Comparison of platelet-lymphocyte ratio and CA 19-9 in differentiating benign from malignant head masses in patients with chronic pancreatitis

Kakkat, Shanavas; Rajan, Ramesh; Sindhu, R. S.; Natesh, Bonny; Raviram, S

doi:10.1007/s12664-017-0768-y

Cited by 6 publications

(8 citation statements)

References 12 publications

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“…Consistent with the results of the previous study, the present study demonstrated that LMR possessed important prognostic information for PDAC and was associated with poor OS. According to studies by Kakkat et al (27) and Asari et al (28), high pre-treatment PLR is an independent predictive risk factor for patients with PDAC, which was not demonstrated in the present study. In addition, the majority of the patients received chemotherapy, but the effect of chemotherapy on overall survival was not investigated; the effect of chemotherapy on the statistical importance of NLR and PLR in OS needs to be further explored in the future.…”

Section: Discussioncontrasting

confidence: 89%

Prognostic value of pre‑treatment peripheral blood markers in pancreatic ductal adenocarcinoma and their association with S100A4 expression in tumor tissue

Tian

et al. 2019

Oncol Lett

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The aims of the present study were to clarify the prognostic value of peripheral blood variables in patients with pancreatic ductal adenocarcinoma (PDAC), including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), and to determine the association between these variables and S100 calcium-binding protein A4 (S100A4) expression in tumor tissue, which is another prognostic factor for PDAC. Patients with PDAC were recruited at the Tianjin Medical University Cancer Institute and Hospital (Tianjin, China) between December 2008 and December 2014. A retrospective analysis was performed based on the recorded pre-treatment hematological parameters and clinical data. The prognostic value of NLR, PLR and LMR was examined. The association between these variables and S100A4 tissue expression was analyzed. Descriptive statistics and χ2 analyses were used in the present study. The median overall survival (OS) time of patients with PDAC was 9 months (range, 1–32 months). Univariate analysis revealed that NLR, LMR, carbohydrate antigen 19-9, surgery, chemotherapy, stage at diagnosis, tumor grade and age significantly affected OS. Although PLR exhibited no significant effects on OS, NLR and LMR were independent prognostic factors according to the multivariate analysis. Unpaired Student's t-test revealed differences between S100A4 expression and NLR, PLR and LMR. The results of the present study indicated that low NLR and high LMR were associated with a favorable prognosis in patients with PDAC. As a simply obtained and widely available index at diagnosis, NLR and LMR may become a novel predictive and classifying marker for PDAC in the clinical setting.

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Section: Discussioncontrasting

confidence: 89%

Prognostic value of pre‑treatment peripheral blood markers in pancreatic ductal adenocarcinoma and their association with S100A4 expression in tumor tissue

Tian

et al. 2019

Oncol Lett

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“…Persistence of the inflammatory process within the tumor leads to an increase in the proliferation of tumor cells, angiogenesis, and the inhibition of apoptosis [13,14]. Several reports have suggested that markers of systemic inflammation including cytokines, C-reactive protein, NLR, and PLR may provide useful information on the prognosis of colorectal gastrointestinal cancer [15,16]. Thus, pathogenesis of PAC appears to be an inflammation-driven malignancy, as well as colorectal gastrointestinal cancer.…”

Section: Inflammation and Pacmentioning

confidence: 99%

Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio, and Mean Platelet Volume for Detection of Resectable Pancreas Cancer

Sarıcı¹,

Düzgün²

2018

Biomarker - Indicator of Abnormal Physiological Process

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Several biomarkers have been preferred for the early diagnosis of pancreatic adenocancer (PAC), but most are not ready to be included as part of the routine diagnostic algorithm because they still lack sensitivity, specificity or reproducibility. CA19-9 is the most widely used serum-based marker for the diagnosis and follow-up of pancreatic cancer. However, CA19-9 lacks sensitivity for early or small-diameter pancreatic cancers. For more than 3 decades, information on neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV) has been widely available to health care practitioners, as part of the data provided in the full blood count. However, these biomarkers have more than used in the routine. The present chapter shares the prognostic significance of the hematological parameters in the light of our own findings and recent studies in the literature.

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“…An increasing number of studies have shown that elevated PLT levels are associated with tumor cell growth and angiogenesis ( 20 ). For example, it was reported that the PLT count in pancreatic ductal adenocarcinoma (PDAC) patients was higher than that in CP patients with an inflammatory mass of the pancreatic head ( 21 ). Similarly, the level of PLT in PC patients in an early tumor-node-metastasis (TNM) stage (I, II) was significantly higher than that in healthy controls ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring and validating the clinical risk factors for pancreatic cancer in chronic pancreatitis patients using electronic medical records datasets: three cohorts comprising 2,960 patients

Zhao¹,

Lang²,

Zhang³

et al. 2020

Transl Cancer Res TCR

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Background: Patients with chronic pancreatitis (CP) have an increased risk of developing pancreatic cancer (PC). The purpose of this study was to identify predictors of PC in CP patients.Methods: Electronic medical records (EMRs) of CP patients from two cohorts were collected, and a logistic regression analysis was performed to investigate the risk factors for PC. Subsequently, we validated the value of the risk prediction model with the EMRs of a third cohort. Results:The derivation cohort consisted of 2,545 CP patients, and among them, 14 patients developed PC 7 years after CP diagnosis. Cyst of the pancreas [COP; odds ratio (OR): 4.37, 95% confidence interval (CI):

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Comparison of platelet-lymphocyte ratio and CA 19-9 in differentiating benign from malignant head masses in patients with chronic pancreatitis

Abstract: PLR may be useful to differentiate PDAC from benign IHM in patients with chronic pancreatitis.

Cited by 6 publications

References 12 publications

Prognostic value of pre‑treatment peripheral blood markers in pancreatic ductal adenocarcinoma and their association with S100A4 expression in tumor tissue

Prognostic value of pre‑treatment peripheral blood markers in pancreatic ductal adenocarcinoma and their association with S100A4 expression in tumor tissue

Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio, and Mean Platelet Volume for Detection of Resectable Pancreas Cancer

Exploring and validating the clinical risk factors for pancreatic cancer in chronic pancreatitis patients using electronic medical records datasets: three cohorts comprising 2,960 patients

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