Comparison of postasphyxial resuscitation with 100% and 21% oxygen on cortical oxygen pressure and striatal dopamine metabolism in newborn piglets

Huang, Cheng‐Hung; Yonetani, Masahiko; Lajevardi, Nasser S.; Delivoria‐Papadopoulos, Maria; Df, Wilson; Pastuszko, Anna

doi:10.1016/0300-9572(95)94122-p

Cited by 14 publications

(15 citation statements)

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“…Increasing FiO 2 levels facilitates posthypoxic cerebral cortical hyperoxia (47) and results not only in cerebral, but also in systemic, oxidative damage (48). Although the blood oxidative stress indicator levels in our study did not reveal any significant liberation of potentially highly damaging mediators, on the basis of previously published observations (12,49) (as there were no other significant differences between the two asphyxiated groups apart from the arterial PO 2 values) we presume the deleterious effects of hyperoxia on the neuronal cell membranes were caused either by increasing cerebral dopamine concentration (50,51) or by other lipid peroxidation products (52-55) not measured here. It also seems likely that the oxidative stress remained localized within the CNS, and the elevations in the biochemical markers become lost on dilution in the plasma (56).…”

Section: Discussionsupporting

confidence: 63%

Impaired Early Neurologic Outcome in Newborn Piglets Reoxygenated with 100% Oxygen Compared with Room Air after Pneumothorax-Induced Asphyxia

et al. 2001

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Section: Discussionsupporting

confidence: 63%

Impaired Early Neurologic Outcome in Newborn Piglets Reoxygenated with 100% Oxygen Compared with Room Air after Pneumothorax-Induced Asphyxia

et al. 2001

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“…ROOM AIR VS OXYGEN: LONG-TERM OUTCOME higher in Re-O 2 piglets compared with Re-Air animals following systemic hypoxic injury (19). Although, early assessment of the neurofunction is an important outcome measure, the late assessment of neurohandicap ultimately defines the efficacy of therapeutic interventions in asphyxiated neonates.…”

mentioning

confidence: 99%

Reoxygenation with 100% Oxygen Versus Room Air: Late Neuroanatomical and Neurofunctional Outcome in Neonatal Mice with Hypoxic-Ischemic Brain Injury

et al. 2006

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Study investigated neuroutcome in mice subjected at 7-8 d of life to hypoxic-ischemic brain injury (HI) followed by 30 min of reoxygenation with 100% O 2 (Re-O 2 ) or room air (Re-Air). At 24 h of recovery, mouse reflexes were tested. At 7 wks after HI spatial orientation and memory were assessed in the same mice. Mortality rate was recorded at 24 h and at 7 wks of recovery. In separate cohort of mice, changes in cerebral blood flow (CBF) during HI-insult and reoxygenation were recorded. T he resuscitation of asphyxiated neonates is aimed to reestablish tissue oxygen delivery by restoring blood flow and increasing the arterial oxygen content. Use of 100% O 2 during neonatal resuscitation is currently recommended (1). However, Re-O 2 compared with Re-Air significantly exacerbates an oxidative stress in asphyxiated neonates (2), which is one of the mechanisms of HI-brain injury (3). To avoid hyperoxia-induced oxidative stress, the efficacy of resuscitation with room air (RA) instead of 100% O 2 is being extensively studied. To date, results of these studies are conflicting. For instance, it was reported that in asphyxiated pigs the Re-O 2 restored CBF significantly faster and more complete compared with Re-Air (4). Significantly higher levels of excitatory amino acids were found in the striatum of newborn HI-piglets Re-Air compared with Re-O 2 piglets which may be indicative of less favorable neurologic prognosis for Re-Air animals (5). However, Liu. Y and co-authors, using a canine model of cardiac arrest, demonstrated that Re-O 2 versus ReAir resulted in greater neurologic impairment assessed at 24 h of recovery (6). In contrast, the postischemic use of hyperbaric oxygenation, which produces substantial oxidative stress (7), significantly improved neurologic score following focal cerebral ischemia in adult rats and HI in neonatal rats (8,9). Hyperbaric oxygenation used as a mode of resuscitation from experimental heatstroke in rats was shown to be significantly neuroprotective (10). Meier and co-authors reported that hyperoxic ventilation significantly reduced short-term (6 h) mortality due to systemic ischemia following an acute hemorrhagic shock in pigs (11). The most recent meta-analysis indicates that there are not enough data to challenge current recommendation of using of pure O 2 during resuscitation (12).The assessment of long-term neurologic handicap following HI is of paramount clinical value to define the ultimate efficacy of Re-O2 versus Re-Air in an asphyxiated subject. There are no reports on late neurologic outcome and reoxygenation strategy following asphyxia. This work was undertaken to provide experimental data on short-and long-term neuropathological and neurofunctional outcomes in HIaffected mice re-oxygenated with either 100% O 2 or RA immediately following the index event. MATERIALS AND METHODSMurine model of HI. Three day old (p3) C57/BL6J mice of both genders were purchased from Jackson Laboratories (Bar Harbor, ME) with their birth mothers. All research was conducted according ...

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“…The level of development of the neonatal pig's brain is comparable with that of a term human newborn (10). A potential weakness of our study design may be that the experiments were performed on animals that had undergone the transition from intra to extrauterine life.…”

Section: Discussionmentioning

confidence: 99%

“…Alternatives to today's ventilation and chest compression guidelines may be easier to perform and teach and should be considered if the brain inflammatory response is of similar intensity. We chose to study a spectrum of inflammation markers in cerebrospinal fluid (CSF) and brain tissue by quantification of cytokines, interleukin-6 (IL-6) (7-9) and tumor necrosis factor-α (TNF-α) (10) and S100 (11,12) in CSF, and gene expression of matrix metalloproteinases (MMPs) (13,14), intercellular adhesion molecule 1 (ICAM-1) (15)(16)(17), the apoptosis-related cysteine peptidase caspase 3 (14), and cytokines IL-6 and TNF-α in the hippocampus and frontal cortex tissue. On the basis of our previous papers on return of spontaneous circulation (ROSC) (18)(19)(20)(21), we aimed to find out if initial ventilation periods longer than 30 s, compression-to-ventilation (C:V) ratios other than the 3:1, or air instead of pure oxygen may induce less brain injury and inflammation in extremely sick pigs.…”

mentioning

confidence: 99%

Brain inflammation induced by severe asphyxia in newborn pigs and the impact of alternative resuscitation strategies on the newborn central nervous system

et al. 2012

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Background:We compared the current guidelines for neonatal resuscitation with alternative measures and aimed to find out whether this modulated brain inflammation. Methods: Progressive asphyxia was induced in 94 newborn pigs until asystole. With the reference being resuscitation guidelines, 30 s of initial positive-pressure ventilation before compression (c) and ventilation (V) (c:V; 3:1) in 21% oxygen, pigs were randomized to (i) ventilation for 30, 60, or 90 s before chest compressions; (ii) c:V ratios of 3:1, 9:3, or 15:2; or (iii) 21% or 100% oxygen. concentrations of inflammatory markers in the cerebrospinal fluid (csF) and gene expression in the hippocampus and frontal cortex were measured for different interventions. results: In csF, s100 was higher with 90 s than with 30 or 60 s of initial positive-pressure ventilation, whereas concentrations of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were higher with 30 than with 60 s. Matrix metalloproteinase-2 (MMP-2) and intracellular adhesion molecule 1 (IcaM-1) were higher with 30 than with 60 s. No other comparison between ratios and oxygen concentrations used yielded significant results. conclusion: With respect to signs of brain inflammation, newly born pigs at asystole should be ventilated for longer than 30 s before chest compressions start. c:V ratios of 9:3 and 15:2 as compared with 3:1, or air instead of pure oxygen, did not modulate inflammatory markers.

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Comparison of postasphyxial resuscitation with 100% and 21% oxygen on cortical oxygen pressure and striatal dopamine metabolism in newborn piglets

Cited by 14 publications

References 0 publications

Impaired Early Neurologic Outcome in Newborn Piglets Reoxygenated with 100% Oxygen Compared with Room Air after Pneumothorax-Induced Asphyxia

Impaired Early Neurologic Outcome in Newborn Piglets Reoxygenated with 100% Oxygen Compared with Room Air after Pneumothorax-Induced Asphyxia

Reoxygenation with 100% Oxygen Versus Room Air: Late Neuroanatomical and Neurofunctional Outcome in Neonatal Mice with Hypoxic-Ischemic Brain Injury

Brain inflammation induced by severe asphyxia in newborn pigs and the impact of alternative resuscitation strategies on the newborn central nervous system

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