1987
DOI: 10.1111/j.1600-0722.1987.tb01821.x
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Comparison of polyclonal and monoclonal antibodies to Actinomyces and Arachnia species

Abstract: Happonen R-P, Arstila P, Viander M, Soderling E, Viljanen M: Comparison of polyclonal and monoclonal antibodies to Actinomyces and Arachnia species, Scand J Dent Res 1987; 95: 136-43 Abstract -Polyclonal (PoAbs) and monoclonal (MoAbs) antibodies were produced to Actinomyces israelii serotypes 1 and 2, to Actinomyces naeslundii, and to Arachnia propionica, and their specificities were studied by an enzyme immunoassay (EIA), Ali PoAbs except those to A, propionica reacted also with at least one other Actinomy… Show more

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“…Such studies will be given much greater precision by the use of monoclonal antibodies which can be used as a primary coating in ELISA assays to "capture" only the specific antigen under test. Monoclonal antibodies now exist against a variety of antigens from bacteria incriminated in the aetiology of periodontal diseases such as F. nucleatum (Bird & Seymour 1987), B. gingivalis (Gmur & Guggenheim 1983, Chen et al 1986, Gmur et al 1988), B. forsythus and W. recta (Werner-Feldmayer et al 1988) and Aa (Place et al 1988) as well as those not currently incriminated such as Actinomyces and Arachnia species (Happonen et al 1987). Once the antigens are better characterised both in terms of their use as specific markers of the humoral antibody responses to distinguish between health and disease or between active or inactive disease and once their virulence properties (or lack of such) have also been estabHshed, then the way will be clear to investigate the role of antibodies in the modulation of virulence and thus the infectious mechanisms of the periodontal diseases.…”
Section: Discussionmentioning
confidence: 99%
“…Such studies will be given much greater precision by the use of monoclonal antibodies which can be used as a primary coating in ELISA assays to "capture" only the specific antigen under test. Monoclonal antibodies now exist against a variety of antigens from bacteria incriminated in the aetiology of periodontal diseases such as F. nucleatum (Bird & Seymour 1987), B. gingivalis (Gmur & Guggenheim 1983, Chen et al 1986, Gmur et al 1988), B. forsythus and W. recta (Werner-Feldmayer et al 1988) and Aa (Place et al 1988) as well as those not currently incriminated such as Actinomyces and Arachnia species (Happonen et al 1987). Once the antigens are better characterised both in terms of their use as specific markers of the humoral antibody responses to distinguish between health and disease or between active or inactive disease and once their virulence properties (or lack of such) have also been estabHshed, then the way will be clear to investigate the role of antibodies in the modulation of virulence and thus the infectious mechanisms of the periodontal diseases.…”
Section: Discussionmentioning
confidence: 99%