Comparison of Positron Emission Tomography Scanning and Sentinel Node Biopsy in the Detection of Inguinal Node Metastases in Patients With Anal Cancer

Mistrangelo, Massimiliano; Pelosi, Ettore; Bellò, Marilena; Castellano, Isabella; Cassoni, Paola; Ricardi, Umberto; Muñoz, Fernándo; Racca, Patrizia; Contu, Viviana; Beltramo, G.; Morino, Mario; Mussa, Antonio

doi:10.1016/j.ijrobp.2009.04.020

Cited by 66 publications

(37 citation statements)

References 18 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On completion of pre-treatment assessment, patients were submitted to combined radiochemotherapy (RCT) treatment (Mistrangelo et al , 2009a; Mistrangelo et al , 2010; Mistrangelo et al , 2012). Inguinal radiotherapy was administered only to patients with metastatic inguinal lyph nodes at SLNB.…”

Section: Methodsmentioning

confidence: 99%

Value of staging squamous cell carcinoma of the anal margin and canal using the sentinel lymph node procedure: an update of the series and a review of the literature

et al. 2013

View full text Add to dashboard Cite

Background:Inguinal metastases in patients affected by anal cancer are an independent prognostic factor for local failure and overall mortality. Since 2001, sentinel lymph node biopsy was applied in these patients. This original study reports an update of personal and previous published series, which were compared with Literature to value the incidence of inguinal metastases T-stage related and the overall incidence of false negative inguinal metastases at sentinel node.Methods:In all, 63 patients diagnosed with anal cancer submitted to inguinal sentinel node. Furthermore a research in the Pub Med database was performed to find papers regarding this technique.Results:In our series, detection rate was 98.4%. Inguinal metastases were evidentiated in 13 patients (20.6%). Our median follow-up was 35 months. In our series, no false negative nodes were observed.Conclusion:Sentinel node technique in the detection of inguinal metastases in patients affected by anal cancer should be considered as a standard of care. It is indicated for all T stages in order to select patients to be submitted to inguinal radiotherapy, avoiding related morbidity in negative ones. An overall 3.7% rate of false negative must be considered acceptable.

show abstract

Section: Methodsmentioning

confidence: 99%

Value of staging squamous cell carcinoma of the anal margin and canal using the sentinel lymph node procedure: an update of the series and a review of the literature

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Mistrangelo et al [50] compared SLNB and 18 F-FDG PET/CT to determine which method was better for staging inguinal lymph nodes in patients with anal cancer. Twenty-seven anal cancer patients underwent both inguinal SLNB and 18 F-FDG PET/CT.…”

Section: Anal Cancermentioning

confidence: 99%

Comparison between 18F-FDG PET (PET/CT) and sentinel lymph node biopsy in the detection of regional lymph node metastasis of various malignancies: review of the literature

Qiu

Chen²

2013

JBGC

View full text Add to dashboard Cite

This article reviewed comparative studies of the use of 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) or positron emission tomography/computed tomography (PET/CT) and sentinel lymph node biopsy (SLNB) for the detection of regional lymph node metastasis in patients with various malignancies. We sought to evaluate the diagnostic accuracy of 18 F-FDG PET (PET/CT) compared with SLNB to determine the presence or absence of regional lymph node metastasis. In this paper, we review 15 comparative studies of breast tumors and 17 comparative studies of melanomas that used these methods to detect regional lymph node metastasis. Original articles for other malignancies, including oral and oropharyngeal carcinoma, penile carcinoma, anal cancer, and cervical cancer, are relatively scarce. A consensus has been reached in the literature that SLNB is much more sensitive than 18 F-FDG PET and PET/CT for detecting small lymph node metastasis. 18 F-FDG PET and PET/CT cannot replace SLNB for the evaluation of early-stage regional lymphatic tumor dissemination in this patient population.

show abstract

“…However, upstaging related to lymph node metastases might have been overestimated, as up to 31 % of inguinal metastases identified by PET/CT are reportedly false positives [30].…”

Section: Diagnosismentioning

confidence: 99%

The treatment of squamous anal carcinoma: guidelines of the Italian society of colo-rectal surgery

2012

View full text Add to dashboard Cite

The Italian society of colo-rectal surgery (SICCR) is dedicated to improving the study, prevention and management of the diseases of the colon, rectum and anus. One of the aims of the society is to establish guidelines to the treatment of these diseases. These guidelines are based on the international literature and on the best available evidence. Clinical practice guidelines are one of the most important instruments to provide therapeutic decision-making support, based on the best scientific evidence available at the time. Guidelines are advisory and not prescriptive, susceptible to continual variations secondary to innovations and new scientific evidence. These guidelines are a guide for all colo-rectal surgeons and physicians who approach anal cancer.

show abstract

Comparison of Positron Emission Tomography Scanning and Sentinel Node Biopsy in the Detection of Inguinal Node Metastases in Patients With Anal Cancer

Cited by 66 publications

References 18 publications

Value of staging squamous cell carcinoma of the anal margin and canal using the sentinel lymph node procedure: an update of the series and a review of the literature

Value of staging squamous cell carcinoma of the anal margin and canal using the sentinel lymph node procedure: an update of the series and a review of the literature

Comparison between 18F-FDG PET (PET/CT) and sentinel lymph node biopsy in the detection of regional lymph node metastasis of various malignancies: review of the literature

The treatment of squamous anal carcinoma: guidelines of the Italian society of colo-rectal surgery

Contact Info

Product

Resources

About