ObjectivesThis study evaluated the clinical performance of bulk‐fill resin composite systems with different viscosities in class II cavities.Materials and MethodsA total of 80 class II restorations were performed with a single operator in 50 patients using four different bulk‐fill resin composite materials: Filtek™ Bulk Fill, Heated Filtek™ Bulk Fill, G‐ænial™ BULK Injectable, and SonicFill3. A double‐blinded randomized clinical trial was designed to evaluate the two‐year clinical performance of the four bulk‐fill composite resins using modified FDI criteria.Data were analyzed descriptively. Level of significance was set at 0.05. Differences between groups were tested using Wilcoxon‐signed‐rank and Mann–Whitney‐U test as nonparametric tests.ResultsData were analyzed using Kruskal‐Wallis, Mann–Whitney U, and Wilcoxon signed rank tests (p < 0.05). Eighty restorations were available for evaluation, with a survival function of 100%. No statistically significant differences were observed between the four groups regarding assessing esthetic, functional, and biological properties during different follow‐up periods.ConclusionsAfter 2 years of clinical follow‐up, the bulk‐fill composite systems with different viscosities seem to be esthetically, functionally, and biologically acceptable, with a promising clinical performance in class II cavities.