Comparison of Plasma Concentrations of Levobupivacaine With and Without Epinephrine for Transversus Abdominis Plane Block

Abstract

Adding epinephrine to levobupivacaine reduces its peak plasma concentration after unilateral TAP blocks, with no remarkable effects on block characteristics or duration.

Efficacy of transverse abdominis plane block in reduction of postoperation pain in laparoscopic cholecystectomy

“…It has been shown that adding epinephrine to levobupivacaine reduces its peak plasma concentration after unilateral TAP blocks, with no remarkable effects on block characteristics or duration. 19 However, adding clonidine to a TAP block using bupivacaine did not affect wound hyperalgesia index or improve short-or long-term pain scores in women undergoing elective cesarean delivery. 20 The addition of fentanyl to local anesthetics improved the quality and prolonged the duration of cervical plexus block.…”

Ultrasound-Guided Transverses Abdominis Plane Block versus Caudal Block for Postoperative Analgesia in Children Undergoing Inguinal Hernia Repair: A Randomized Controlled Trial

“…Although the analgesic efficacy of UTAP has been proven, the duration of analgesia remains uncertain (16,17). An important reason for the variability in analgesia efficacy is the unique anatomical characteristics.…”

Local anesthetic systemic toxicity: Continuing Professional Development

“…38 Bien qu'une tendance récente vise à éviter cet agent dans les blocs nerveux périphériques en raison d'une crainte que la vasoconstriction locale exacerbe sa neurotoxicité, les données probantes cliniques font encore défaut. Enfin, l'épinéphrine a l'avantage supplémentaire de réduire les concentrations plasmatiques maximales d'AL, 39 ce qui, tout bien considéré, rend les avantages de l'épinéphrine bien plus importants que ses limites et risques potentiels. …”

“…38 While there has been a recent trend to avoid epinephrine in peripheral nerve blockade because of concerns that local vasoconstriction may exacerbate neurotoxicity, this has yet to be clinically proven. Finally, epinephrine has the additional advantage of reducing peak LA plasma concentration, 39 and thus, on balance, the advantages of epinephrine far outweigh its limitations and potential risks.…”