Comparison of postmortem ultrasound and X-Ray with autopsy in fetal death: Retrospective study of 169 cases

Prodhomme, O.; Baud, C.; Saguintaah, M.; Béchard-Sevette, Nancy; Bolivar, Julie; David, Stéphanie; Taleb-Arrada, Ikram; Couture, A.

doi:10.1016/j.jofri.2015.04.002

Cited by 13 publications

(20 citation statements)

References 18 publications

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“…On the basis of study title and abstract, 5999 articles were excluded and 18 articles were retrieved in full text. After review of the full text, four studies were eventually included in the systematic review 17–20. A PRISMA flowchart is shown in figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Our patient and study characteristics are provided in tables 1 and 2. All four articles related to PMUS for perinatal deaths 17–20. In all studies, parental consent was given for the ultrasound imaging.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of studies (3/4, 75%) were prospective in design and conducted in a single centre (3/4, 75%). Two studies originated from France,18 19 one study originated from Belgium20 and one was a multicentre study involving patients from two institutions, one in the UK and one in Belgium 17. The timeframe for data collection ranged between 1 and 4 years.…”

Section: Resultsmentioning

confidence: 99%

“…For all cases, the ultrasound was performed prior to autopsy (therefore without knowledge of the reference test results). In two studies (2/4, 50%), the operators were blinded to the antenatal history,17 19 and in the remainder the antenatal results were known to the operator 18 20. The operator was frequently a paediatric radiologist (3/5, 60%) or fetal medicine specialist with ultrasound experience (2/5, 40%).…”

Section: Resultsmentioning

confidence: 99%

“…All of the studies reported that their autopsies were performed according to national guidelines (ie, Royal College of Pathologists,22 23 SOFFoeT,24 French National Authority of Health) 25. In one study, the autopsy guideline was not mentioned 18…”

Section: Resultsmentioning

confidence: 99%

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Diagnostic accuracy of perinatal post-mortem ultrasound (PMUS): a systematic review

Shelmerdine

Langan²,

Sebire

et al. 2019

bmjpo

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ObjectiveUltrasound is ubiquitous in live paediatric imaging; however, its usage in post-mortem setting is less established. This systematic review aims to evaluate the diagnostic accuracy of paediatric post-mortem ultrasound (PMUS).DesignMEDLINE, Embase and Cochrane Library databases were queried for studies published between 1998 and 2018 assessing PMUS diagnostic accuracy rates in children<18 years old, using autopsy as reference standard. Risk of bias was assessed using Quality Assessment of Diagnostic Accuracy Studies 2. A bivariate random-effects model was used to obtain combined mean estimates of sensitivity and specificity for different body systems.ResultsFour studies were included, all relating to ultrasound for perinatal deaths. The mean diagnostic sensitivity and specificity for neurological abnormalities were 84.3% (95% CI: 70.8% to 92.2%) and 96.7% (95% CI: 86.5% to 99.3%); for cardiothoracic abnormalities 52.1% (95% CI: 27.6% to 75.5%,) and 96.6% (95% CI: 86.8% to 99.2%); and for abdominal abnormalities 78.4% (95% CI: 61.0% to 89.4%) and 97.3% (95% CI: 88.9% to 99.4%). Combining all body systems, the mean sensitivity and specificity were 73.3% (95% CI: 59.9% to 83.5%) and 96.6% (95% CI: 92.6% to 98.4%).ConclusionsPMUS demonstrates a reasonable diagnostic accuracy, particularly for abdominal and neurological abnormalities, although cardiac anomalies were less readily identified.Trial registration numberCRD42018106968.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic accuracy of perinatal post-mortem ultrasound (PMUS): a systematic review

Shelmerdine

Langan²,

Sebire

et al. 2019

bmjpo

View full text Add to dashboard Cite

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Latest developments in post‐mortem foetal imaging

et al. 2019

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A sustained decline in parental consent rates for perinatal autopsies has driven the development of less‐invasive methods for death investigation. A wide variety of imaging modalities have been developed for this purpose and include post‐mortem whole body magnetic resonance imaging (MRI), ultrasound, computed tomography (CT) and micro‐focus CT techniques. These are also vital for “minimally invasive” methods, which include potential for tissue sampling, such as image guidance for targeted biopsies and laparoscopic‐assisted techniques. In this article, we address the range of imaging techniques currently in clinical practice and those under development. Significant advances in high‐field MRI and micro‐focus CT imaging show particular promise for smaller and earlier gestation foetuses. We also review how MRI biomarkers such as diffusion‐weighted imaging and organ volumetric analysis may aid diagnosis and image interpretation in the absence of autopsy data. Three‐dimensional printing and augmented reality may help make imaging findings more accessible to parents, colleagues and trainees.

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Diagnostic accuracy of postmortem ultrasound vs postmortem 1.5‐T MRI for non‐invasive perinatal autopsy

Shelmerdine

Sebire

Arthurs

2021

Ultrasound in Obstet & Gyne

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Objectives To determine the diagnostic accuracy of postmortem magnetic resonance imaging (PM‐MRI) and postmortem ultrasound (PM‐US) for perinatal autopsy in the same patient cohort, and to determine whether PM‐US can provide the same anatomical information as PM‐MRI. Methods In this prospective, 5‐year (July 2014–July 2019) single‐center study, we performed 1.5‐T PM‐MRI and PM‐US in an unselected cohort of perinatal deaths. The diagnostic accuracies of both modalities were calculated, using autopsy as the reference standard. As a secondary objective, the concordance rates between the two imaging modalities for the overall main diagnosis and for five anatomical regions (brain, spine, thorax, heart and abdomen) were calculated. Results During the study period, 136 cases underwent both PM‐US and PM‐MRI, of which 88 (64.7%) also underwent autopsy. There was no significant difference in the rates of concordance with autopsy between the two modalities for overall diagnosis (PM‐US, 86.4% (95% CI, 77.7–92.0%) vs PM‐MRI, 88.6% (95% CI, 80.3–93.7%)) or in the sensitivities and specificities for individual anatomical regions. There were more non‐diagnostic PM‐US than PM‐MRI examinations for the brain (22.8% vs 3.7%) and heart (14.7% vs 5.1%). If an ‘imaging‐only’ autopsy had been performed, PM‐US would have achieved the same diagnosis as 1.5‐T PM‐MRI in 86.8% (95% CI, 80.0–91.5%) of cases, with the highest rates of agreement being for spine (99.3% (95% CI, 95.9–99.9%)) and cardiac (97.3% (95% CI, 92.4–99.1%)) findings and the lowest being for brain diagnoses (85.2% (95% CI, 76.9–90.8%)). Conclusion Although there were fewer non‐diagnostic cases using PM‐MRI than for PM‐US, the high concordance rate for overall diagnosis suggests that PM‐US could be used for triaging cases when PM‐MRI access is limited or unavailable. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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Comparison of postmortem ultrasound and X-Ray with autopsy in fetal death: Retrospective study of 169 cases

Cited by 13 publications

References 18 publications

Diagnostic accuracy of perinatal post-mortem ultrasound (PMUS): a systematic review

Diagnostic accuracy of perinatal post-mortem ultrasound (PMUS): a systematic review

Latest developments in post‐mortem foetal imaging

Diagnostic accuracy of postmortem ultrasound vs postmortem 1.5‐T MRI for non‐invasive perinatal autopsy

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