Comparison of Platelet-Rich Plasma Collection Using the Haemonetics PCS and Baxter Autopheresis C

Abstract

We have compared 118 platelet-rich plasma donations collected using the Autopheresis-C Platelet cell™ (Auto C) with 166 donations using the Haemonetics PCS. The median platelet yield from the Auto C was superior (2.51 vs. 1.54 x 10^11) although collection times differed (60 vs./40min). There was greater variability in the platelet yield from the Auto C (0.45–5.6VS./0.26–2.8 x 10^11), but leucocyte contamination was not significantly different. After secondary processing, there was significantly less residual platelet-poor plasma (272 vs. 369 ml). Platelet function assessed during 5 days of storage was satisfactory for both, although platelet aggregation responses to collagen and adenosine diphosphate were superior in the Auto C platelets.

Bone and Wound Healing Augmentation with Platelet-Rich Plasma

“…11,155 For the platelets within the plasma fraction to become activated and degranulate, and thus release their growth factors, an exogenous application of 1000 IU of bovine thrombin per milliliter solution of 10% calcium chloride must be added. 12,136,143 After this, the clot that forms provides the vehicle that contains the growth factor milieu for delivery to the area of injury or site of therapy.…”