Comparison of Pleurodesis by Erythromycin, Talc, Doxycycline, and Diazepam in a Rabbit Model

Miller, Quintessa; Meschter, Carol; Neumaster, Terry; Pratt, J. M.; Moulton, Michael J.; Downey, Douglas M.; Harre, Joseph G.

doi:10.1016/j.cursur.2006.07.006

Cited by 25 publications

(12 citation statements)

References 12 publications

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“…Our study results conformed well to the previous result as clinical success occurred in 11 patients (73.3 3%) who received bleomycin, versus only 6 patients (40%) who took tetracycline. Moreover, treatment failure occurred more with the tetracycline group (9 patients, 60%); versus the bleomycin group (4 patients, 26.6%) [32,33] (see Fig. 1).…”

Section: Discussionmentioning

confidence: 91%

Malignant pleural effusion biomarkers as predictor for chemical pleurodesis success

Alsayed

Marzouk

Abelhalim

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: 42-77% of exudative pleural effusions are due to malignant diseases (Marel et al., 1993) [1]. This study aimed to evaluate the value of biochemical parameters of the pleural aspirate in predicting success of chemical pleurodesis in adult patients with malignant pleural effusion.Patients and methods: This prospective study included 30 adult patients with malignant pleural effusion diagnosed by clinical examination, Chest CT scanning and closed pleurocentesis. Patient ages were mean of 60.4 ± 7.8 years, multiple sessions of closed pleurocentesis were carried out followed by insertion of an intercostal tube. The pleural aspirate was then sent for chemical analysis to detect Glucose, pH, and LDH. Pleurodesis was then done either by using Tetracycline (group A), or Bleomycin (group B). All patients were then followed up for success of the pleurodesis process within one month.Results: Within one month of follow-up, rates of clinical response to treatment in group A (Tetracycline) were successful in 40%; versus group B (73.3%). Complete response (CR) occurred in group A cases (20%); versus 33.3% in group B; whereas partial response (PR) occurred in 3 cases of group A; versus 6 cases of group B; and treatment failure (TF) occurred in 9 of group A cases versus 4 of group B cases. None of our patients died. Morbidity occurred in the form of mild-to-moderate.The success of the pleurodesis was closely-associated with higher glucose and pH levels together with a low LDH level in the pleural fluid.Conclusion: The success of pleurodesis is usually higher when the pleural fluid pH and glucose levels are high & the LDH level is low in MPE.

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Section: Discussionmentioning

confidence: 91%

Malignant pleural effusion biomarkers as predictor for chemical pleurodesis success

Alsayed

Marzouk

Abelhalim

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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“…Pleural symphysis is the main objective of all the different treatments for recurrent pneumothorax; pleural abrasion or intrapleural instillation of sclerosing agents, such as tetracycline, silver nitrate, doxycycline, and talc. Of all the known sclerosing agents, talc is currently the one that presents the best results [5,[11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Treatment of primary spontaneous pneumothorax by videothoracoscopic talc pleurodesis under local anesthesia: a review of 133 procedures

Ramos-Izquierdo

Moya²,

Macía³

et al. 2009

Surg Endosc

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“…Various alternative sclerosing agents are used for the management of air leak when popular agent, such as talc, tetracycline are not available. [2][3][4][5] Our experience for the faster air leak cessation after TRD irrigation in patients with postoperative air leak and empyema lead us to use TRD as an alternative sclerosing agent for the management of air leak. TRD, a derivative of taurine, is a non-antibiotic antimicrobial agent with broad antibacterial and antifungal properties.…”

Section: Discussionmentioning

confidence: 99%

“…have been used for this procedure. [2][3][4][5] Availability of these agents is not universal. Talc is the most preferred and effective agent for pleurodesis in the many countries.…”

mentioning

confidence: 99%

Taurolidine: A New Alternative Agent for the Management of the Postoperative Air Leak

Byun

Park

Shim

et al. 2013

ATCS

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Purpose: To evaluate the efficacy of taurolidine instillation on postoperative air leak by clinical study and to investigate the mechanism of action by animal experiments. Methods: Outcomes of taurolidine instillation in patients with postoperative air leak were retrospectively reviewed. 100 ml of 1% taurolidine solution was instilled through a chest tube in patients with postoperative air leak lasting 4days or more. Success was defined as cessation of air leak within 24 hours with full expansion of lung on chest radiograph and subsequent removal of chest tube within another 24 hours. The effect of taurolidine instillation was estimated by development of adhesion and thickening of the visceral pleura in rabbits. The study group was compared with a control group and a talc poudrage group. Results: Out of 75 patients, the success rate was 66.7%. Out of 96 total attempts, taurolidine instillation was successful in 55%. In animal experiments, pleural adhesion was minimal in the taurolidine and control groups, whereas the talc group showed more adhesions. The taurolidine group showed a moderate visceral pleural thickening. The talc group showed severe visceral pleural thickening, whereas the control group showed mild thickening. Conclusion: Taurolidine is an effective alternative agent for the management of air leak. A chemical sclerosing effect is suggested as the mechanism of air leak cessation Keywords: taurolidine, instillation, air leak thus increases pain, risk of infection, and cost of care.

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Comparison of Pleurodesis by Erythromycin, Talc, Doxycycline, and Diazepam in a Rabbit Model

Cited by 25 publications

References 12 publications

Malignant pleural effusion biomarkers as predictor for chemical pleurodesis success

Malignant pleural effusion biomarkers as predictor for chemical pleurodesis success

Treatment of primary spontaneous pneumothorax by videothoracoscopic talc pleurodesis under local anesthesia: a review of 133 procedures

Taurolidine: A New Alternative Agent for the Management of the Postoperative Air Leak

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