Comparison of plasma MicroRNA levels in drug naive, first episode depressed patients and healthy controls

Camkurt, Mehmet Akif; Acar, Şenel Tot; Coşkun, Salih; Güneş, Mehmet; Güneş, Serkan; Yılmaz, Mehmet; Görür, Ayşegül; Tamer, Lülüfer

doi:10.1016/j.jpsychires.2015.07.023

Cited by 86 publications

(55 citation statements)

References 32 publications

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“…The strengths of this study include the use of deep sequencing technology whereas other miRNA studies in depression have used a microarray approach . In general, there is very little overlap between the miRNAs identified in studies to date.…”

Section: Discussionmentioning

confidence: 99%

Peripheral blood microRNA and VEGFAmRNA changes following electroconvulsive therapy: implications for psychotic depression

Kolshus

Ryan

Blackshields

et al. 2017

Acta Psychiatr Scand

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Section: Discussionmentioning

confidence: 99%

Peripheral blood microRNA and VEGFAmRNA changes following electroconvulsive therapy: implications for psychotic depression

Kolshus

Ryan

Blackshields

et al. 2017

Acta Psychiatr Scand

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“…Similar to BD, these studies used PFC (BA9 or BA10) as the starting material. Additional studies have focused on changes of miRNA expression in peripheral blood or CSF (Belzeaux et al, 2012; Camkurt et al, 2015; Li et al, 2015; Li et al, 2013; Wan et al, 2015). Interestingly, targets of altered miRNAs in MDD play significant roles in several pathways associated with nervous system and brain functions, such as serotonin transporter ( SERT ) and metabotropic glutamate receptor 4 ( GRM4 ).…”

Section: Mirna Expression Studies In Neuropsychiatric Disordersmentioning

confidence: 99%

Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future

Alural

Genç

Haggarty

2017

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Neuropsychiatry disorders are common health problems affecting approximately 1% of the population. Twin, adoption, and family studies have displayed a strong genetic component for many of these disorders; however, the underlying pathophysiological mechanisms and neural substrates remain largely unknown. Given the critical need for new diagnostic markers and disease-modifying treatments, expanding the focus of genomic studies of neuropsychiatric disorders to include the role of non-coding RNAs (ncRNAs) is of growing interest. Of known types of ncRNAs, microRNAs (miRNAs) are 20–25-nucleotide, single-stranded, molecules that regulate gene expression through post-transcriptional mechanisms and have the potential to coordinately regulate complex regulatory networks. In this review, we summarize the current knowledge on miRNA alteration/dysregulation in neuropsychiatric disorders, with a special emphasis on schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). With an eye toward the future, we also discuss the diagnostic and prognostic potential of miRNAs for neuropsychiatric disorders in the context of personalized treatments and network medicine.

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“…miRs are highly enriched in the brain—50% of known mammalian miRs are expressed in the brain—and have been implicated in numerous neural processes including circuit formation and plasticity; synaptic function; and neuronal survival, differentiation, and diversity (O'Carroll and Schaefer, 2013). Dysregulated miRs have been reported in postmortem brain (Smalheiser et al, 2012; Issler et al, 2014; Lopez et al, 2014a,b; Maheu et al, 2015), blood (Belzeaux et al, 2012; Li et al, 2013; Fan et al, 2014; Issler et al, 2014; Lopez et al, 2014a; Camkurt et al, 2015), and dermal fibroblasts (Garbett et al, 2015) of depressed patients. In preclinical models, miRs have been implicated in depression-related processes ranging from glucocorticoid resistance (Uchida et al, 2008; Vreugdenhil et al, 2009) and corticotropin releasing factor sensitivity (Haramati et al, 2011), to behavioral resilience (Smalheiser et al, 2011; Dias et al, 2014; Issler et al, 2014) and antidepressant efficacy (Baudry et al, 2010; Issler et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens

Pfau

Purushothaman

Feng

et al. 2016

Front. Mol. Neurosci.

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Adult women are twice as likely as men to suffer from affective and anxiety disorders, although the mechanisms underlying heightened female stress susceptibility are incompletely understood. Recent findings in mouse Nucleus Accumbens (NAc) suggest a role for DNA methylation-driven sex differences in genome-wide transcriptional profiles. However, the role of another epigenetic process—microRNA (miR) regulation—has yet to be explored. We exposed male and female mice to Subchronic Variable Stress (SCVS), a stress paradigm that produces depression-like behavior in female, but not male, mice, and performed next generation mRNA and miR sequencing on NAc tissue. We applied a combination of differential expression, miR-mRNA network and functional enrichment analyses to characterize the transcriptional and post-transcriptional landscape of sex differences in NAc stress response. We find that male and female mice exhibit largely non-overlapping miR and mRNA profiles following SCVS. The two sexes also show enrichment of different molecular pathways and functions. Collectively, our results suggest that males and females mount fundamentally different transcriptional and post-transcriptional responses to SCVS and engage sex-specific molecular processes following stress. These findings have implications for the pathophysiology and treatment of stress-related disorders in women.

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Comparison of plasma MicroRNA levels in drug naive, first episode depressed patients and healthy controls

Cited by 86 publications

References 32 publications

Peripheral blood microRNA and VEGFAmRNA changes following electroconvulsive therapy: implications for psychotic depression

Peripheral blood microRNA and VEGFAmRNA changes following electroconvulsive therapy: implications for psychotic depression

Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future

Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens

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