Comparison of Point-of-Care Versus  Central Laboratory Measurement of Electrolyte Concentrations on Calculations of the Anion Gap and the Strong Ion Difference

Morimatsu, Hiroshi; Rocktäschel, Jens; Bellomo, Rinaldo; Uchino, Shigehiko; Goldsmith, Donna; Gutteridge, Geoffrey A

doi:10.1097/00000542-200305000-00009

Cited by 97 publications

(91 citation statements)

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“…We are not the first to note differences in electrolyte concentration between ABG whole blood samples compared to venous plasma. Differences in sodium as well as chloride concentrations have been reported [5]. In this study, the observed difference could be traced back to consistently lower chloride concentrations in venous plasma samples compared to ABG and external quality control reference concentrations.…”

Section: To the Editorsupporting

confidence: 54%

“…For now, a practical solution to obtain a workable situation was chosen: a correction factor for chloride concentrations measured on the chemistry analysers has been implemented. However, this is neither desirable nor necessary, as others have reported similar problems > 10 years ago [5]. Standardisation of sodium has been largely accomplished, it is now time for diagnostic companies to standardise chloride measurements as well.…”

Section: To the Editormentioning

confidence: 99%

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Between analyser differences in chloride measurements and thus anion gap cause different interpretations of the acid-base balance

Geerts

Wlazlo

Scharnhorst³

2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Section: To the Editorsupporting

confidence: 54%

Section: To the Editormentioning

confidence: 99%

Between analyser differences in chloride measurements and thus anion gap cause different interpretations of the acid-base balance

Geerts

Wlazlo

Scharnhorst³

2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…The advantages and disadvantages of the various approaches to describing acid-base status (Table 2) have been the subject of several papers and reviews (64,77,78,79,158,160,212,217,232,255,290,293,336) Most of the criticism applied to the physicochemical approach is leveled at the errors inherent in the measurement of each independent variable, including those of each of the strong ions. Compared to other acid-base approaches, the physicochemical approach uses the largest number of measured variables because this approach intends to be as complete and accurate as possible.…”

Section: "Intricate Relationships Exist Between Arterial Blood Gasesmentioning

confidence: 99%

Effects of Gas Exchange on Acid‐Base Balance

Lindinger

Heigenhauser

2012

Comprehensive Physiology

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This paper describes the interactions between ventilation and acid-base balance under a variety of conditions including rest, exercise, altitude, pregnancy, and various muscle, respiratory, cardiac, and renal pathologies. We introduce the physicochemical approach to assessing acid-base status and demonstrate how this approach can be used to quantify the origins of acid-base disorders using examples from the literature. The relationships between chemoreceptor and metaboreceptor control of ventilation and acid-base balance summarized here for adults, youth, and in various pathological conditions. There is a dynamic interplay between disturbances in acid-base balance, that is, exercise, that affect ventilation as well as imposed or pathological disturbances of ventilation that affect acid-base balance. Interactions between ventilation and acid-base balance are highlighted for moderate- to high-intensity exercise, altitude, induced acidosis and alkalosis, pregnancy, obesity, and some pathological conditions. In many situations, complete acid-base data are lacking, indicating a need for further research aimed at elucidating mechanistic bases for relationships between alterations in acid-base state and the ventilatory responses.

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“…But, in the study of Mendel, prescription of Alfentanil caused to reduce bucking, coughing and hemodynamic effects after extubation without elongation of extubation time [22].…”

Section: Discussionmentioning

confidence: 96%

Comparison between the Effects of Alfentanil, Lidocaine and Their Composition in Controlling the Hemodynamic Responses at the Time of Awake Extubation of Patients

Alizadeh¹,

Aghaziarati²,

Zarin³

2017

IJCM

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Background and aim: Instability in the hemodynamic symptoms has been common at the time of extubation in patients and the cause to create the side effects. The aim of this research was to study the effect of injection of Alfentanil, Lidocaine and their composition in reduction of side effects arising from extubation. Materials and methods: 172 patients (20 -40 years old) that referred to Shahid Rajaee Hospital in 2014 and had been under the orthopedic surgery, were divided randomly and by using colored cards into four equal groups (43 patients in each group). Alfentanil (5 microgram/kilogram) was injected to the first group. The second group received Lidocaine (1 milligram/ kilogram). The composition of these two drugs was injected to the third group and the normal equal volume of Saline was injected to the fourth group which was the control group. The means of systolic and diastolic blood pressure, average arterial pressure and the number of heartbeat at the time of extubation were measured and registered 1, 5, 10, 15 and 20 minutes after extubation. Also, the amount of situation of bucking after extubation was registered in the groups. Results: The demographic results were similar in all groups. The mean of systolic blood pressure and number of heartbeats in the group of Alfentanil and composition of Alfentanil-Lidocaine had significant reduction (p < 0.05) in comparison with the control and Lidocaine group. The mean of diastolic blood pressure and average arterial pressure hadn't significant difference between the control group and other groups (p > 0.05). The situation of bucking in three treatment groups had significant reduction in comparison with control group. Conclusion: Alfentanil and composition of it with Lidocaine both had caused reducing the systolic blood pressure and heartbeats.

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Comparison of Point-of-Care Versus Central Laboratory Measurement of Electrolyte Concentrations on Calculations of the Anion Gap and the Strong Ion Difference

Abstract: Results with two different measurement technologies differed significantly for plasma sodium and chloride concentrations. These differences significantly affected the calculated AG and SID values and might lead clinicians to different assessments of acid-base and electrolyte status.

Cited by 97 publications

References 0 publications

Between analyser differences in chloride measurements and thus anion gap cause different interpretations of the acid-base balance

Between analyser differences in chloride measurements and thus anion gap cause different interpretations of the acid-base balance

Effects of Gas Exchange on Acid‐Base Balance

Comparison between the Effects of Alfentanil, Lidocaine and Their Composition in Controlling the Hemodynamic Responses at the Time of Awake Extubation of Patients

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