Comparison of polycyclic aromatic hydrocarbon metabolite concentrations in urine of mothers and their newborns

Urbancová, Kateřina; Dvořáková, Darina; Gramblicka, Tomas; Šrám, Radìm J.; Hajšlová, Jana; Pulkrabová, Jana

doi:10.1016/j.scitotenv.2020.138116

Cited by 26 publications

(22 citation statements)

References 29 publications

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“…In our previous study [14], we have observed higher concentrations of urinary OH-PAHs of newborns from Most compared to the second sampling location Ceske Budejovice, but the concentrations of benzo[a]pyrene (BaP) in ambient air in both of these locations are similar. Therefore, we hypothesized that the population of highly polluted mining districts at 40-50 years ago can carry some long-term changes (maybe changes in the genetic information) which also affect the metabolism of PAHs [15].…”

Section: Introductionmentioning

confidence: 86%

Possible Relationship between Respiratory Diseases and Urinary Concentrations of Polycyclic Aromatic Hydrocarbon Metabolites

Urbancová¹,

Vondraskova²,

Solanský³

et al. 2022

Preprint

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Aim: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been in the past associated with adverse effects on human health among which belong also respiratory diseases. Our study is focused on the evaluation of PAH exposure by measuring the concentrations of their monohydroxylated metabolites (OH-PAHs) in urine and comparing their concentrations with the incidence of respiratory diseases in 2-year-old children from two locations of the Czech Republic – a control locality Ceske Budejovice and a previously highly contaminated mining district Most. Methods: The total number of 248 participants were sampled for urine samples that were analysed for the presence of 11 OH-PAHs using liquid-liquid extraction with ethyl acetate and clean-up employing dispersive solid phase extraction with a sorbent Z-Sep. Separation, identification and quantification of the target compounds was achieved by ultra-high performance liquid chromatography coupled to tandem mass spectrometry. The incidence of respiratory diseases was evaluated according to the questionnaires provided by the paediatricians. Results and discussion: The concentrations of measured OH-PAHs were higher in the urine samples collected from 2-year-old children living in Most compared to 2-year-old children from Ceske Budejovice. The same trend was observed also when the urine samples were analysed when these children were studied as newborns in our previous study. From all of the monitored respiratory diseases, only influenza due to unidentified influenza virus showed a difference between tested locations where the 2-year-old children living in Most were more frequently diagnosed with this disease. Conclusion: Even though the air pollution and lifestyle in both cities is very similar, we have observed higher incidence of respiratory diseases as well as higher concentration of OH-PAHs in urine of the 2-year-old children from Most. Therefore, we hypothesize that the population living in this previously highly contaminated location (in 1970s and 1980s) can carry some long-term health burden.

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Section: Introductionmentioning

confidence: 86%

Possible Relationship between Respiratory Diseases and Urinary Concentrations of Polycyclic Aromatic Hydrocarbon Metabolites

Urbancová¹,

Vondraskova²,

Solanský³

et al. 2022

Preprint

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“…Benzo[a]pyrene (BaP), as a part of the high molecular weight of PAH compounds, tends to accumulate in the adipose tissue and only a small part of it is metabolized in the body. However, most of the fluorine or phenanthrene is metabolized in the body as a low molecular weight of PAHs (Dejmek et al 2000 , Abdel-Shafy and Mansour 2016 , Urbancova et al 2020 ). Metabolism of PAHs occurs in the body by cytochrome P450 enzymes.…”

Section: Introductionmentioning

confidence: 99%

“…In the first phase, mainly OH-PAHs are formed. In the second phase, these compounds with glucuronic acid or sulfate produce compounds that are excreted in the urine due to their high solubility in water (Tombolini et al 2018 , Urbancova et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…In the first phase, for example, formed reactive species can increase cancer in humans by reacting with DNA and proteins in the human body. PAHs can also have numerous negative effects on children’s health by increasing respiratory problems, bronchial asthma, and risk of cancer (Freire et al 2009 , Urbancova et al 2020 ). In addition, PAH compounds share a similar mechanism of carcinogenic action in both experimental animals and humans (Watson et al 1988 ; Shamsedini et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

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Exposure assessment of children living in homes with hookah smoking parents to polycyclic aromatic hydrocarbons: urinary level, exposure predictors, and risk assessment

Tabatabaei

Shamsedini

Mohammadpour

et al. 2022

Environ Sci Pollut Res

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Children are extremely liable to indoor air pollutants as their physiology and a few metabolic pathways are different from those of adults. The present cross-sectional study aimed to assess exposure of children living with parents who use hookah tobacco smoke to polycyclic aromatic hydrocarbons (PAHs) using a biomonitoring approach. The study was conducted on 25 children (7–13 years of age) exposed to hookah smoke at home and 25 unexposed age-matched children. Urinary levels of five metabolites of PAHs were quantified via headspace gas chromatography-mass spectrometry (GC–MS). Urinary malondialdehyde (MDA) was measured, as well. Information regarding the sociodemographic and lifestyle conditions was collected through interviews using managed questionnaires. The urinary 1-OH-NaP and 9-OH-Phe concentrations were respectively 1.7- and 4.6-folds higher in the case samples compared to the control group ( p < 0.05). In addition, urinary MDA levels were 1.4 times higher in the exposed children than in the unexposed group, but the difference was not statistically significant ( p > 0.05). Increasing the consumption of grilled and meat food in the diet increased the participants’ urinary 2-OH-Flu and 1-OH-Pyr levels, respectively. Moreover, sleeping in the living room instead of the bedroom at night was a significant predictor of high 1-OH-NaP and 2-OH-NaP concentrations in the children’s urine. Overall, the findings confirmed that children living in their homes with hookah-smoking parents were significantly exposed to naphthalene and phenanthrene. Hence, implementing protective measures is critical to reduce the exposure of this group of children. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-022-20589-0.

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“…However, due to the fact that humans are exposed to a mixture of PAHs, the biomonitoring of other urinary hydroxylated PAHs would give us a more comprehensive assessment of PAH exposure [ 25 ]. In fact, the metabolites of urinary PAHs, including naphthalene, fluorene, phenanthrene, and pyrene, are commonly presented as indicators of exposure to PAHs in several research [ 26 , 27 ]. Nevertheless, the random variation, including urine flow rate (UFR), may confound the interpretation of the association between urinary concentration and health outcomes.…”

Section: Introductionmentioning

confidence: 99%

Clinical Relevance of Urine Flow Rate and Exposure to Polycyclic Aromatic Hydrocarbons

Jeng

Huang

Wang

et al. 2021

IJERPH

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Background: Polycyclic aromatic hydrocarbon (PAH) metabolites have received increasing attention because several of these organic substances are highly carcinogenic or mutagenic. Exposure to PAHs is associated with many harmful health effects; however, we are not aware of any study that has explored the exposure to PAHs and urinary conditions in the general population. The present work aimed to investigate the correlation among PAH and urine flow rate (UFR). Method: Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2009–2012 were used in our study. A total of 4172 participants and a total of nine PAH metabolites were examined. The UFR was measured as the amount of urine excreted in a period of time (mL/h). Several covariates were adjusted in linear regression models. Result: After adjusting for variables, the PAH metabolites in urine showed a significant correlation with UFR. Dose-dependent associations between PAH metabolites in the urine and UFR were also found. Higher quartiles of PAH metabolites in urine exhibited higher regression coefficients. Conclusion: Our study highlighted that PAH metabolites in urine had a strong association with decreased UFR in the US adult population. These findings support the possibility that PAH exposure is related to bladder dysfunction. Further prospective studies are warranted.

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Comparison of polycyclic aromatic hydrocarbon metabolite concentrations in urine of mothers and their newborns

Cited by 26 publications

References 29 publications

Possible Relationship between Respiratory Diseases and Urinary Concentrations of Polycyclic Aromatic Hydrocarbon Metabolites

Possible Relationship between Respiratory Diseases and Urinary Concentrations of Polycyclic Aromatic Hydrocarbon Metabolites

Exposure assessment of children living in homes with hookah smoking parents to polycyclic aromatic hydrocarbons: urinary level, exposure predictors, and risk assessment

Clinical Relevance of Urine Flow Rate and Exposure to Polycyclic Aromatic Hydrocarbons

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