, or AST:ALT were associated with moderate to severe fibrosis or necroinflammatory activity in dogs with various hepatopathies.AnimalsForty‐four client‐owned dogs with clinical evidence of liver disease and 10 healthy purpose‐bred dogs, all undergoing liver biopsies by laparoscopy or laparotomy.MethodsMeasurement of serum IL‐6, CCL2, CRP, AST, and ALT before scheduled liver biopsy and evaluation of liver histopathology using the METAVIR scoring system used in human medicine, blinded to clinical presentation.ResultsMedian serum IL‐6 was approximately twice as high in dogs with high fibrosis scores (15.5 pg/mL; range, 1.4 to 235 pg/mL) compared to dogs with low fibrosis scores (7.6 pg/mL; range, 1.4 to 148.1 pg/mL), with marginal significance (P = .05). Median serum CCL2 was significantly higher in dogs with active necroinflammation (444 pg/mL; range, 144 to 896 pg/mL) compared to dogs without detectable necroinflammation (326 pg/mL; range, 59 to 1692 pg/mL; P = .008), but with considerable overlap between groups. Neither serum CRP nor AST:ALT ratios were significantly different based on fibrosis or necroinflammatory scores.Conclusions and Clinical ImportanceBecause of substantial variability among dogs, single measurements of IL‐6 and CCL2 have limited diagnostic utility for identifying fibrosis or necroinflammation, respectively, in dogs with various chronic liver diseases. The value of these biomarkers should be explored further in monitoring response to treatment in individual dogs with chronic hepatopathies.

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Section: Resultssupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Biomarker Datamentioning

confidence: 99%

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Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease

Raghu

Ekena

Cullen

et al. 2018

Veterinary Internal Medicne

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“…TNF-a regulates the release of cytokines and CRP through nuclear factor-kB activation. CRP is used to monitor the postoperative course in surgical trauma (Haraguchi et al, 2017). Its serum concentration is very low in healthy subjects but increases rapidly in cases of inflammation, infection, and traumatic injury.…”

Section: Discussionmentioning

confidence: 99%

Low-Dose Dexmedetomidine Accelerates Gastrointestinal Function Recovery in Patients Undergoing Lumbar Spinal Fusion

Wang

Xiao

et al. 2019

Front. Pharmacol.

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Background: Dexmedetomidine possesses sedative, sympatholytic, and opioid-sparing properties, but its impact on postoperative gastrointestinal function is controversial.Methods: This single-center, prospective, randomized study compared low-dose dexmedetomidine and placebo on gastrointestinal function recovery and inflammation after posterior lumbar spinal fusion. Sixty-six patients were randomized into two groups and received normal saline (control group) or dexmedetomidine (DEX group) during posterior lumbar fusion. Blood was taken at five timepoints to measure lipopolysaccharides, tumor necrosis factor-a, and C-reactive protein. The primary outcome was duration to first flatus. The secondary outcomes were inflammatory mediators and determination of correlations between perioperative factors and duration to first flatus.Results: Patients in DEX group showed significantly lower duration to first flatus (15.37 [13.35-17.38] vs 19.58 [17.31-21.86] h; p = 0.006) and overall sufentanil consumption (67.19 [63.78-70.62] vs 74.67 [69.96-79.30] mg; p = 0.011) than controls. Lipopolysaccharides, tumor necrosis factor-a, and C-reactive protein did not differ between the groups at any timepoint (all p > 0.05). Multiple linear regression modeling assessed the ability of independent variables to predict variance in duration to first flatus (adjusted R 2 = 0.379, p = 0.000). In the model, age (b = 0.243, p = 0.003), gender (b = −3.718, p = 0.011), BMI (b = −0.913, p = 0.001), operative segments (b = −4.079, p = 0.028), and overall sufentanil consumption (b = 0.426, p = 0.000) contributed significantly.Conclusions: Thus, low-dose dexmedetomidine accelerates gastrointestinal function recovery after lumbar spinal fusion. The effect may be partially produced by opioid-sparing effects rather than inhibition of inflammation.Clinical Trial Registration: www.chictr.org.cn, identifier ChiCTR1800018127.

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“…Classification of studies by organ system is presented in Tables S1 and S2. Numbers of studies and participants were reported within each organ/system group including female genital tract (22 studies [n = 1407 dogs]), 1,7,11,20,30‐47 urinary tract (7 studies [n = 114]), 3,48‐53 stomach (9 studies [n = 250]), 10,18,54‐59 intestinal tract (5 studies [n = 48]), 60‐64 liver (5 studies [n = 288]), 12,17,65‐67 adrenal gland (5 studies [n = 62]), 13,28,68‐70 spleen (7 studies [n = 111]), 19,71‐76 and other (4 studies that included gastropexy and ovariectomy procedures [n = 148]) 9,77‐79 . One experimental study, in which colopexy in seven male dogs was described, was classified as intestinal tract even though these dogs were also sterilized during the surgical procedure because this study reported only complications and outcomes related to colopexy 63 .…”

Section: Resultsmentioning

confidence: 99%

A systematic review of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs

et al. 2020

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Objective To evaluate and report the quality of the scientific literature reporting complications associated with laparoscopic and laparoscopic‐assisted procedures in client‐owned or healthy research dogs and to report and illustrate laparoscopic complications related to individual organ systems. Study design Systematic review. Animals Client‐owned or healthy research dogs. Methods A literature review was performed by using PubMed and CAB abstracts for English‐language studies providing descriptions of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs. Study selection used PRISMA (Preferred Reporting Items for Systematic reviews and Meta‐Analyses) guidelines. Quality assessment was performed by using a MINORS (Methodological Items for Non‐Randomized Studies) scoring system and a grading scale of level of evidence. Descriptive statistics were used. Results In total, 741 manuscripts were identified, with 64 manuscripts eligible for data extraction and quality assessment. The most represented organ system was the female genital tract, represented by 22 (34.4%) studies. The most commonly reported intraoperative and postoperative complications were related to abdominal entry and portal incisions, respectively. In 53 of 54 non‐randomized studies, high risk of bias was found. Forty‐eight (75%) studies provided level III or IV evidence. Conclusion This report provides an updated review of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs, classified by organ system. The overall quality of evidence was low, limiting direct comparison of complication rates between studies. Clinical significance There is a need for implementation of standardized criteria for defining complications, study time frames and greater numbers of high quality prospective randomized trials in veterinary laparoscopy to permit comparison of complication and conversion rates between published studies and across organ systems.

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Comparison of postoperative pain and inflammation reaction in dogs undergoing preventive laparoscopic-assisted and incisional gastropexy

Cited by 22 publications

References 30 publications

Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease

Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease

Low-Dose Dexmedetomidine Accelerates Gastrointestinal Function Recovery in Patients Undergoing Lumbar Spinal Fusion

A systematic review of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs

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